본문 바로가기
KERD
논문KCI 등재

Development of resistance to reinfection by Clonorchis sinensis in rats

홍성태|최민호|전동규|Hongman Zhang|Shunyu Li|정병석|이매정
대한기생충학ㆍ열대의학회 (The Korean Society For Parasitology and Tropical Medicine)|2004.03|Parasites, Hosts and Diseases|제42권 제1호|pp. 19-26

2

조회

0

다운로드

1

인용

0

참고문헌

주제분류예방의학/직업환경의학

초록

Abstract

We investigated the induction of resistance to Clonorchis sinensis infection by prior infection in rat and hamster models. Animals were challenged with C. sinensis metacercariae, then treated with praziquantel and reinfected. Worm recovery rate in reinfected animals was used to estimate resistance to reinfection. The determined resistance rates to reinfection in rats and hamsters were 97.7% and 10.3%, respectively. In rats, cure from the primary infection of C. sinensis increased resistant to reinfection, and the greatert the worm burden and the longer the duration of primary infection, the higher was the resistance rate. For primary infection doses of 10, 40 and 100 metacercariae per rat, the resistance rates were 87.4%, 93.8% and 98.4%, respectively. The resistance rates in rats after 2 or 8-week primary infection were 78.7% and 95.3%, respectively. All worms recovered from reinfected rats were immature. When cured rats were administered with methylprednisolone, resistance to reinfection became impaired. These findings indicate that rats develop a high degree of resistance to reinfection by C. sinensis after cure possibly due to immunity acquired from the primary infection. The growths and maturations of reinfected worms were also impaired.

참고문헌 (21)

  1. "Migration of newly excysted juveniles in resistant rats", pp.277~288 (1983)
  2. "Susceptibility and resistance to Schistosoma mansoni reinfection: parallel cellular and isotypic immunologic assessment", 62, pp.57~64 (2000)
  3. "mice and men-models for immune effector mechanisms against schistosomiasis", pp.69~75 (1986)
  4. "Profiles of Th1 and Th2 cytokines after primary and secondary infection by Schistosoma mansoni in the semipermissive rat host", 67, pp.2713~2719 (1999)
  5. "Progress in assessment of morbidity due to Clonorchis sinensis infection a review of recent literature" (1994)
  6. "Cytokine responses in mice infected with Clonorchis sinensis", 91, pp.87~93 (2003)
  7. "How much human helminthiasis is there in the world?", 85, pp.397~403 (1999)
  8. "Resistance of the rat to reinfection with Fasciola hepatica and the possible involvement of intestinal eosinophil leucocytes", pp.41~44 (1978)
  9. "Acquired resistance to Opisthorchis viverrini in the hamster", pp.800~802 (1982)
  10. "IgG4 and resistance to reinfection with Schistosoma haematobium", pp.243~349 245 (1991)
  11. "Egg positive rates of Clonorchis sinensis and intestinal helminths among residents in Kagye-ri", pp.271~273 (1994)
  12. "Oesophagostomum species in pigs in England resistance to reinfection", pp.551~555 (1977)
  13. "Mechanisms of resistance to S. mansoni infection: the rat model", 49, pp.339~345 (2000)
  14. "Heterogeneity of the "oval-cell" response in the hamster liver during cholangiocarcinogenesis following Clonorchis sinensis infection and dimethylnitrosamine treatment", 26, pp.1313~1323 (1997)
  15. "Chemotherapeutic efficacy of praziquantel in rats with protective immunity to Clonorchis sinensis infection", 18, pp.98~102 (2000)
  16. "The current pathobiology and chemotherapy of clonorchiasis", pp.3~141 (1986)
  17. "An epidemiologic study on clonorchiasis and metagonimiasis In riverside areas In Korea", pp.137~150 (1981)
  18. "Attempts to induce protective immunity in hamsters against infection by a liver fluke of man", pp.127~86 1 136 (1983)
  19. "Oesophagostomum spp. in pigs: resistance to reinfection", 84, pp.783~786 (1998)
  20. "Liver fluke-associated cholangiocarcinoma", 89, pp.962~970 (2002)
  21. "Infectivity and pathological changes in murine clonorchiasis: comparison in immunocompetent and immunodeficient mice", 63, pp.421~425 (2001)

관련 논문AI추천

Susceptibility of experimental animals to reinfection with Clonorchis sinensis손운목, 최민호, 홍성태, Hongman Zhang대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2006 · 제44권 제2호Bile duct changes in rats reinfected with Clonorchis sinensis이순형, 임재훈, 정병석, 최동일, 홍성태, Shunyu Li대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2004 · 제42권 제1호Changing Patterns of Serum and Bile Antibodies in Re-infected Rats with Clonorchis sinensis정병석, 최민호, 홍성태, Hongman Zhang, Shunyu Li대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2008 · 제46권 제1호Organ-specific antigens of Clonorchis sinensis정병석, 최민호, 홍성태, Shunyu Li대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2004 · 제42권 제4호Effects of gamma-irradiation on the infectivity and chromosome aberration of Clonorchis sinensisGab-ManPARK, Tai-SoonYONG대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2003 · 제41권 제1호Changes of cytokine mRNA expression and IgGresponses in rats infected with Capillaria hepatica김동관, 정명숙, 주경환대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2007 · 제45권 제2호

이 간행물의 다른 논문 (6건)

Prevalence of cryptosporidiosis among the villagers and domestic animals in several rural areas of Korea이규재, 유재란, 서민, 손운목, 김동수, 최해연, 허선, 김석일pp. 1-6Bile duct changes in rats reinfected with Clonorchis sinensis홍성태, 임재훈, 정병석, Shunyu Li, 최동일, 이순형pp. 7-17In vitro culture of Cryptosporidium muris in a human stomach adenocarcinoma cell line유재란, 최민호, 채종일, 홍성태, 박우윤pp. 27-34Decreasing effect of an anti-Nfa1 polyclonal antibody on the in vitro cytotoxicity of pathogenic Naegleria fowleri정석률, 강수연, 이상철, 송경주, 신호준, 임경일pp. 35-40Clonorchis sinensis metacercarial infection in the pond smelt Hypomesus olidus and the minnow Zacco platypus collected from the Soyang and Daechung Lakes (Brief Communication)김태윤, 신은희, 박지연, 김재립, 박재환, 국상미, Aifen Lin, 채종일, 홍성태pp. 41-44
원문 보기