Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor 1 Is Inversely Correlated with the Activity of ANCA-Associated Vasculitis
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Lectin-like oxidized low-density lipoprotein (LDL) receptor 1 (LOX1) binds to oxidized LDL, which is associated with inflammationin various vascular disorders. Here, we aimed to investigate the potential of soluble LOX1 (sLOX1) as an indicator of antineutrophilcytoplasmic antibody-associated vasculitis (AAV) activity. Serum levels of sLOX1 in frozen samples from patients withAAV enrolled in a prospective observational cohort study at the Severance Hospital were measured using enzyme-linked immunosorbentassay. Clinical and laboratory data were collected on the date when the blood sampling was performed. The associationbetween sLOX1 and clinical and laboratory data was assessed using Pearson’s correlation analysis. The median age of the recruited79 patients was 62.0 years, and 27 (34.2%) patients were men. The median Birmingham vasculitis activity score (BVAS),five-factor score, vasculitis damage index, and sLOX1 level were 6, 1, 3, and 911.9 pg/mL, respectively. Correlation analysis basedon BVAS revealed that sLOX1 and total cholesterol were significantly inversely correlated with BVAS (r=-0.224, p=0.047 and r=-0.424, p<0.001, respectively). No significant correlations were observed between continuous variables and sLOX1 except forBVAS, although total cholesterol tended to correlate with sLOX1 (r=0.190, p=0.093). Additionally, sLOX1 was not influenced by sex,hypertension, diabetes mellitus, or the presence of pulmonary, cardiovascular, and renal involvement of AAV. In summary, sLOX1was inversely correlated with BVAS in AAV patients, which is different from other vascular diseases or inflammatory diseases.
Abstract
Lectin-like oxidized low-density lipoprotein (LDL) receptor 1 (LOX1) binds to oxidized LDL, which is associated with inflammationin various vascular disorders. Here, we aimed to investigate the potential of soluble LOX1 (sLOX1) as an indicator of antineutrophilcytoplasmic antibody-associated vasculitis (AAV) activity. Serum levels of sLOX1 in frozen samples from patients withAAV enrolled in a prospective observational cohort study at the Severance Hospital were measured using enzyme-linked immunosorbentassay. Clinical and laboratory data were collected on the date when the blood sampling was performed. The associationbetween sLOX1 and clinical and laboratory data was assessed using Pearson’s correlation analysis. The median age of the recruited79 patients was 62.0 years, and 27 (34.2%) patients were men. The median Birmingham vasculitis activity score (BVAS),five-factor score, vasculitis damage index, and sLOX1 level were 6, 1, 3, and 911.9 pg/mL, respectively. Correlation analysis basedon BVAS revealed that sLOX1 and total cholesterol were significantly inversely correlated with BVAS (r=-0.224, p=0.047 and r=-0.424, p<0.001, respectively). No significant correlations were observed between continuous variables and sLOX1 except forBVAS, although total cholesterol tended to correlate with sLOX1 (r=0.190, p=0.093). Additionally, sLOX1 was not influenced by sex,hypertension, diabetes mellitus, or the presence of pulmonary, cardiovascular, and renal involvement of AAV. In summary, sLOX1was inversely correlated with BVAS in AAV patients, which is different from other vascular diseases or inflammatory diseases.
참고문헌 (16)
- Chen M, "LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells : implications in endothelial dysfunction and atherosclerosis", Pharmacol Ther, 95, pp.89~100 (2002)
- Kattoor AJ, "LOX-1: regulation, signaling and its role in atherosclerosis", Antioxidants(Basel), 8, pp.218~ (2019)
- Pirillo A, "Soluble lectin-like oxidized low density lipoprotein receptor-1 as a biochemical marker for atherosclerosisrelated diseases", Dis Markers, 35, pp.413~418 (2013)
- Smirnova IV, "Upregulation of lectinlike oxidized low-density lipoprotein receptor-1(LOX-1)in endothelial cells by nitric oxide deficiency", Am J Physiol Renal Physiol, 287, pp.F25~F32 (2004)
- Ishikawa M, "Lectin-like oxidized low-density lipoprotein receptor 1signal is a potent biomarker and therapeutic target for human rheumatoid arthritis", Arthritis Rheum, 64, pp.1024~1034 (2012)
- Watts R, "Development and validation of a consensus methodology for the classification of the ANCA-associated vasculitides and polyarteritis nodosa for epidemiological studies", Ann Rheum Dis, 66, pp.222~227 (2007)
- Jennette JC, "2012 Revised International Chapel Hill Consensus Conference nomenclature of vasculitides", Arthritis Rheum, 65, pp.1~11 (2013)
- Jennette JC, "Pathogenesis of antineutrophil cytoplasmic autoantibody-mediated disease", Nat Rev Rheumatol, 10, pp.463~473 (2014)
- Mukhtyar C, "Modification and validation of the Birmingham Vasculitis Activity Score(version 3)", Ann Rheum Dis, 68, pp.1827~1832 (2009)
- Guillevin L, "The five-factor score revisited: assessment of prognoses of systemic necrotizing vasculitides based on the French Vasculitis Study Group (FVSG) cohort", Medicine(Baltimore), 90, pp.19~27 (2011)
- Bhamra K, "Damage assessment in ANCA-associated vasculitis", Curr Rheumatol Rep, 14, pp.494~500 (2012)
- Han CW, "Development of the Korean version of Short-Form 36-Item Health Survey : health related QOL of healthy elderly people and elderly patients in Korea", Tohoku J Exp Med, 203, pp.189~194 (2004)
- Ozyazgan S, "Lectin-like oxidised LDL receptor-1 as a marker of endothelial dysfunction in Behçet’s disease", Clin Exp Rheumatol, 31(3 Suppl 77), pp.71~76 (2013)
- Liao KP, "The association between reduction in inflammation and changes in lipoprotein levels and HDL cholesterol efflux capacity in rheumatoid arthritis", J Am Heart Assoc, 4, pp.e001588~ (2015)
- Wallace ZS, "Disease activity, antineutrophil cytoplasmic antibody type, and lipid levels in antineutrophil cytoplasmic antibody-associated vasculitis", Arthritis Rheumatol, 71, pp.1879~1887 (2019)
- Petermann Smits DR, "Metabolic syndrome in ANCAassociated vasculitis", Rheumatology(Oxford), 52, pp.197~203 (2013)