The Relationship between Vitamin D and Glaucoma: A Kangbuk Samsung Health Study
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Purpose: To investigate the relationship between vitamin D and glaucoma. Methods: This retrospective, cross-sectional study included subjects who underwent a health screening atthe Health Screening Center of Kangbuk Samsung Hospital from August 2012 to July 2013. All fundus photographswere reviewed by ophthalmologists. The ophthalmologists determined if an eye was glaucomatousbased on the criteria set forth by the International Society of Geographical and Epidemiological Ophthalmologyand by the appearance of the retinal nerve fiber layer and optic disc. If the subjects previously underwentan ophthalmologic examination, they were enrolled based on the documented history. In addition to fundusphotographs, each participant underwent a systemic examination including blood sampling and sociodemographicand behavioral questionnaires. The subjects were divided into five groups according to serum 25-hydroxyvitaminD (25(OH)D) level. Multivariate logistic regression models were constructed to assess possibleassociations between elevated glaucoma risk and systemic factors with a p < 0.2 on univariate analysis. Results: Of the 169,208 subjects older than 20 years, 123,331 were eligible for the study. There was no differencein the prevalence of glaucoma according to quintile of serum 25(OH)D level based on sex (p = 0.412 formales, p = 0.169 for females). According to the multivariable-adjusted logistic analysis, the odds ratio of glaucomafor the fourth quintile was significantly lower than that of the first quintile in females (odds ratio, 0.713;95% confidence interval, 0.520 to 0.979). Conclusions: Lower 25(OH)D level was significantly associated with an elevated risk of glaucoma in femalescompared with higher 25(OH)D level. Further evaluation is needed to investigate the relationship betweenglaucoma and vitamin D.
Abstract
Purpose: To investigate the relationship between vitamin D and glaucoma. Methods: This retrospective, cross-sectional study included subjects who underwent a health screening atthe Health Screening Center of Kangbuk Samsung Hospital from August 2012 to July 2013. All fundus photographswere reviewed by ophthalmologists. The ophthalmologists determined if an eye was glaucomatousbased on the criteria set forth by the International Society of Geographical and Epidemiological Ophthalmologyand by the appearance of the retinal nerve fiber layer and optic disc. If the subjects previously underwentan ophthalmologic examination, they were enrolled based on the documented history. In addition to fundusphotographs, each participant underwent a systemic examination including blood sampling and sociodemographicand behavioral questionnaires. The subjects were divided into five groups according to serum 25-hydroxyvitaminD (25(OH)D) level. Multivariate logistic regression models were constructed to assess possibleassociations between elevated glaucoma risk and systemic factors with a p < 0.2 on univariate analysis. Results: Of the 169,208 subjects older than 20 years, 123,331 were eligible for the study. There was no differencein the prevalence of glaucoma according to quintile of serum 25(OH)D level based on sex (p = 0.412 formales, p = 0.169 for females). According to the multivariable-adjusted logistic analysis, the odds ratio of glaucomafor the fourth quintile was significantly lower than that of the first quintile in females (odds ratio, 0.713;95% confidence interval, 0.520 to 0.979). Conclusions: Lower 25(OH)D level was significantly associated with an elevated risk of glaucoma in femalescompared with higher 25(OH)D level. Further evaluation is needed to investigate the relationship betweenglaucoma and vitamin D.
참고문헌 (36)
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