본문 바로가기
KERD
논문KCI 등재

Effects of iNOS inhibitor on IFN-gamma production and apoptosis of splenocytes in genetically different strains of mice infected with Toxoplasma gondii

이재호|이계성|최인욱|이영하|신대환|강기만
대한기생충학ㆍ열대의학회 (The Korean Society For Parasitology and Tropical Medicine)|2004.12|Parasites, Hosts and Diseases|제42권 제4호|pp. 175-183

2

조회

0

다운로드

1

인용

0

참고문헌

주제분류예방의학/직업환경의학

초록

Abstract

To evaluate the effects of nitric oxide (NO) on IFN-γ production and apoptosis induction in genetically different strains of mice with toxoplasmosis, BALB/c (a toxoplasmosis resistant strain) and C57BL/6 (a toxoplasmosis susceptible strain) mice were administered T. gondii cysts orally and injected intraperitoneally with aminoguanidine, an iNOS inhibitor (AG; 35 mg/kg per mouse daily for 14 days). No deaths occurred among the AG treated BALB/c mice administered T. gondii, whereas infected and AG-treated C57BL/6 mice survived only a few days. The numbers of brain cysts were significantly greater and the NO and IFN-γ levels in splenocyte culture supernatants were significantly lower in infected and AG-treated C57BL/6 mice than in the infection controls, whereas infected and AG-treated BALB/c mice had parasite burdens, and NO and IFN-γ levels that were similar to those of the infected controls.The apoptotic splenocyte fractions in the infected and AG-treated groups of both mouse strains were not significantly different from those in the infected non-treated controls. These results suggest that NO modulates IFN- production in T. gondii-infected C57BL/6 mice, and that NO is involved in mediating a protective response in toxoplasmosis susceptible mouse strain during acute infection. However, this suggested effect was not apparent in the toxoplasmosis resistant strain.

참고문헌 (22)

  1. "Dynamics of the intracerebral and splenic cytokine mRNA production in Toxoplasma gondii-resistant and -susceptible congenic strains of mice", 85, pp.408~418 (1995)
  2. "T lymphocyte-dependent effector mechanisms of immunity to Toxoplasma gondii", 1, pp.699~708 (1999)
  3. "IFN- overproduction and high level apoptosis are associated with high but not low virulence Toxoplasma gondii infection", 167, pp.902~909 (2001)
  4. "Contribution of nitric oxide to the host parasite equilibrium in toxoplasmosis", 156, pp.1476~1481 (1996)
  5. "Inhibition of apoptosis by intracellular protozoan parasites", 31, pp.1166~1176 (2001)
  6. "Fas-FasL interaction involved in pathogenesis of ocular toxoplasmosis in mice", 67, pp.928~935 (1999)
  7. "Nitric oxide: biology and pathology" (2000), Academic Press
  8. "Role of nitric oxide in parasitic infections", 59, pp.533~547 (1995)
  9. "Toxoplasma infection. In Harrison's Principles of Internal Medicine", pp.1222~1227 (2001), McGraw-Hill Company
  10. "Immune responses of different strains after challenge with equivalent lethal doses of Toxoplasma gondii", 11, pp.89~97 (2004)
  11. "Gamma interferon induces Fas-dependent apoptosis of Peyers patch T cells in mice following peroral infection with Toxoplasma gondii", 65, pp.4682~4689 (1997)
  12. "TNF-,nitric oxide and IFN- are all critical for development of necrosis in the small intestine and early mortality in genetically susceptible mice infected perorally with Toxoplasma gondii", 21, pp.365~376 (1999)
  13. "Gamma interferon modulates CD95 (Fas) and CD95 ligand (Fas-L) expression and nitric oxide-induced apoptosis during the acute phase of Trypanosoma cruzi infection: a possible role in immune response control", 67, pp.3864~3871 (1999)
  14. "Cytokine, nitric oxide, heat shock proteins and virulence in Toxoplasma", 15, pp.418~422 (1999)
  15. "Acute toxoplasmosis leads to lethal overproduction of Th1 cytokines", 167, pp.4574~4584 (2001)
  16. "Biological effects of aminoguanidine: An update", 48, pp.509~515 (1999)
  17. "Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii", 185, pp.1261~1273 (1997)
  18. "Inhibition of inducible nitric oxide synthase exacerbates chronic cerebral toxoplasmosis in Toxoplasma gondii-susceptible C57BL", 6 mice but does not reactivate the latent disease in T. gondii-resistant BALB, pp.1999, 162[DOI]
  19. "Involvement of apoptosis and interferon- in murine toxoplasmosis", 42, pp.2031~2036 (2001)
  20. "Mechanisms underlying the manipulation of host apoptotic pathways by Toxoplasma gondii", 34, pp.381~391 (2004)
  21. "Induction of tumor necrosis factor- and inducible nitric oxide synthase fails to prevent toxoplasmic encephalitis in the absence of interferon- in genetically resistant BALB", c mice, 2000, pp.2, 455~462
  22. "Nitric oxide induction in murine macrophages and spleen cells by whole-cell Bordetella pertussis vaccine", 16, pp.16~23 (1998)

관련 논문AI추천

T cell phenotype and intracellular IFN- γproduction in peritoneal exudate cells and gut intraepithelial lymphocytes during acute Toxoplasma gondii infection in miceDae-WhanSHIN, Young-HaLEE대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2002 · 제40권 제3호Suppression of CD4+ T-Cells in the Spleen of Mice Infected with Toxoplasma gondii KI-1 Tachyzoites김재립, 신은희, 정봉광, 채종일, Seung-Young Yu, Won-Hee Kim대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2010 · 제48권 제4호Parasite Infiltration and Apoptosis in Spleen upon Toxoplasma gondii InfectionFu-Shi Quan, Ki-Back Chu, Su-Hwa Lee대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2019 · 제57권 제5호Cytokine and antibody responses of reactivated murine toxoplasmosis upon administration of dexamethasone강기만, 신대환, 이영하, 최인욱대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2006 · 제44권 제3호Toxoplasma gondi Inhibits Apoptosis in Infected Cells by Caspase Inactivation and NF-κB Activation김지영, 류재숙, 민득영, 안명희, 전혜선, 정재원연세대학교의과대학 · Yonsei Medical Journal2006 · 제47권 제6호Vaccination against Murine Toxoplasmosis Using Recombinant Toxoplasma gondii SAG3 Antigen Alone or in Combination with Quil A남호우, 신대완, 안명희, 이영하, 이재호연세대학교의과대학 · Yonsei Medical Journal2007 · 제48권 제3호

이 간행물의 다른 논문 (7건)

Developmental surface ultrastructure of Macroorchis spinulosus in albino rats우호춘, 홍성종, 권오실pp. 151-157Codon usage and bias in mitochondrial genomes of parasitic platyhelminthesDavid Blair, Le Thanh Hoa, Donald Peter McManuspp. 159-167Organ-specific antigens of Clonorchis sinensis최민호, 홍성태, Shunyu Li, 정병석pp. 169-174Influence of calcium ion on host cell invasion and intracellular replication by Toxoplasma gondii이영하, 민득영, 송현욱, 안명희, 류재숙, 주경환pp. 185-193Immunization effect of recombinant P27/30 protein expressed in Escherichia coli against the hard tick Haemaphysalis longicornis (Acari: Ixodidae) in rabbits유명조pp. 195-200
원문 보기