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Update on the Classification Criteria for Vasculitis
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초록
The systemic vasculitides are a group of diverse diseases characterized by blood vessel inflammation. The existing classificationcriteria are intended to create homogeneous patient groups for research and not to diagnose individual patients. However, they havebeen misused as diagnostic criteria, in both practice and research. The existing classification systems for vasculitis are limited bythe overlapping features of disease entities and unrecognized pathogenic mechanisms. This review discusses the benefits and limitationsof the widely used American College of Rheumatology criteria and Chapel Hill Consensus Conference nomenclature, updatedin 2012. Improved diagnostics, including antineutrophil cytoplasmic antibody (ANCA) testing and imaging, argue for updatingthe established classification criteria. International efforts are underway to build a more effective classification and diagnosticcriteria that reflect a better understanding of the pathophysiology of vasculitis and recent discoveries of genetics and biomarkers.
Abstract
The systemic vasculitides are a group of diverse diseases characterized by blood vessel inflammation. The existing classificationcriteria are intended to create homogeneous patient groups for research and not to diagnose individual patients. However, they havebeen misused as diagnostic criteria, in both practice and research. The existing classification systems for vasculitis are limited bythe overlapping features of disease entities and unrecognized pathogenic mechanisms. This review discusses the benefits and limitationsof the widely used American College of Rheumatology criteria and Chapel Hill Consensus Conference nomenclature, updatedin 2012. Improved diagnostics, including antineutrophil cytoplasmic antibody (ANCA) testing and imaging, argue for updatingthe established classification criteria. International efforts are underway to build a more effective classification and diagnosticcriteria that reflect a better understanding of the pathophysiology of vasculitis and recent discoveries of genetics and biomarkers.
참고문헌 (41)
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