GRA Proteins of Toxoplasma gondii: Maintenance of Host-Parasite Interactions across the Parasitophorous Vacuolar Membrane
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초록
The dense granule of Toxoplasma gondii is a secretory vesicular organelle of which the proteins participate in the modification of the parasitophorous vacuole (PV) and PV membrane for the maintenance of intracellular parasitism in almost all nucleated host cells. In this review, the archives on the research of GRA proteins are reviewed on the foci of finding GRA proteins, characterizing molecular aspects, usefulness in diagnostic antigen, and vaccine trials in addition to some functions in host-parasite interactions.
Abstract
The dense granule of Toxoplasma gondii is a secretory vesicular organelle of which the proteins participate in the modification of the parasitophorous vacuole (PV) and PV membrane for the maintenance of intracellular parasitism in almost all nucleated host cells. In this review, the archives on the research of GRA proteins are reviewed on the foci of finding GRA proteins, characterizing molecular aspects, usefulness in diagnostic antigen, and vaccine trials in addition to some functions in host-parasite interactions.
참고문헌 (78)
- Ngo HM, "Differential sorting and postsecretory targeting of proteins in parasitic invasion", Trends Cell Biol, 10, pp.67~72 (2000)
- Joiner KA, "Secretory traffic in the eukaryotic parasite Toxoplasma gondii: less is more", J Cell Biol, 157, pp.557~563 (2002)
- Huynh MH, "Rapid invasion of host cells by Toxoplasma requires secretion of the MIC2-M2P adhesive protein complex", EMBO J, 22, pp.2082~2090 (2003)
- Ngo HM, "Are rhoptries in Apicomplexan parasites secretory granules or secretory lysosomal granules?", Mol Microbiol, 52, pp.1531~1542 (2004)
- Lebrun M, "The rhoptry neck protein RON4 re-localizes at the moving junction during Toxoplasma gondii invasion", Cell Microbiol, 7, pp.1823~1833 (2005)
- Besteiro S, "Export of a Toxoplasma gondii rhoptry neck protein complex at the host cell membrane to form the moving junction during invasion", PLoS Pathog, e1000309 (2009)
- Mercier C, "Biogenesis of nanotubular network in Toxoplasma parasitophorous vacuole induced by parasite proteins", Mol Biol Cell, 13, pp.2397~2409 (2002)
- Cesbron-Delauw MF, "Dense granule organelles of Toxoplasma gondii: Their role in the host-parasite relationship", Parasitol Today, 10, pp.293~296 (1994)
- Mercier C, "Dense granules: Are they key organelles to help understand the parasitophorous vacuole of all apicomplexa parasites?", Int J Parasitol, 35, pp.829~849 (2005)
- Ahn HJ, "Host cell binding of GRA10, a novel, constitutively secreted dense granular protein from Toxoplasma gondii", Biochem Biophys Res Commun, 331, pp.614~620 (2005)
- Rome ME, "Intervacuolar transport and unique topology of GRA14, a novel dense granule protein in Toxoplasma gondii", Infect Immun, 76, pp.4865~4875 (2008)
- Michelin A, "GRA12, a Toxoplasma dense granule protein associated with the intravacuolar membraneous nanotubular network", Int J Parasitol, 39, pp.299~306 (2009)
- Johnson M, "The relationship between nucleotide triphosphate hydrolase (NTPase) isoform and Toxoplasma strain virulence in rat and human toxoplasmosis", Microbes Infect, 5, pp.797~806 (2003)
- Morris MT, "Functional analysis of Toxoplasma gondii protease inhibitor I", J Biol Chem, 227, pp.45259~45266 (2002)
- Pszenny V, "Subcellular localization and post-secretory targeting of TgPI, a serine proteinase inhibitor from Toxoplasma gondii", Mol Biochem Parasitol, 121, pp.283~286 (2002)
- Do H, "The cotranslational integration of membrane proteins into the phospholipids bilayer is a multistep process", Cell, 85, pp.369~378 (1996)
- Ossorio PN, "A soluble secretory protein of the intracellular parasite Toxoplasma gondii associates with the parasitophorous vacuole membrane through hydrophobic interaction", J Biol Chem, 269, pp.15350~15357 (1994)
- Henriquez HL, "Identification and characterization of a Toxoplasma gondii protein with a N-terminal portion identical to GRA3" (2002)
- Sibley LD, "Regulated secretion of multi-lamellar vesicles leads to the formation of a tubulo-vesicular network in host cell vacuoles occupied by Toxoplasma gondii", J Cell Sci, 108, pp.1669~1677 (1995)
- Labruyere E, "Differential membrane targeting of the secretory proteins GRA4 and GRA6 within the parasitophorous vacuole formed by Toxoplasma gondii", Mol Biochem Parasitol, 102, pp.311~324 (1999)
- Cesbron-Delauw MF, "Molecular characterization of a 23-kilodalton major antigen secreted by Toxoplasma gondii", Proc Natl Acad Sci, 86, pp.7537~7541 (1989)
- Carruthers VB, "Sequential protein secretion from three distinct organelles of Toxoplasma gondii accompanies invasion of human fibroblasts", Eur J Cell Biol, 73, pp.114~123 (1997)
- Beghetto E, "Identification of a human immunodominant B-cell epitope within the GRA1 antigen of Toxoplasma gondii by phage display of cDNA libraries", Int J Parasitol, 31, pp.1659~1668 (2001)
- Scorza T, "A GRA1 DNA vaccine primes cytolytic CD8(+) T cells to control acute Toxoplasma gondii infection", Infect Immun, 71, pp.309~316 (2003)
- 안혜진, "Interactions between secreted GRA proteins and host cell proteins across the parasitophorous vacuolar membrane in the parasitism of Toxoplasma gondii", The Korean Journal of Parasitology, 44(4), pp.303~312 (2006), 대한기생충학회
- Dubremetz JF, "Kinetics and pattern of organelle exocytosis during Toxoplasma gondii", host-cell interaction, 1993, pp.79, 402~408
- Mercier C, "Molecular characterization of a dense granule antigen (Gra 2) associated with the network of the parasitophorous vacuole in Toxoplasma gondii", Mol Biochem Parasitol, 58, pp.71~82 (1993)
- Zinecker CF, "The dense granule antigen, GRA2 of Toxoplasma gondii is a glycoprotein containing O-linked oligosaccharides", Mol Biochem Parasitol, 97, pp.241~246 (1998)
- Mercier C, "The amphipathic alpha helices of the Toxoplasma protein GRA2 mediate post-secretory membrane association", J Cell Sci, 111, pp.2171~2180 (1998)
- Prigione I, "T cell clones raised from chronically infected healthy humans by stimulation with Toxoplasma gondii excretory- secretory antigens cross-react with live tachyzoites: characterization of the fine antigenic specificity of the clones and implications for vaccine development", J Immunol, 164, pp.3741~3748 (2000)
- Cha DY, "Effects of specific monoclonal antibodies to dense granular proteins on the invasion of Toxoplasma gondii in vitro and in vivo", Korean J Parasitol, 39, pp.233~240 (2001)
- Bermudes D, "Cloning of a cDNA encoding the dense granule protein GRA3 from Toxoplasma gondii", Mol Biochem Parasitol, 68, pp.247~257 (1994)
- Chaturvedi S, "Constitutive calcium-independent release of Toxoplasma gondii dense granules occurs through the NSF", SNAP, Rab machinery, pp.J Biol Chem, 1999[DOI]
- Henriquez FL, "Toxoplasma gondii dense granule protein 3 (GRA3) is a type I transmembrane protein that possesses a cytoplasmic dilysine (KKXX) endoplasmic reticulum (ER) retrieval motif", Parasitology, 131, pp.169~179 (2005)
- Beghetto E, "Molecular dissection of the human B-cell response against Toxoplasma gondii infection by lambda display of cDNA libraries", Int J Parasitol, 33, pp.163~173 (2003)
- Guo S, "Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation", J Biol Chem, 280, pp.12536~12541 (2005)
- Bram RJ, "Calcium signaling in T cells stimulated by a cyclosporine B-binding protein", Nature, 371, pp.355~358 (1994)
- Feng P, "Kaposi’s sarcoma- associated herpesvirus mitochondrial K7 protein targets a cellular calcium-modulating cyclophilin ligand to modulate intracellular calcium concentration and inhibit apoptosis", J Virol, 76, pp.11491~11504 (2002)
- 김지연, "Interaction between Parasitophorous Vacuolar Membraneassociated GRA3 and Calcium Modulating Ligand of Host Cell Endoplasmic Reticulum in the Parasitism of Toxoplasma gondii", The Korean Journal of Parasitology, 46(4), pp.209~216 (2008), 대한기생충학회
- Mevelec MN, "Molecular cloning of GRA4, a Toxoplasma gondii dense granule protein, recognized by mucosal IgA antibodies", Mol Biochem Parasitol, 56, pp.227~238 (1992)
- Chardes T, "Mucosal and systemic cellular immune responses induced by Toxoplasma gondii antigens in cyst orally infected mice", Immunology, 78, pp.421~429 (1993)
- Reichmann G, "Detection of a novel 40,000 MW excretory Toxoplasma gondii antigen by murine Th1 clone which induces toxoplasmacidal activity when exposed to infected macrophages", Immunology, 92, pp.284~289 (1997)
- Mevelec MN, "Mapping of B epitopes in GRA4, a dense granule antigen of Toxoplasma gondii and protection studies using recombinant proteins administered by the oral route", Parasite Immunol, 20, pp.183~195 (1998)
- Desolme B, "Induction of protective immunity against toxoplasmosis in mice by DNA immunization with a plasmid encoding Toxoplasma gondii GRA4 gene", Vaccine, 18, pp.2512~2521 (2000)
- Martin V, "Recombinant GRA4 or ROP2 protein combined with alum or the gra4 gene provides partial protection in chronic murine models of toxoplasmosis", Clin Diagn Lab Immunol, 11, pp.704~710 (2004)
- Mevelec MN, "Evaluation of protective effect of DNA vaccination with genes encoding antigens GRA4 and SAG1 associated with GM-CSF plasmid, against acute, chronical and congenital toxoplasmosis in mice", Vaccine, 23, pp.4489~4499 (2005)
- Pope BJ, "Solution structure of human cofilin: actin binding, pH sensitivity, and relationship to actin-depolymerizing factor", J Biol Chem, 279, pp.4840~4848 (2004)
- Vardouli L, "LIM-kinase 2 and cofilin phosphorylation mediate actin cytoskeleton reorganization induced by transforming growth facter-beta", J Biol Chem, 280, pp.11448~11457 (2005)
- Nebl G, "Dephosphorylation of serine 3 regulates nuclear translocation of cofilin", J Biol Chem, 271, pp.26276~26280 (1996)
- Chua BT, "Mitochondrial translocation of cofilin is an early step in apoptosis induction", Nature Cell Biol, 5, pp.1083~1089 (2003)
- Guo Y, "Tim50, a component of the mitochondrial tranlocator, regulates mitochondrial integrity and cell death", J Biol Chem, 279, pp.24813~24825 (2004)
- Paschen SA, "The role of the TIM8-13 complex in the import of Tim23 into mitochodria", EMBO J, 19, pp.6392~6400 (2000)
- Jensen RE, "Protein import into and across the mitochondrial inner membrane: role of the TIM23 and TIM22 tranlocons", Biochim Biophys Acta, 1592, pp.25~34 (2002)
- Lecordier L, "Molecular structure of a Toxoplasma gondii dense granule antigen (GRA 5) associated with the parasitophorous vacuole membrane", Mol Biochem Parasitol, 59, pp.143~153 (1993)
- Lecordier L, "Transmembrane insertion of the Toxoplasma gondii GRA5 protein occurs after soluble secretion into the host cell", Mol Biol Cell, 10, pp.1277~1287 (1999)
- Angeletti PC, "Small glutamine-rich protein", viral protein U-binding protein is a novel cochaperone that afftects heat shock protein 70 activity, 2002, pp.7, 258~268
- Yin H, "SGT, a Hsp90beta binding parter, is accumulated in the nucleus during cell apoptosis", Biochem Biophys Res Comm, 343, pp.1153~1158 (2006)
- Lecordier L, "Characterization of a dense granule antigen of Toxoplasma gondii (GRA6) associated to the network of the parasitophorous vacuole", Mol Biochem Parasitol, 70, pp.85~94 (1995)
- Fazaeli A, "Molecular typing of Toxoplasma gondii strains by GRA6 gene sequence analysis", Int J Parasitol, 30, pp.637~642 (2000)
- Moser TL, "Endothelial cell surface F1-F0 ATP synthase is active in ATP synthesis and is inhibited by angiostatin", Proc Natl Acad Sci, 98, pp.6656~6661 (2001)
- Coux O, "Structure and functions of the 20S and 26S proteasomes", Annu Rev Biochem, 65, pp.801~847 (1996)
- Apcher GS, "The alpha4 and alpha7 subunits and assembly of the 20S proteasome", FEBS Lett, 569, pp.211~216 (2004)
- Jacobs D, "Identification and heterologous expression of a new dense granule protein (GRA7) from Toxoplasma gondii", Mol Biochem Parasitol, 91, pp.237~249 (1998)
- Fischer HG, "GRA7, an excretory 29 kDa Toxoplasma gondii dense granule antigen released by infected host cells", Mol Biochem Parasitol, 91, pp.251~262 (1998)
- Bonhomme A, "Quantitative immunolocalization of a P29 protein (GRA7), a new antigen of Toxoplasma gondii", J Histochem Cytochem, 46, pp.1411~1422 (1998)
- Neudeck A, "Expression variance, biochemical and immunological properties of Toxoplasma gondii dense granule protein GRA7", Microbes Infect, 4, pp.581~590 (2002)
- Pickering BM, "Bag- 1 internal ribosome entry segment activity is promoted by structural changes mediated by poly (rC) binding protein 1 and recruitment of polypyrimidine tract binding protein 1", Mol Cell Biol, 24, pp.5595~5605 (2004)
- Leffers H, "Characterization of two major cellular poly (rC)-binding human proteins, each containing three K-homologous (KH) domains", Eur J Biochem, 230, pp.447~453 (1995)
- Kiledjian M, "dentification of two KH domain proteins in the alpha-globin mRNP stability complex", EMBO J, 14, pp.4357~4364 (1995)
- Carey KL, "Identification and molecular characterization of GRA8, a novel, proline-rich, dense granule protein of Toxoplasma gondii", Mol Biochem Parasitol, 105, pp.25~37 (2000)
- Adjogble KD, "GRA9, a new Toxoplasma gondii dense granule protein associated with the intravacuolar network of tubular membranes", Int J Parasitol, 34, pp.1255~1264 (2004)
- Wurster AL, "Interleukin- 4-mediated protection of primary B cells from apoptosis through Stat6-dependent up-regulation of Bcl-xL", J Biol Chem, 277, pp.27169~27175 (2002)
- Blanchard C, "Eotaxin-3", CCL26 gene expression in intestinal epithelial cells is up-regulated by interleukin-4 and interleukin-13 via the signal transducer and activator of transcription 6, 2005, pp.37, 2559~2573
- Comai L, "Reconstruction of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits", Science, 266, pp.1966~1972 (1994)
- 안혜진, "Nucleolar translocalization of GRA10 of Toxoplasma gondii transfectionally expressed in HeLa cells", The Korean Journal of Parasitology, 45(3), pp.165~174 (2007), 대한기생충학회
- Coutavas E, "Characterization of proteins that interact with the cell-cycle regulatory protein Ran", TC4, 1993, pp.366, 585~587
- Seewald MJ, "Biochemical characterization of the Ran-RanBP1-Ran- GAP system: are RanBP proteins and the acidic tail of RanGAP required for the Ran-RanGAP GTPase reaction?", Mol Cell Biol, 23, pp.8124~8136 (2003)
- Steggerda SM, "The mammalian MogI protein is a guanine nucleotide release factor for Ran", J Biol Chem, 275, pp.23175~23180 (2000)
