Recent progress in vaccine development targeting pre-clinical human toxoplasmosis
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Toxoplasma gondii is an intracellular parasitic organism affecting all warm-blooded vertebrates. Due to the unavailability of commercialized human T. gondii vaccine, many studies have been reported investigating the protective efficacy of pre-clinical T. gondii vaccines expressing diverse antigens. Careful antigen selection and implementing multifarious immunization strategies could enhance protection against toxoplasmosis in animal models. Although none of the available vaccines could remove the tissue-dwelling parasites from the host organism, findings from these pre-clinical toxoplasmosis vaccine studies highlighted their developmental potential and provided insights into rational vaccine design. We herein explored the progress of T. gondii vaccine development using DNA, protein subunit, and virus-like particle vaccine platforms. Specifically, we summarized the findings from the pre-clinical toxoplasmosis vaccine studies involving T. gondii challenge infection in mice published in the past 5 years.
Abstract
Toxoplasma gondii is an intracellular parasitic organism affecting all warm-blooded vertebrates. Due to the unavailability of commercialized human T. gondii vaccine, many studies have been reported investigating the protective efficacy of pre-clinical T. gondii vaccines expressing diverse antigens. Careful antigen selection and implementing multifarious immunization strategies could enhance protection against toxoplasmosis in animal models. Although none of the available vaccines could remove the tissue-dwelling parasites from the host organism, findings from these pre-clinical toxoplasmosis vaccine studies highlighted their developmental potential and provided insights into rational vaccine design. We herein explored the progress of T. gondii vaccine development using DNA, protein subunit, and virus-like particle vaccine platforms. Specifically, we summarized the findings from the pre-clinical toxoplasmosis vaccine studies involving T. gondii challenge infection in mice published in the past 5 years.
참고문헌 (47)
- Montoya JG, "Toxoplasmosis", Lancet, 363(9425), pp.1965~1976 (2004)[DOI]
- Robert-Gangneux F, "Epidemiology of and diagnostic strategies for toxoplasmosis", Clin Microbiol Rev, 25(2), pp.264~296 (2012)[DOI]
- Jones JL, "Congenital toxoplasmosis : a review", Obstet Gynecol Surv, 56(5), pp.296~305 (2001)[DOI]
- Wang JL, "Advances in the development of anti-Toxoplasma gondii vaccines : challenges, opportunities, and perspectives", Trends Parasitol, 35(3), pp.239~253 (2019)[DOI]
- Silva LA, "Genetic polymorphisms and phenotypic profiles of sulfadiazine-resistant and sensitive Toxoplasma gondii isolates obtained from newborns with congenital Toxoplasmosis in Minas Gerais, Brazil", PLoS One, 12(1), pp.e0170689~ (2017)[DOI]
- Aspinall TV, "The molecular basis of sulfonamide resistance in Toxoplasma gondii and implications for the clinical management of toxoplasmosis", J Infect Dis, 185(11), pp.1637~1643 (2002)[DOI]
- Silva LA, "Efficacy of sulfadiazine and pyrimetamine for treatment of experimental toxoplasmosis with strains obtained from human cases of congenital disease in Brazil", Exp Parasitol, 202, pp.7~14 (2019)[DOI]
- Dubey JP, "Toxoplasmosis in sheep--the last 20 years", Vet Parasitol, 163(1-2), pp.1~14 (2009)[DOI]
- Innes EA, "A one health approach to vaccines against Toxoplasma gondii", Food Waterborne Parasitol, 15, pp.e00053~ (2019)[DOI]
- Havelaar AH, "World Health Organization global estimates and regional comparisons of the burden of foodborne disease in 2010", PLoS Med, 12(12), pp.e1001923~ (2015)[DOI]
- Pollard AJ, "A guide to vaccinology : from basic principles to new developments", Nat Rev Immunol, 21(2), pp.83~100 (2021)[DOI]
- Cyster JG, "B cell responses : cell interaction dynamics and decisions", Cell, 177(3), pp.524~540 (2019)[DOI]
- Tang DC, "Genetic immunization is a simple method for eliciting an immune response", Nature, 356(6365), pp.152~154 (1992)[DOI]
- Li L, "Molecular mechanisms for enhanced DNA vaccine immunogenicity", Expert Rev Vaccines, 15(3), pp.313~329 (2016)[DOI]
- Cui Z, "DNA vaccine", Adv Genet, 54, pp.257~289 (2005)[DOI]
- Würtele H, "Illegitimate DNA integration in mammalian cells", Gene Ther, 10(21), pp.1791~1799 (2003)[DOI]
- Faurez F, "Biosafety of DNA vaccines : new generation of DNA vectors and current knowledge on the fate of plasmids after injection", Vaccine, 28(23), pp.3888~3895 (2010)[DOI]
- Lee J, "Engineering DNA vaccines against infectious diseases", Acta Biomater, 80, pp.31~47 (2018)[DOI]
- Zhu Y, "Immunization with a DNA vaccine encoding the Toxoplasma gondii’s GRA39 prolongs survival and reduce brain cyst formation in a murine model", Front Microbiol, 12, pp.630682~ (2021)[DOI]
- Zheng B, "GRA24-based DNA vaccine prolongs survival in mice challenged with a virulent Toxoplasma gondii strain", Front Immunol, 10, pp.418~ (2019)[DOI]
- Zheng B, "The virulencerelated MYR1 protein of Toxoplasma gondii as a novel DNA vaccine against toxoplasmosis in mice", Front Microbiol, 10, pp.734~ (2019)[DOI]
- Sun HC, "Enhancing immune responses to a DNA vaccine encoding Toxoplasma gondii GRA7 using calcium phosphate nanoparticles as an adjuvant", Front Cell Infect Microbiol, 11, pp.787635~ (2021)[DOI]
- Zhu YC, "Protective immunity induced by TgMIC5 and TgMIC16 DNA vaccines against toxoplasmosis", Front Cell Infect Microbiol, 11, pp.686004~ (2021)[DOI]
- Zhang D, "Vaccination with recombinant adenoviruses expressing Toxoplasma gondii MIC3, ROP9, and SAG2 provide protective immunity against acute toxoplasmosis in mice", Vaccine, 37(8), pp.1118~1125 (2019)[DOI]
- Zepp F, "Principles of vaccine design-Lessons from nature", Vaccine, 28(suppl), pp.C14~C24 (2010)[DOI]
- Rosano GL, "Recombinant protein expression in Escherichia coli : advances and challenges", Front Microbiol, 5, pp.172~ (2014)[DOI]
- Ducker C, "Comparative analysis of protein expression systems and PTM landscape in the study of transcription factor ELK-1", Protein Expr Purif, 203, pp.106216~ (2022)[DOI]
- D’Amico C, "Development of vaccine formulations : past, present, and future", Drug Deliv Transl Res, 11(2), pp.353~372 (2021)[DOI]
- Zhao G, "Immunization with Toxoplasma gondii aspartic protease 3 increases survival time of infected mice", Acta Trop, 171, pp.17~23 (2017)[DOI]
- Fereig RM, "Immunization with Toxoplasma gondii peroxiredoxin 1induces protective immunity against toxoplasmosis in mice", PLoS One, 12(4), pp.e0176324~ (2017)[DOI]
- Liu F, "Protective effect against toxoplasmosis in BALB", c mice vaccinated with recombinant Toxoplasma gondii MIF, CDPK3, and 14-3-3 protein cocktail vaccine, 2021, pp.12, 755792~
- Chu KB, "Virus-like particle vaccines against respiratory viruses and protozoan parasites", Curr Top Microbiol Immunol, 433, pp.77~106 (2021)[DOI]
- Bachmann MF, "The influence of antigen organization on B cell responsiveness", Science, 262(5138), pp.1448~1451 (1993)[DOI]
- Brune KD, "New routes and opportunities for modular construction of particulate vaccines : stick, click, and glue", Front Immunol, 9, pp.1432~ (2018)[DOI]
- Manolova V, "Nanoparticles target distinct dendritic cell populations according to their size", Eur J Immunol, 38(5), pp.1404~1413 (2008)[DOI]
- Bachmann MF, "Vaccine delivery : a matter of size, geometry, kinetics and molecular patterns", Nat Rev Immunol, 10(11), pp.787~796 (2010)[DOI]
- Lee SH, "Protection induced by virus-like particles containing Toxoplasma gondii microneme protein 8 against highly virulent RH strain of Toxoplasma gondii infection", PLoS One, 12(4), pp.e0175644~ (2017)[DOI]
- 강해지, "Virus-like Particle Vaccine Containing Toxoplasma gondii Rhoptry Protein 13 Induces Protection against T. gondii ME49 Infection in Mice", Parasites, Hosts and Diseases, 57(5), pp.543~547 (2019), 대한기생충학ㆍ열대의학회[DOI]
- 강해지, "Virus-Like Particles Expressing Toxoplasma gondii Rhoptry Protein 18 Induces Better Protection Than Rhoptry Protein 4 against T. gondii Infection", Parasites, Hosts and Diseases, 56(5), pp.429~435 (2018), 대한기생충학ㆍ열대의학회
- Kang HJ, "Toxoplasma gondii virus-like particle vaccination alleviates inflammatory response in the brain upon T. gondii infection", Parasite Immunol, 42(6), pp.e12716~ (2020)[DOI]
- Kang HJ, "Influenza virus-like particles presenting both Toxoplasma gondii ROP4and ROP13 enhance protection against T. gondii infection", Pharmaceutics, 11(7), pp.342~ (2019)[DOI]
- Lee SH, "Virus-like particle vaccines expressing Toxoplasma gondii rhoptry protein 18 and microneme protein 8 provide enhanced protection", Vaccine, 36(38), pp.5692~5700 (2018)[DOI]
- Lee SH, "Protective immunity induced by incorporating multiple antigenic proteins of Toxoplasma gondii into influenza virus-like particles", Front Immunol, 9, pp.3073~ (2018)[DOI]
- Lee SH, "Virus-like particles containing multiple antigenic proteins of Toxoplasma gondii induce memory T cell and B cell responses", PLoS One, 14(8), pp.e0220865~ (2019)[DOI]
- Guo J, "Immunogenicity of a virus-like-particle vaccine containing multiple antigenic epitopes of Toxoplasma gondii against acute and chronic toxoplasmosis in mice", Front Immunol, 10, pp.592~ (2019)[DOI]
- Kang HJ, "Protective immunity induced by CpG ODN-adjuvanted virus-like particles containing Toxoplasma gondii proteins", Parasite Immunol, 43(1), pp.e12799~ (2021)[DOI]
- Kang HJ, "Evaluation of CpG-ODN-Adjuvanted Toxoplasma gondii virus-like particle vaccine upon one, two, and three immunizations", Pharmaceutics, 12(10), pp.989~ (2020)[DOI]
