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Stem Cell Therapy for Neonatal Disorders: Prospects and Challenges

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초록

Despite recent advances in neonatal medicine, neonatal disorders, such as bronchopulmonary dysplasia and intraventricular hemorrhagein preterm neonates and hypoxic ischemic encephalopathy in term neonates, remain major causes of mortality and morbidities. Promising preclinical research results suggest that stem cell therapies represent the next breakthrough in the treatment of currently intractable and devastating neonatal disorders with complex multifactorial etiologies. This review focuses primarily on the potential role of stem cell therapy in the above mentioned neonatal disorders, highlighting the results of human clinical trials and the challenges that remain to be addressed for their safe and successful translation into clinical care of newborn infants.

Abstract

Despite recent advances in neonatal medicine, neonatal disorders, such as bronchopulmonary dysplasia and intraventricular hemorrhagein preterm neonates and hypoxic ischemic encephalopathy in term neonates, remain major causes of mortality and morbidities. Promising preclinical research results suggest that stem cell therapies represent the next breakthrough in the treatment of currently intractable and devastating neonatal disorders with complex multifactorial etiologies. This review focuses primarily on the potential role of stem cell therapy in the above mentioned neonatal disorders, highlighting the results of human clinical trials and the challenges that remain to be addressed for their safe and successful translation into clinical care of newborn infants.

참고문헌 (55)

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관련 논문AI추천

Long-Term (Postnatal Day 70) Outcome and Safety of Intratracheal Transplantation of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Neonatal Hyperoxic Lung Injury김수윤, 김은선, 박원순, 성동경, 안소윤, 오원일, 유욱준, 장윤실, 최수진, So Yub Rime연세대학교의과대학 · Yonsei Medical Journal2013 · 제54권 제2호Human Umbilical Cord Blood CD34-Positive Cells as Predictors of the Incidence and Short-Term Outcome of Neonatal Hypoxic-Ischemic Encephalopathy: A Pilot StudyAbir Ibrahim, Adel E. Abdelhamid, Hanaa A. Amer, Mohamed Hassan Nasr Eldin, Moustafa El-Houssinie, Sahar M.A. Hassanein대한신경과학회 · Journal of Clinical Neurology2017 · 제13권 제1호신생아 저산소성 허혈성 뇌손상에서 신경줄기세포의 치료적 적용이철, 구교연, 김미리, 김일선, 김정은, 남궁란, 박국인, 신정은, 유하양, 윤석환, 은호선, 이일신, 정광수대한신생아학회 · Neonatal medicine2013 · 제20권 제3호Human Neural Stem Cells: Translational Research for Neonatal Hypoxic-Ischemic Brain Injury박국인, 신정은, 은호선, Joo Hee Lim, Jungho Han대한신생아학회 · Neonatal medicine2019 · 제26권 제1호Recent Achievements in Stem Cell Therapy for Pediatric Gastrointestinal Tract Disease배선환대한소아소화기영양학회 · Pediatric Gastroenterology, Hepatology & Nutrition2013 · 제16권 제1호Optimizing Stem Cell Therapy after Ischemic Brain InjuryBilal Moiz, Brittany Bolduc Lachance, Shuai Zhang, Xiaofeng Jia대한뇌졸중학회 · 대한뇌졸중영문학회지2020 · 제22권 제3호

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