Appropriate Antigen Concentrations and Timing of a Nasal Provocation Test
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Purpose: We aimed to determine appropriate antigen concentrations and the right time to evaluate intranasal changes when performinga nasal provocation test (NPT). Also, we sought to analyze the diagnostic usefulness of individual nasal symptom and peaknasal inspiratory flow (PNIF). Materials and Methods: We divided 46 patients into allergic rhinitis (AR) group (n=19) and a non-allergic rhinitis (NAR) group(n=27). We performed intranasal challenge with 100 AU/mL of Dermatophagoides pteronyssinus (DP) and measured changes innasal symptoms [scored using the visual analogue scale (VAS)] and PNIF%. If the patient showed significant changes, VAS andPNIF were assessed again after another 15 minutes. In patients without significant changes, we administered 1000 AU/mL andmeasured changes in nasal symptoms and PNIF% after 15 and 30 minutes. Results: Fifteen minutes after the 100 AU/mL challenge, the AR group showed more significant VAS changes in all nasal symptoms,total nasal symptom score (TNSS), and PNIF% change than the NAR group. Among the AR group, patients who did not respondto 100 AU/mL exhibited less significant differences relative to the NAR group, even after 1000 AU/mL challenge. Receiveroperating characteristic curve analysis for VAS changes 15 minutes after 100 AU/mL challenge revealed that all nasal symptomshad area under the curve (AUC) values of ≥0.84 (p<0.001). TNSS change had an AUC value of 0.929 (p<0.001), while PNIF% changehad an AUC value of 0.834. Conclusion: We could determine the optimal concentration (100 AU/mL), timing (15 minutes after challenge), and parameters(changes in TNSS and PNIF%) when performing NPT.
Abstract
Purpose: We aimed to determine appropriate antigen concentrations and the right time to evaluate intranasal changes when performinga nasal provocation test (NPT). Also, we sought to analyze the diagnostic usefulness of individual nasal symptom and peaknasal inspiratory flow (PNIF). Materials and Methods: We divided 46 patients into allergic rhinitis (AR) group (n=19) and a non-allergic rhinitis (NAR) group(n=27). We performed intranasal challenge with 100 AU/mL of Dermatophagoides pteronyssinus (DP) and measured changes innasal symptoms [scored using the visual analogue scale (VAS)] and PNIF%. If the patient showed significant changes, VAS andPNIF were assessed again after another 15 minutes. In patients without significant changes, we administered 1000 AU/mL andmeasured changes in nasal symptoms and PNIF% after 15 and 30 minutes. Results: Fifteen minutes after the 100 AU/mL challenge, the AR group showed more significant VAS changes in all nasal symptoms,total nasal symptom score (TNSS), and PNIF% change than the NAR group. Among the AR group, patients who did not respondto 100 AU/mL exhibited less significant differences relative to the NAR group, even after 1000 AU/mL challenge. Receiveroperating characteristic curve analysis for VAS changes 15 minutes after 100 AU/mL challenge revealed that all nasal symptomshad area under the curve (AUC) values of ≥0.84 (p<0.001). TNSS change had an AUC value of 0.929 (p<0.001), while PNIF% changehad an AUC value of 0.834. Conclusion: We could determine the optimal concentration (100 AU/mL), timing (15 minutes after challenge), and parameters(changes in TNSS and PNIF%) when performing NPT.
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