Relationship between Androgen Deprivation Therapy and Normal-Tension Glaucoma in Patients with Prostate Cancer: A Nationwide Cohort Study
1
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Purpose: This study assessed the relationship between newly developed normal-tension glaucoma (NTG) and androgen depri vation therapy (ADT) in patients with prostate cancer. Materials and Methods: A retrospective population-based cohort study was performed. During the period between 2008 and 2017, a total of 218203 prostate cancer patients were identified in a nationwide claims database in the Republic of Korea. The final analysis included 170874 patients (42909 in the ADT group, 127965 in the control group) after applying the inclusion and exclusion criteria. The incidences of NTG according to ADT duration were compared with controls. Exact matching was conducted to adjust comorbidities between cohorts. Cox proportional hazard regression models were performed after controlling for latent confound ing factors, and adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for the incidence of NTG according to ADT were obtained. Results: In the matched cohort, the ADT group was associated with a significantly reduced risk of NTG in multivariable analysis compared to the control group. The risk of NTG decreased in patients who underwent ADT for less than 2 years (HR=0.824; 95% CI, 0.682–0.995; p=0.0440) and in those using ADT over 2 years (HR=0.796; 95% CI, 0.678–0.934; p=0.0051), compared to the controls. Conclusion: Medical castrations for patients with prostate cancer results in a lower incidence of newly diagnosed NTG compared to no ADT. These findings suggest that testosterone may be involved in the pathogenesis of NTG.
Abstract
Purpose: This study assessed the relationship between newly developed normal-tension glaucoma (NTG) and androgen depri vation therapy (ADT) in patients with prostate cancer. Materials and Methods: A retrospective population-based cohort study was performed. During the period between 2008 and 2017, a total of 218203 prostate cancer patients were identified in a nationwide claims database in the Republic of Korea. The final analysis included 170874 patients (42909 in the ADT group, 127965 in the control group) after applying the inclusion and exclusion criteria. The incidences of NTG according to ADT duration were compared with controls. Exact matching was conducted to adjust comorbidities between cohorts. Cox proportional hazard regression models were performed after controlling for latent confound ing factors, and adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for the incidence of NTG according to ADT were obtained. Results: In the matched cohort, the ADT group was associated with a significantly reduced risk of NTG in multivariable analysis compared to the control group. The risk of NTG decreased in patients who underwent ADT for less than 2 years (HR=0.824; 95% CI, 0.682–0.995; p=0.0440) and in those using ADT over 2 years (HR=0.796; 95% CI, 0.678–0.934; p=0.0051), compared to the controls. Conclusion: Medical castrations for patients with prostate cancer results in a lower incidence of newly diagnosed NTG compared to no ADT. These findings suggest that testosterone may be involved in the pathogenesis of NTG.
참고문헌 (21)
- Huggins C, "Studies on prostatic cancer", Cancer Res, 1, pp.293~297 (1941)
- Meng MV, "Contemporary patterns of androgen deprivation therapy use for newly diagnosed prostate cancer", Urology, 60(3 Suppl 1), pp.7~11 (2002)
- Mitsuzuka K, "Metabolic changes in patients with prostate cancer during androgen deprivation therapy", Int J Urol, 25, pp.45~53 (2018)
- Borno HT, "Differential use of medical versus surgical androgen deprivation therapy for patients with metastatic prostate cancer", Cancer, 125, pp.453~462 (2019)
- Weinreb RN, "The pathophysiology and treatment of glaucoma : a review", JAMA, 311, pp.1901~1911 (2014)
- Quigley HA, "The number of people with glaucoma worldwide in 2010 and 2020", Br J Ophthalmol, 90, pp.262~267 (2006)
- Cho HK, "Population-based glaucoma prevalence studies in Asians", Surv Ophthalmol, 59, pp.434~447 (2014)
- Tham YC, "Global prevalence of glaucoma and projections of glaucoma burden through 2040 : a systematic review and meta-analysis", Ophthalmology, 121, pp.2081~2090 (2014)
- Zetterberg M, "Age-related eye disease and gender", Maturitas, 83, pp.19~26 (2016)
- Patel P, "Effects of sex hormones on ocular blood flow and intraocular pressure in primary open-angle glaucoma : a review", J Glaucoma, 27, pp.1037~1041 (2018)
- Ahn HK, "Androgen deprivation therapy may reduce the risk of primary openangle glaucoma in patients with prostate cancer : a nationwide population-based cohort study", Prostate Int, 9, pp.197~202 (2021)
- Killer HE, "Normal tension glaucoma: review of current understanding and mechanisms of the pathogenesis", Eye(Lond), 32, pp.924~930 (2018)
- Kim KE, "Update on the prevalence, etiology, diagnosis, and monitoring of normal-tension glaucoma", Asia Pac J Ophthalmol(Phila), 5, pp.23~31 (2016)
- 김지애, "Towards Actualizing the Value Potential of Korea Health Insurance Review and Assessment (HIRA) Data as a Resource for Health Research: Strengths, Limitations, Applications, and Strategies for Optimal Use of HIRA Data", Journal of Korean Medical Science, 32(5), pp.718~728 (2017), 대한의학회
- Nead KT, "Androgen deprivation therapy and future Alzheimer’s disease risk", J Clin Oncol, 34, pp.566~571 (2016)
- Kang JH, "Sex hormone levels and risk of primary open-angle glaucoma in postmenopausal women", Menopause, 25, pp.1116~1123 (2018)
- Rudnicka AR, "Variations in primary open-angle glaucoma prevalence by age, gender, and race : a Bayesian meta-analysis", Invest Ophthalmol Vis Sci, 47, pp.4254~4261 (2006)
- Racette L, "Primary open-angle glaucoma in blacks : a review", Surv Ophthalmol, 48, pp.295~313 (2003)
- Bonomi L, "Prevalence of glaucoma and intraocular pressure distribution in a defined population. The Egna-Neumarkt Study", Ophthalmology, 105, pp.209~215 (1998)
- Gaston KE, "Racial differences in androgen receptor protein expression in men with clinically localized prostate cancer", J Urol, 170, pp.990~993 (2003)
- Nguyen PL, "Adverse effects of androgen deprivation therapy and strategies to mitigate them", Eur Urol, 67, pp.825~836 (2015)