Serological Biomarkers and Indices for the Current Activity and Prognosis of ANCA-Associated Vasculitis: Experience in a Single Centre in Korea
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초록
Small vessel vasculitis is composed of two types of vasculitis based on immune-complex deposits, immune-complex vasculitis and antineutrophil cytoplasmic antibody-associated vasculitis (AAV) according to the 2012 Chapel Hill Consensus Conferences Nomenclature of Vasculitis. In general, the current disease-states are assessed in three ways in real clinical practice such as activity, damage and functional status. Birmingham vasculitis activity score (BVAS, version 3) and five-factor score were calculated for assessing the cross-sectional activity and for predicting the prognosis of AAV, respectively. Since BVAS includes a wide spectrum of nine systemic items with differently weighted scores based on new-onset/worsening or persistent each symptom, it has been considered as the most reliable tool to assess AAV activity to date. However, since BVAS represents both cross-sectional and chronic clinical features, it has a limitation in flexibly reflecting the cross-sectional activity or severity of AAV. In addition, the heterogeneous items of BVAS are difficult to reflect the close correlation between BVAS and AAV pathogenesis. It is practically difficult to discover new biomarkers or indices that exceed the reliability of AAV-specific indices or acute-phase reactants established by long clinical experience. However, efforts to discover and develop new biomarkers or indices are expected to complement the clinical unmet need of existing AAV-specific indices and acute-phase reactants. In this review, we reviewed the serological biomarkers and indices that have been reported to date and introduced studies that investigated serological biomarkers and indices in Korean patients with AAV.
Abstract
Small vessel vasculitis is composed of two types of vasculitis based on immune-complex deposits, immune-complex vasculitis and antineutrophil cytoplasmic antibody-associated vasculitis (AAV) according to the 2012 Chapel Hill Consensus Conferences Nomenclature of Vasculitis. In general, the current disease-states are assessed in three ways in real clinical practice such as activity, damage and functional status. Birmingham vasculitis activity score (BVAS, version 3) and five-factor score were calculated for assessing the cross-sectional activity and for predicting the prognosis of AAV, respectively. Since BVAS includes a wide spectrum of nine systemic items with differently weighted scores based on new-onset/worsening or persistent each symptom, it has been considered as the most reliable tool to assess AAV activity to date. However, since BVAS represents both cross-sectional and chronic clinical features, it has a limitation in flexibly reflecting the cross-sectional activity or severity of AAV. In addition, the heterogeneous items of BVAS are difficult to reflect the close correlation between BVAS and AAV pathogenesis. It is practically difficult to discover new biomarkers or indices that exceed the reliability of AAV-specific indices or acute-phase reactants established by long clinical experience. However, efforts to discover and develop new biomarkers or indices are expected to complement the clinical unmet need of existing AAV-specific indices and acute-phase reactants. In this review, we reviewed the serological biomarkers and indices that have been reported to date and introduced studies that investigated serological biomarkers and indices in Korean patients with AAV.
참고문헌 (76)
- Jennette JC, "2012 revised international chapel hill consensus conference nomenclature of vasculitides", Arthritis Rheum, 65, pp.1~11 (2013)
- Watts R, "Development and validation of a consensus methodology for the classification of the ANCA-associated vasculitides and polyarteritis nodosa for epidemiological studies", Ann Rheum Dis, 66, pp.222~227 (2007)
- Mukhtyar C, "Modification and validation of the Birmingham Vasculitis Activity Score(version 3)", Ann Rheum Dis, 68, pp.1827~1832 (2009)
- Guillevin L, "The Five-Factor Score revisited: assessment of prognoses of systemic necrotizing vasculitides based on the French Vasculitis Study Group (FVSG) cohort", Medicine(Baltimore), 90, pp.19~27 (2011)
- Bhamra K, "Damage assessment in ANCA-associated vasculitis", Curr Rheumatol Rep, 14, pp.494~500 (2012)
- Han CW, "Development of the Korean version of Short-Form 36-Item Health Survey : health related QOL of healthy elderly people and elderly patients in Korea", Tohoku J Exp Med, 203, pp.189~194 (2004)
- Jennette JC, "Pathogenesis of antineutrophil cytoplasmic autoantibody-mediated disease", Nat Rev Rheumatol, 10, pp.463~473 (2014)
- 최찬범, "Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in Korea: A Narrative Review", Yonsei Medical Journal, 60(1), pp.10~21 (2019), 연세대학교의과대학[DOI]
- Lamprecht P, "Pathogenetic and clinical aspects of anti-neutrophil cytoplasmic autoantibody-associated vasculitides", Front Immunol, 9, pp.680~ (2018)
- Strimbu K, "What are biomarkers?", Curr Opin HIV AIDS, 5, pp.463~466 (2010)
- Nimse SB, "Biomarker detection technologies and future directions", Analyst, 141, pp.740~755 (2016)
- Fall DJ, "Utilization of translational bioinformatics to identify novel biomarkers of bortezomib resistance in multiple myeloma", J Cancer, 5, pp.720~727 (2014)
- Koh JH, "Editorial: can an Increase in antineutrophil cytoplasmic autoantibody titer predict relapses in antineutrophil cytoplasmic antibody-associated vasculitis?", Arthritis Rheumatol, 68, pp.1571~1573 (2016)
- Lally L, "Biomarkers in ANCA-associated vasculitis", Curr Rheumatol Rep, 15, pp.363~ (2013)
- Kain R, "High prevalence of autoantibodies to hLAMP-2 in anti-neutrophil cytoplasmic antibody-associated vasculitis", J Am Soc Nephrol, 23, pp.556~566 (2012)
- Hao J, "The association between anti-plasminogen antibodies and disease activity in ANCAassociated vasculitis", Rheumatology(Oxford), 53, pp.300~306 (2014)
- Suzuki K, "Proposal of anti-moesin as a novel biomarker for ANCA-associated vasculitis", Clin Exp Nephrol, 17, pp.638~641 (2013)
- Simon A, "Detection of anti-pentraxin-3 autoantibodies in ANCA-associated vasculitis", PLoS One, 11, pp.e0147091~ (2016)
- Nagai M, "Serum levels of BAFF and APRIL in myeloperoxidase anti-neutrophil cytoplasmic autoantibody-associated renal vasculitis : association with disease activity", Nephron Clin Pract, 118, pp.c339~45 (2011)
- London J, "Skewed peripheral B- and T-cell compartments in patients with ANCA-associated vasculitis", Rheumatology (Oxford) (2020)[DOI]
- Brilland B, "Complement alternative pathway in ANCA-associated vasculitis : two decades from bench to bedside", Autoimmun Rev, 19, pp.102424~ (2020)
- Kraaij T, "Excessive neutrophil extracellular trap formation in ANCA-associated vasculitis is independent of ANCA", Kidney Int, 94, pp.139~149 (2018)
- Söderberg D, "Increased levels of neutrophil extracellular trap remnants in the circulation of patients with small vessel vasculitis, but an inverse correlation to anti-neutrophil cytoplasmic antibodies during remission", Rheumatology(Oxford), 54, pp.2085~2094 (2015)
- Tedesco M, "Update on ANCA-associated vasculitis : from biomarkers to therapy", J Nephrol, 32, pp.871~882 (2019)
- Burska A, "Cytokines as biomarkers in rheumatoid arthritis", Mediators Inflamm, 2014, pp.545493~ (2014)
- Stypin´ska B, "Cytokines and microRNAs as candidate biomarkers for systemic lupus erythematosus", Int J Mol Sci, 16, pp.24194~24218 (2015)
- Berti A, "The association of serum interleukin-6 levels with clinical outcomes in antineutrophil cytoplasmic antibody-associated vasculitis", J Autoimmun, 105, pp.102302~ (2019)
- Wang Y, "Reduced activated regulatory T cells and imbalance of Th17", activated Treg cells marks renal involvement in ANCA-associated vasculitis, 2020, pp.118, 19~29
- Berti A, "Brief report : circulating cytokine profiles and antineutrophil cytoplasmic antibody specificity in patients with antineutrophil cytoplasmic antibody-associated vasculitis", Arthritis Rheumatol, 70, pp.1114~1121 (2018)
- Kim MK, "Multivariable index for assessing the activity and predicting all-cause mortality in antineutrophil cytoplasmic antibody-associated vasculitis", J Clin Lab Anal, 34, pp.e23022~ (2020)
- Iwai N, "Neutrophil to lymphocyte ratio predicts prognosis in unresectable pancreatic cancer", Sci Rep, 10, pp.18758~ (2020)
- Wu M, "Preoperative plus postoperative neutrophil-lymphocyte ratio for predicting overall survival following partial hepatectomy for hepatocellular carcinoma", Oncol Lett, 20, pp.375~ (2020)
- Firizal AS, "Cut off point of neutrophil-tolymphocyte ratio as a marker of active disease in systemic lupus erythematosus", Lupus, 29, pp.1566~1570 (2020)
- Chandrashekara S, "Potential of neutrophil to lymphocyte ratio in predicting sustained remission in rheumatoid arthritis compared to other immune activation markers", Indian J Med Res, 152, pp.234~243 (2020)
- Coskun Kaya, "HALP score and albumin levels in men with prostate cancer and benign prostate hyperplasia", International Journal of Clinical Practice, 75(3) (2021), Hindawi Limited[DOI]
- Zhang CC, "Preoperative inversed albumin-to-globulin ratio predicts worse oncologic prognosis following curative hepatectomy for hepatocellular carcinoma", Cancer Manag Res, 12, pp.9929~9939 (2020)
- Chung JW, "The prognostic role of preoperative serum albumin", globulin ratio in patients with non-metastatic renal cell carcinoma undergoing partial or radical nephrectomy, 2020, pp.10, 11999~
- Stohl W, "Elevated serum globulin gap as a highly reliable marker of elevated erythrocyte sedimentation rate in patients with systemic rheumatic diseases", Semin Arthritis Rheum, 49, pp.485~492 (2019)
- Kim HJ, "Mean platelet volume can estimate the current vasculitis activity of microscopic polyangiitis", Rheumatol Int, 38, pp.1095~1101 (2018)
- Mun CH, "Atializumab, a humanized anti-aminoacyl-tRNA synthetase-interacting multifunctional protein-1(AIMP1)antibody significantly improves nephritis in(NZB", NZW)F1 mice, 2019, pp.220, 119408~
- Ahn SS, "Serum aminoacyl-tRNA synthetase-interacting multifunctional protein-1can predict severe antineutrophil cytoplasmic antibody-associated vasculitis : a pilot monocentric study", Biomed Res Int, 2019, pp.7508240~ (2019)
- Tangye SG, "Regulation of the germinal center and humoral immunity by interleukin-21", J Exp Med, 217, pp.e20191638~ (2020)
- Yoon T, "Serum interleukin-21positivity could indicate the current activity of antineutrophil cytoplasmic antibody-associated vasculitis : a monocentric prospective study", Clin Rheumatol, 38, pp.1685~1690 (2019)
- Keir ME, "PD-1 and its ligands in tolerance and immunity", Annu Rev Immunol, 26, pp.677~704 (2008)
- Nielsen C, "Alternative splice variants of the human PD-1 gene", Cell Immunol, 235, pp.109~116 (2005)
- Yoon T, "Serum soluble programmed cell death protein 1 could predict the current activity and severity of antineutrophil cytoplasmic antibody-associated vasculitis : a monocentric prospective study", Clin Exp Rheumatol, 37(Suppl 117), pp.116~121 (2019)
- Wilson KC, "The effect of interleukin-16 and its precursor on T lymphocyte activation and growth", Growth Factors, 22, pp.97~104 (2004)
- Yoon T, "Serum interleukin-16 significantly correlates with the Vasculitis Damage Index in antineutrophil cytoplasmic antibody-associated vasculitis", Arthritis Res Ther, 22, pp.73~ (2020)
- Chen M, "LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells : implications in endothelial dysfunction and atherosclerosis", Pharmacol Ther, 95, pp.89~100 (2002)
- Pirillo A, "Soluble lectin-like oxidized low density lipoprotein receptor-1 as a biochemical marker for atherosclerosisrelated diseases", Dis Markers, 35, pp.413~418 (2013)
- Ishikawa M, "Lectin-like oxidized low-density lipoprotein receptor 1 signal is a potent biomarker and therapeutic target for human rheumatoid arthritis", Arthritis Rheum, 64, pp.1024~1034 (2012)
- 윤태준, "Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor 1 Is Inversely Correlated with the Activity of ANCA-Associated Vasculitis", Yonsei Medical Journal, 61(8), pp.720~725 (2020), 연세대학교의과대학[DOI]
- Pa˛gowska-Klimek I, "Mannan-binding lectin in cardiovascular disease", Biomed Res Int, 2014, pp.616817~ (2014)
- Yoon T, "Serum mannose-binding lectin levels are correlated with the disease activity of antineutrophil cytoplasmic antibody-associated vasculitis : a single-center study", Tohoku J Exp Med, 251, pp.117~123 (2020)
- Field D, "Performance evaluation of the immature granulocyte parameter on the Sysmex XE-2100 automated hematology analyzer", Lab Hematol, 12, pp.11~14 (2006)
- 유주영, "Delta Neutrophil Index Is Associated with Vasculitis Activity and Risk of Relapse in ANCA-Associated Vasculitis", Yonsei Medical Journal, 59(3), pp.397~405 (2018), 연세대학교의과대학[DOI]
- Luo R, "Prognostic value of red blood cell distribution width in non-cardiovascular critically or acutely patients : a systematic review", PLoS One, 11, pp.e0167000~ (2016)
- Rodríguez-Carrio J, "Red cell distribution width is associated with cardiovascular risk and disease parameters in rheumatoid arthritis", Rheumatology(Oxford), 54, pp.641~646 (2015)
- 김호재, "Red Blood Cell Distribution Width Can Predict Vasculitis Activity and Poor Prognosis in Granulomatosis with Polyangiitis", Yonsei Medical Journal, 59(2), pp.294~302 (2018), 연세대학교의과대학[DOI]
- 문재승, "C-Reactive Protein to Serum Albumin Ratio Is an Independent Predictor of All-Cause Mortality in Patients with ANCA-Associated Vasculitis", Yonsei Medical Journal, 59(7), pp.865~871 (2018), 연세대학교의과대학[DOI]
- Schulze-Koops H, "Lymphopenia and autoimmune diseases", Arthritis Res Ther, 6, pp.178~180 (2004)
- Ahn SS, "Neutrophil to lymphocyte ratio at diagnosis can estimate vasculitis activity and poor prognosis in patients with ANCA-associated vasculitis : a retrospective study", BMC Nephrol, 19, pp.187~ (2018)
- Armen Yuri Gasparyan, "The Platelet-to-Lymphocyte Ratio as an Inflammatory Marker in Rheumatic Diseases", Annals of Laboratory Medicine, 39(4), pp.345~357 (2019), 대한진단검사의학회[DOI]
- Park HJ, "Platelet to lymphocyte ratio is associated with the current activity of ANCA-associated vasculitis at diagnosis : a retrospective monocentric study", Rheumatol Int, 38, pp.1865~1871 (2018)
- Xu PC, "Hypoalbuminaemia in antineutrophil cytoplasmic antibody-associated vasculitis : incidence and significance", Clin Exp Rheumatol, 36, pp.603~611 (2018)
- O’Connell TX, "Understanding and interpreting serum protein electrophoresis", Am Fam Physician, 71, pp.105~112 (2005)
- Ahn SS, "Clinical role of albumin to globulin ratio in microscopic polyangiitis : a retrospective monocentric study", Clin Rheumatol, 38, pp.487~494 (2019)
- Nakagomi A, "Nutritional status is associated with inflammation and predicts a poor outcome in patients with chronic heart failure", J Atheroscler Thromb, 23, pp.713~727 (2016)
- 안성수, "Controlling Nutritional Status Score is Associated with All-Cause Mortality in Patients with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis", Yonsei Medical Journal, 60(12), pp.1164~1173 (2019), 연세대학교의과대학[DOI]
- Hu B, "Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma", Clin Cancer Res, 20, pp.6212~6222 (2014)
- Kim Y, "Systemic immune-inflammation index could estimate the cross-sectional high activity and the poor outcomes in immunosuppressive drug-naïve patients with antineutrophil cytoplasmic antibody-associated vasculitis", Nephrology(Carlton), 24, pp.711~717 (2019)
- Peng D, "Prognostic significance of HALP(hemoglobin, albumin, lymphocyte and platelet)in patients with bladder cancer after radical cystectomy", Sci Rep, 8, pp.794~ (2018)
- Park PG, "Will the HALP score help to assess the activity and predict the prognosis of antineutrophil cytoplasmic antibody-associated vasculitis?", Clin Exp Rheumatol, 38(Suppl 124), pp.236~237 (2020)
- Wu TT, "Atherogenic index of plasma(AIP) : a novel predictive indicator for the coronary artery disease in postmenopausal women", Lipids Health Dis, 17, pp.197~ (2018)
- Ahn SS, "Atherogenic index of plasma predicts cerebrovascular accident occurrence in antineutrophil cytoplasmic antibody-associated vasculitis", Lipids Health Dis, 19, pp.184~ (2020)
