Parameters of Glucose and Lipid Metabolism Affect the Occurrence of Colorectal Adenomas Detected by Surveillance Colonoscopies
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Purpose: Limited data are available regarding the associations between parameters of glucose and lipid metabolism and the occurrenceof metachronous adenomas. We investigated whether these parameters affect the occurrence of adenomas detected on surveillance colonoscopy. Materials and Methods: This longitudinal study was performed on 5289 subjects who underwent follow-up colonoscopy between 2012 and 2013 among 62171 asymptomatic subjects who underwent an initial colonoscopy for a health check-up between 2010 and 2011. The risk of adenoma occurrence was assessed using Cox proportional hazards modeling. Results: The mean interval between the initial and follow-up colonoscopy was 2.2±0.6 years. The occurrence of adenomas detected by the follow-up colonoscopy increased linearly with the increasing quartiles of fasting glucose, hemoglobin A1c (HbA1c), insulin, homeostasis model assessment of insulin resistance (HOMA-IR), and triglycerides measured at the initial colonoscopy. These associationspersisted after adjusting for confounding factors. The adjusted hazard ratios for adenoma occurrence comparing the fourth with the first quartiles of fasting glucose, HbA1c, insulin, HOMA-IR, and triglycerides were 1.50 [95% confidence interval (CI), 1.26–1.77; ptrend<0.001], 1.22 (95% CI, 1.04–1.43; ptrend=0.024), 1.22 (95% CI, 1.02–1.46; ptrend=0.046), 1.36 (95% CI, 1.14–1.63; ptrend=0.004), and 1.19 (95% CI, 0.99–1.42; ptrend=0.041), respectively. In addition, increasing quartiles of low-density lipoprotein-cholesterol and apolipoproteinB were associated with an increasing occurrence of adenomas. Conclusion: The levels of parameters of glucose and lipid metabolism were significantly associated with the occurrence of adenomasdetected on surveillance colonoscopy. Improving the parameters of glucose and lipid metabolism through lifestyle changes or medications may be helpful in preventing metachronous adenomas.
Abstract
Purpose: Limited data are available regarding the associations between parameters of glucose and lipid metabolism and the occurrenceof metachronous adenomas. We investigated whether these parameters affect the occurrence of adenomas detected on surveillance colonoscopy. Materials and Methods: This longitudinal study was performed on 5289 subjects who underwent follow-up colonoscopy between 2012 and 2013 among 62171 asymptomatic subjects who underwent an initial colonoscopy for a health check-up between 2010 and 2011. The risk of adenoma occurrence was assessed using Cox proportional hazards modeling. Results: The mean interval between the initial and follow-up colonoscopy was 2.2±0.6 years. The occurrence of adenomas detected by the follow-up colonoscopy increased linearly with the increasing quartiles of fasting glucose, hemoglobin A1c (HbA1c), insulin, homeostasis model assessment of insulin resistance (HOMA-IR), and triglycerides measured at the initial colonoscopy. These associationspersisted after adjusting for confounding factors. The adjusted hazard ratios for adenoma occurrence comparing the fourth with the first quartiles of fasting glucose, HbA1c, insulin, HOMA-IR, and triglycerides were 1.50 [95% confidence interval (CI), 1.26–1.77; ptrend<0.001], 1.22 (95% CI, 1.04–1.43; ptrend=0.024), 1.22 (95% CI, 1.02–1.46; ptrend=0.046), 1.36 (95% CI, 1.14–1.63; ptrend=0.004), and 1.19 (95% CI, 0.99–1.42; ptrend=0.041), respectively. In addition, increasing quartiles of low-density lipoprotein-cholesterol and apolipoproteinB were associated with an increasing occurrence of adenomas. Conclusion: The levels of parameters of glucose and lipid metabolism were significantly associated with the occurrence of adenomasdetected on surveillance colonoscopy. Improving the parameters of glucose and lipid metabolism through lifestyle changes or medications may be helpful in preventing metachronous adenomas.
참고문헌 (41)
- 이현석, "Is Retroflexion Helpful in Detecting Adenomas in the Right Colon?: A Single Center Interim Analysis", Intestinal research, 13(4), pp.326~331 (2015), 대한장연구학회
- Otto S. Lin, "Impact of Sigmoidoscopy and Colonoscopy on Colorectal Cancer Incidence and Mortality: An Evidence-Based Review of Published Prospective and Retrospective Studies", Intestinal research, 12(4), pp.268~274 (2014), 대한장연구학회
- Lieberman DA, "Guidelines for colonoscopy surveillance after screening and polypectomy: a consensus update by the US Multi-Society Task Force on Colorectal Cancer", Gastroenterology, 143, pp.844~857 (2012)
- Luo S, "Diabetes mellitus increases the risk of colorectal neoplasia: an updated metaanalysis", Clin Res Hepatol Gastroenterol, 40, pp.110~123 (2016)
- Kim BC, "Association of colorectal adenoma with components of metabolic syndrome", Cancer Causes Control, 23, pp.727~735 (2012)
- Liu CS, "Central obesity and atherogenic dyslipidemia in metabolic syndrome are associated with increased risk for colorectal adenoma in a Chinese population", BMC Gastroenterol, 10, pp.51~ (2010)
- 최윤희, "Troglitazone Enhances the Apoptotic Response of DLD-1 Colon Cancer Cells to Photodynamic Therapy", Yonsei Medical Journal, 57(6), pp.1494~1499 (2016), 연세대학교의과대학[DOI]
- Keku TO, "Insulin resistance, apoptosis, and colorectal adenoma risk", Cancer Epidemiol Biomarkers Prev, 14, pp.2076~2081 (2005)
- Rampal S, "Association between markers of glucose metabolism and risk of colorectal adenoma", Gastroenterology, 147, pp.78~87 (2014)
- Vidal AC, "Elevated C-peptide and insulin predict increased risk of colorectal adenomas in normal mucosa", BMC Cancer, 12, pp.389~ (2012)
- Ortiz AP, "Insulin resistance, central obesity, and risk of colorectal adenomas", Cancer, 118, pp.1774~1781 (2012)
- Misciagna G, "Serum fructosamine and colorectal adenomas", Eur J Epidemiol, 19, pp.425~432 (2004)
- Yamada K, "Relation of serum total cholesterol, serum triglycerides and fasting plasma glucose to colorectal carcinoma in situ", Int J Epidemiol, 27, pp.794~798 (1998)
- Yang MH, "The association of serum lipids with colorectal adenomas", Am J Gastroenterol, 108, pp.833~841 (2013)
- Bayerdörffer E, "Decreased high-density lipoprotein cholesterol and increased low-density cholesterol levels in patients with colorectal adenomas", Ann Intern Med, 118, pp.481~487 (1993)
- van Duijnhoven FJ, "Blood lipid and lipoprotein concentrations and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition", Gut, 60, pp.1094~1102 (2011)
- Jung YS, "Associations between parameters of glucose and lipid metabolism and risk of colorectal neoplasm", Dig Dis Sci, 60, pp.2996~3004 (2015)
- Taniguchi L, "Metabolic factors accelerate colorectal adenoma recurrence", BMC Gastroenterol, 14, pp.187~ (2014)
- Jacobs ET, "Association between body size and colorectal adenoma recurrence", Clin Gastroenterol Hepatol, 5, pp.982~990 (2007)
- Laiyemo AO, "Obesity, weight change, and risk of adenoma recurrence:a prospective trial", Endoscopy, 44, pp.813~818 (2012)
- So H, "Metabolic factors affect the occurrence of colorectal neoplasm on surveillance colonoscopies", J Gastroenterol Hepatol, 31, pp.1273~1279 (2016)
- Chiu HM, "Effects of metabolic syndrome and findings from baseline colonoscopies on occurrence of colorectal neoplasms", Clin Gastroenterol Hepatol, 13, pp.1134~1142 (2015)
- Lin CC, "Hypertension is an important predictor of recurrent colorectal adenoma after screening colonoscopy with adenoma polypectomy", J Chin Med Assoc, 77, pp.508~512 (2014)
- Kim MC, "Metabolic syndrome is associated with increased risk of recurrent colorectal adenomas in Korean men", Int J Obes (Lond), 36, pp.1007~1011 (2012)
- Hye-Won Park, "Colorectal Neoplasm in Asymptomatic Average-risk Koreans: The KASID Prospective Multicenter Colonoscopy Survey", Gut and Liver, 3(1), pp.35~40 (2009), 거트앤리버 발행위원회
- Kitahara CM, "Prospective investigation of body mass index, colorectal adenoma, and colorectal cancer in the prostate, lung, colorectal, and ovarian cancer screening trial", J Clin Oncol, 31, pp.2450~2459 (2013)
- Ng SC, "Colorectal cancer screening in Asia", Br Med Bull, 105, pp.29~42 (2013)
- Hsu YC, "Glycated hemoglobin A1c is superior to fasting plasma glucose as an independent risk factor for colorectal neoplasia", Cancer Causes Control, 23, pp.321~328 (2012)
- Kim BJ, "Clinical usefulness of glycosylated hemoglobin as a predictor of adenomatous polyps in the colorectum of middle-aged males", Cancer Causes Control, 21, pp.939~944 (2010)
- Sasaki Y, "Serum Interleukin-6, insulin, and HOMA-IR in male individuals with colorectal adenoma", Clin Cancer Res, 18, pp.392~399 (2012)
- Otani T, "Serum triglycerides and colorectal adenoma in a case-control study among cancer screening examinees (Japan)", Cancer Causes Control, 17, pp.1245~1252 (2006)
- Sun ZJ, "The association of serum lipids with the histological pattern of rectosigmoid adenoma in Taiwanese adults", BMC Gastroenterol, 11, pp.54~ (2011)
- Shikata K, "Diabetes mellitus and cancer risk: review of the epidemiological evidence", Cancer Sci, 104, pp.9~14 (2013)
- Esteve E, "Dyslipidemia and inflammation:an evolutionary conserved mechanism", Clin Nutr, 24, pp.16~31 (2005)
- Cowey S, "The metabolic syndrome: a high-risk state for cancer?", Am J Pathol, 169, pp.1505~1522 (2006)
- Franciosi M, "Metformin therapy and risk of cancer in patients with type 2 diabetes: systematic review", PLoS One, 8, pp.e71583~ (2013)
- Liu Y, "Association between statin use and colorectal cancer risk: a meta-analysis of 42 studies", Cancer Causes Control, 25, pp.237~249 (2014)
- 김요한, "Inhibitory Effect of Metformin Therapy on the Incidence of Colorectal Advanced Adenomas in Patients With Diabetes", Intestinal research, 13(2), pp.145~152 (2015), 대한장연구학회
- Youn Hee Cho, "Does Metformin Affect The Incidence of Colonic Polyps and Adenomas in Patients with Type 2 Diabetes Mellitus?", Intestinal research, 12(2), pp.139~145 (2014), 대한장연구학회
- Broughton T, "Statin use is associated with a reduced incidence of colorectal adenomatous polyps", Int J Colorectal Dis, 28, pp.469~476 (2013)
- Marks AR, "Metformin use and risk of colorectal adenoma after polypectomy in patients with type 2 diabetes mellitus", Cancer Epidemiol Biomarkers Prev, 24, pp.1692~1698 (2015)