Stem Cell Therapy for Neonatal Disorders: Prospects and Challenges
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Despite recent advances in neonatal medicine, neonatal disorders, such as bronchopulmonary dysplasia and intraventricular hemorrhagein preterm neonates and hypoxic ischemic encephalopathy in term neonates, remain major causes of mortality and morbidities. Promising preclinical research results suggest that stem cell therapies represent the next breakthrough in the treatment of currently intractable and devastating neonatal disorders with complex multifactorial etiologies. This review focuses primarily on the potential role of stem cell therapy in the above mentioned neonatal disorders, highlighting the results of human clinical trials and the challenges that remain to be addressed for their safe and successful translation into clinical care of newborn infants.
Abstract
Despite recent advances in neonatal medicine, neonatal disorders, such as bronchopulmonary dysplasia and intraventricular hemorrhagein preterm neonates and hypoxic ischemic encephalopathy in term neonates, remain major causes of mortality and morbidities. Promising preclinical research results suggest that stem cell therapies represent the next breakthrough in the treatment of currently intractable and devastating neonatal disorders with complex multifactorial etiologies. This review focuses primarily on the potential role of stem cell therapy in the above mentioned neonatal disorders, highlighting the results of human clinical trials and the challenges that remain to be addressed for their safe and successful translation into clinical care of newborn infants.
참고문헌 (55)
- Bland RD, "Neonatal chronic lung disease in the post-surfactant era", Biol Neonate, 88, pp.181~191 (2005)
- Bhandari A, "Pulmonary outcomes in bronchopulmonary dysplasia", Semin Perinatol, 30, pp.219~226 (2006)
- Vohr BR, "Neurodevelopmental and functional outcomes of extremely low birth weight infants in the national institute of child health and human development neonatal research network, 1993-1994", Pediatrics, 105, pp.1216~1226 (2000)
- Johnston MV, "Hypoxic and ischemic disorders of infants and children. Lecture for 38th meeting of Japanese Society of Child Neurology, Tokyo, Japan, July 1996", Brain Dev, 19, pp.235~239 (1997)
- Chang YS, "Human umbilical cord blood-derived mesenchymal stem cells attenuate hyperoxia-induced lung injury in neonatal rats", Cell Transplant, 18, pp.869~886 (2009)
- Park WS, "Hypothermia augments neuroprotective activity of mesenchymal stem cells for neonatal hypoxic-ischemic encephalopathy", PLoS One, 10, pp.e0120893~ (2015)
- Ahn SY, "Mesenchymal stem cells prevent hydrocephalus after severe intraventricular hemorrhage", Stroke, 44, pp.497~504 (2013)
- Chang YS, "Mesenchymal stem cells for bronchopulmonary dysplasia: phase 1dose-escalation clinical trial", J Pediatr, 164, pp.966~972 (2014)
- Cotten CM, "Feasibility of autologous cord blood cells for infants with hypoxic-ischemic encephalopathy", J Pediatr, 164, pp.973~979 (2014)
- 안소윤, "Long-Term (Postnatal Day 70) Outcome and Safety of Intratracheal Transplantation of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Neonatal Hyperoxic Lung Injury", Yonsei Medical Journal, 54(2), pp.416~424 (2013), 연세대학교의과대학[DOI]
- Pierro M, "Short-term, long-term and paracrine effect of human umbilical cord-derived stem cells in lung injury prevention and repair in experimental bronchopulmonary dysplasia", Thorax, 68, pp.475~484 (2013)
- Chang YS, "Timing of umbilical cord blood derived mesenchymal stem cells transplantation determines therapeutic efficacy in the neonatal hyperoxic lung injury", PLoS One, 8, pp.e52419~ (2013)
- Chang YS, "Intratracheal transplantation of human umbilical cord blood-derived mesenchymal stem cells dose-dependently attenuates hyperoxia-induced lung injury in neonatal rats", Cell Transplant, 20, pp.1843~1854 (2011)
- 안소윤, "Stem Cell Therapy for Bronchopulmonary Dysplasia: Bench to Bedside Translation", Journal of Korean Medical Science, 30(5), pp.509~513 (2015), 대한의학회
- Ahn SY, "Cell type-dependent variation in paracrine potency determines therapeutic efficacy against neonatal hyperoxic lung injury", Cytotherapy, 17, pp.1025~1035 (2015)
- So Yoon Ahn, "Pivotal Role of Brain-Derived Neurotrophic Factor Secreted by Mesenchymal Stem Cells in Severe Intraventricular Hemorrhage in Newborn Rats", Cell Transplantation, 26(1), pp.145~156 (2017), SAGE Publications[DOI]
- Ahn SY, "Optimal route for mesenchymal stem cells transplantation after severe intraventricular hemorrhage in newborn rats", PLoS One, 10, pp.e0132919~ (2015)
- Spencer ND, "Mesenchymal stromal cells:past, present, and future", Vet Surg, 40, pp.129~139 (2011)
- Parad RB, "Prediction of respiratory outcome in extremely low gestational age infants", Neonatology, 107, pp.241~248 (2015)
- Parsons PE, "Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury", Crit Care Med, 33, pp.1~6 (2005)
- Noël D, "Multipotent mesenchymal stromal cells and immune tolerance", Leuk Lymphoma, 48, pp.1283~1289 (2007)
- Waszak P, "Preconditioning enhances the paracrine effect of mesenchymal stem cells in preventing oxygen-induced neonatal lung injury in rats", Stem Cells Dev, 21, pp.2789~2797 (2012)
- Rocha V, "Graft-versus-host disease in children who have received a cord-blood or bone marrow transplant from an HLA-identical sibling. Eurocord and international bone marrow transplant registry working committee on alternative donor and stem cell sources", N Engl J Med, 342, pp.1846~1854 (2000)
- Le Blanc K, "Immunomodulatory effects of fetal and adult mesenchymal stem cells", Cytotherapy, 5, pp.485~489 (2003)
- Kern S, "Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue", Stem Cells, 24, pp.1294~1301 (2006)
- Yang SE, "Mesenchymal stem", progenitor cells developed in cultures from UC blood, 2004, pp.6, 476~486
- Amable PR, "Protein synthesis and secretion in human mesenchymal cells derived from bone marrow, adipose tissue and Wharton’s jelly", Stem Cell Res Ther, 5, pp.53~ (2014)
- Mendicino M, "MSCbased product characterization for clinical trials: an FDA perspective", Cell Stem Cell, 14, pp.141~145 (2014)
- Laughon MM, "Prediction of bronchopulmonary dysplasia by postnatal age in extremely premature infants", Am J Respir Crit Care Med, 183, pp.1715~1722 (2011)
- D’Angio CT, "Blood cytokine profiles associated with distinct patterns of bronchopulmonary dysplasia among extremely low birth weight infants", J Pediatr, 174, pp.45~51 (2016)
- Azzopardi DV, "Moderate hypothermia to treat perinatal asphyxial encephalopathy", N Engl J Med, 361, pp.1349~1358 (2009)
- Shankaran S, "Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy", N Engl J Med, 353, pp.1574~1584 (2005)
- Chalak LF, "Biomarkers for severity of neonatal hypoxic-ischemic encephalopathy and outcomes in newborns receiving hypothermia therapy", J Pediatr, 164, pp.468~474 (2014)
- Murphy BP, "Posthaemorrhagic ventricular dilatation in the premature infant: natural history and predictors of outcome", Arch Dis Child Fetal Neonatal Ed, 87, pp.F37~F41 (2002)
- Merhar S, "Biomarkers in neonatal posthemorrhagic hydrocephalus", Neonatology, 101, pp.1~7 (2012)
- Spaggiari GM, "Mesenchymal stem cell-natural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation", Blood, 107, pp.1484~1490 (2006)
- Fang B, "Intrathecal transplantation of bone marrow stromal cells attenuates blood-spinal cord barrier disruption induced by spinal cord ischemia-reperfusion injury in rabbits", J Vasc Surg, 58, pp.1043~1052 (2013)
- Donega V, "Assessment of long-term safety and efficacy of intranasal mesenchymal stem cell treatment for neonatal brain injury in the mouse", Pediatr Res, 78, pp.520~526 (2015)
- Sung DK, "Optimal route for human umbilical cord blood-derived mesenchymal stem cell transplantation to protect against neonatal hyperoxic lung injury: gene expression profiles and histopathology", PLoS One, 10, pp.e0135574~ (2015)
- Liu L, "Intranasal versus intraperitoneal delivery of human umbilical cord tissuederived cultured mesenchymal stromal cells in a murine model of neonatal lung injury", Am J Pathol, 184, pp.3344~3358 (2014)
- Grade S, "Brain-derived neurotrophic factor promotes vasculature-associated migration of neuronal precursors toward the ischemic striatum", PLoS One, 8, pp.e55039~ (2013)
- Hudgins RJ, "Intrathecal urokinase as a treatment for intraventricular hemorrhage in the preterm infant", Pediatr Neurosurg, 26, pp.281~287 (1997)
- Rojas M, "Bone marrow-derived mesenchymal stem cells in repair of the injured lung", Am J Respir Cell Mol Biol, 33, pp.145~152 (2005)
- Ortiz LA, "Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects", Proc Natl Acad Sci U S A, 100, pp.8407~8411 (2003)
- Aslam M, "Bone marrow stromal cells attenuate lung injury in a murine model of neonatal chronic lung disease", Am J Respir Crit Care Med, 180, pp.1122~1130 (2009)
- Ahn SY, "Stem cell for neonatal brain disorders", Neonatology, 109, pp.377~383 (2016)
- van Haaften T, "Airway delivery of mesenchymal stem cells prevents arrested alveolar growth in neonatal lung injury in rats", Am J Respir Crit Care Med, 180, pp.1131~1142 (2009)
- Comi AM, "Neural stem cells reduce brain injury after unilateral carotid ligation", Pediatr Neurol, 38, pp.86~92 (2008)
- Donega V, "Intranasal mesenchymal stem cell treatment for neonatal brain damage: long-term cognitive and sensorimotor improvement", PLoS One, 8, pp.e51253~ (2013)
- Mosna F, "Human bone marrow and adipose tissue mesenchymal stem cells: a user’s guide", Stem Cells Dev, 19, pp.1449~1470 (2010)
- Yasuhara T, "Mannitol facilitates neurotrophic factor up-regulation and behavioural recovery in neonatal hypoxic-ischaemic rats with human umbilical cord blood grafts", J Cell Mol Med, 14, pp.914~921 (2010)
- Park WS, "Optimal timing of mesenchymal stem cell therapy for neonatal intraventricular hemorrhage", Cell Transplant, 25, pp.1131~1144 (2016)
- Yañez R, "Adipose tissue-derived mesenchymal stem cells have in vivo immunosuppressive properties applicable for the control of the graft-versus-host disease", Stem Cells, 24, pp.2582~2591 (2006)
- Walter LM, "Augmented cardiovascular responses to episodes of repetitive compared with isolated respiratory events in preschool children with sleep-disordered breathing", Pediatr Res, 78, pp.560~566 (2015)
- Ankrum JA, "Mesenchymal stem cells: immune evasive, not immune privileged", Nat Biotechnol, 32, pp.252~260 (2014)
