Interpretation and Use of Natriuretic Peptides in Non-Congestive Heart Failure Settings
2
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
Natriuretic peptides (NPs) have been found to be useful markers in differentiating acute dyspneic patients presenting to the emergency department (ED) and emerged as potent prognostic markers for patients with congestive heart failure (CHF). The best-established and widely used clinical application of BNP and NT-proBNP testing is for the emergent diagnosis of CHF in patients presenting with acute dyspnea. Nevertheless, elevated NPs levels can be found in many circumstances involving left ventricular (LV) dysfunction or hypertrophy; right ventricular (RV) dysfunction secondary to pulmonary diseases; cardiac inflammatory or infectious diseases;endocrinology diseases and high output status without decreased LV ejection fraction. Even in the absence of significant clinical evidence of volume overload or LV dysfunction, markedly elevated NP levels can be found in patients with multiple comorbidities with a certain degree of prognostic value. Potential clinical applications of NPs are expanded accompanied by emerging reports regarding screening the presence of secondary cardiac dysfunction;monitoring the therapeutic responses, risk stratifications and providing prognostic values in many settings. Clinicians need to have expanded knowledge regarding the interpretation of elevated NPs levels and potential clinical applications of NPs. Clinicians should recognize that currently the only reasonable application for routine practice is limited to differentiation of acute dyspnea, rule-out-diagnostic-tests, monitoring of therapeutic responses and prognosis of acute or decompensated CHF. The rationales as well the potential applications of NPs in these settings are discussed in this review article.
Abstract
Natriuretic peptides (NPs) have been found to be useful markers in differentiating acute dyspneic patients presenting to the emergency department (ED) and emerged as potent prognostic markers for patients with congestive heart failure (CHF). The best-established and widely used clinical application of BNP and NT-proBNP testing is for the emergent diagnosis of CHF in patients presenting with acute dyspnea. Nevertheless, elevated NPs levels can be found in many circumstances involving left ventricular (LV) dysfunction or hypertrophy; right ventricular (RV) dysfunction secondary to pulmonary diseases; cardiac inflammatory or infectious diseases;endocrinology diseases and high output status without decreased LV ejection fraction. Even in the absence of significant clinical evidence of volume overload or LV dysfunction, markedly elevated NP levels can be found in patients with multiple comorbidities with a certain degree of prognostic value. Potential clinical applications of NPs are expanded accompanied by emerging reports regarding screening the presence of secondary cardiac dysfunction;monitoring the therapeutic responses, risk stratifications and providing prognostic values in many settings. Clinicians need to have expanded knowledge regarding the interpretation of elevated NPs levels and potential clinical applications of NPs. Clinicians should recognize that currently the only reasonable application for routine practice is limited to differentiation of acute dyspnea, rule-out-diagnostic-tests, monitoring of therapeutic responses and prognosis of acute or decompensated CHF. The rationales as well the potential applications of NPs in these settings are discussed in this review article.
참고문헌 (112)
- Swedberg K, "Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005): The Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology", Eur Heart J, 26, pp.1115~1140 (2005)
- Januzzi JL, "NT-proBNP testing for diagnosis and short-term prognosis in acute destabilized heart failure: an international pooled analysis of 1256 patients: the International Collaborative of NT-proBNP Study", Eur Heart J, 27, pp.330~337 (2006)
- Kisch B, "Electron microscopy of the atrium of the heart", I. Guinea pig. Exp Med Surg, 14, pp.99~112 (1956)
- De Bold AJ, "Heart atria granularity effects of changes in waterelectrolyte balance", Proc Soc Exp Biol Med, 161, pp.508~511 (1979)
- Iwanaga Y, "B-type natriuretic peptide strongly reflects diastolic wall stress in patients with chronic heart failure: comparison between systolic and diastolic heart failure", J Am Coll Cardiol, 47, pp.742~748 (2006)
- Burjonroppa SC, "Cancer patients with markedly elevated B-type natriuretic peptide may not have volume overload", Am J Clin Oncol, 30, pp.287~293 (2007)
- Schrier RW, "Hormones and hemodynamics in heart failure", N Engl J Med, 341, pp.577~585 (1999)
- Young JB, "Testing for B-type natriuretic peptide in the diagnosis and assessment of heart failure: what are the nuances?", Cleve Clin J Med, 71, pp.S1~17 (2004)
- Hawkridge AM, "Quantitative mass spectral evidence for the absence of circulating brain natriuretic peptide (BNP-32) in severe human heart failure", Proc Natl Acad Sci U S A, 102, pp.17442~17447 (2005)
- Omland T, "Advances in congestive heart failure management in the intensive care unit: B-type natriuretic peptides in evaluation of acute heart failure", Crit Care Med, 36, pp.S17~27 (2008)
- Prontera C, "Proficiency testing project for brain natriuretic peptide (BNP) and the N-terminal part of the propeptide of BNP (NT-proBNP) immunoassays: the CardioOrmocheck study" (2009), Clin Chem Lab Med 2009
- Chen AA, "NT-proBNP levels, echocardiographic findings, and outcomes in breathless patients: results from the ProBNP Investigation of Dyspnoea in the Emergency Department (PRIDE) echocardiographic substudy", Eur Heart J, 27, pp.839~845 (2006)
- Vanderheyden M, "Head to head comparison of N-terminal pro-B-type natriuretic peptide and B-type natriuretic peptide in patients with", without left ventricular systolic dysfunction, 2006, pp.39, 640~645
- Brown A, "Could BNP screening of acute chest pain cases lead to safe earlier discharge of patients with non-cardiac causes? A pilot study", QJM, 100, pp.755~761 (2007)
- Fukuta H, "Anemia is an independent predictor for elevated plasma levels of natriuretic peptides in patients undergoing cardiac catheterization for coronary artery disease", Circ J, 72, pp.212~217 (2008)
- Ogawa A, "Difference in elevation of N-terminal pro-BNP and conventional cardiac markers between patients with ST elevation vs non-ST elevation acute coronary syndrome", Circ J, 70, pp.1372~1378 (2006)
- Sinclair H, "Predicting outcome in patients with acute coronary syndrome: evaluation of B-type natriuretic peptide and the global registry of acute coronary events (GRACE) risk score", Scott Med J, 52, pp.8~13 (2007)
- Günes Y, "Value of brain natriuretic peptide after acute myocardial infarction", Anadolu Kardiyol Derg, 8, pp.182~187 (2008)
- Kwan G, "Short-term serial sampling of natriuretic peptides in patients presenting with chest pain", J Am Coll Cardiol, 49, pp.1186~1192 (2007)
- Palazzuoli A, "Osteoprotegerin and B-type natriuretic peptide in non-ST elevation acute coronary syndromes: relation to coronary artery narrowing and plaques number", Clin Chim Acta, 391, pp.74~79 (2008)
- Sun T, "Prognostic value of B-type natriuretic peptide in patients with acute coronary syndromes", Arch Med Res, 37, pp.502~505 (2006)
- Fonarow GC, "Usefulness of B-Type natriuretic peptide and cardiac troponin levels to predict in-hospital mortality from ADHERE", Am J Cardiol, 101, pp.231~237 (2008)
- Tello-Montoliu A, "A multimarker risk stratification approach to non-ST elevation acute coronary syndrome: implications of troponin T, CRP, NT pro-BNP and fibrin D-dimer levels", J Intern Med, 262, pp.651~658 (2007)
- Morrow DA, "Prognostic value of serial B-type natriuretic peptide testing during follow-up of patients with unstable coronary artery disease", JAMA, 294, pp.2866~2871 (2005)
- Yildirir A, "Value of peri-procedural B-type natriuretic peptide levels in predicting cardiac events after elective percutaneous coronary intervention", Acta Cardiol, 63, pp.47~52 (2008)
- Lo Mauro R, "B-type natriuretic peptide as a marker of asymptomatic re-stenosis after coronary implantation of a paclitaxeleluting stent", J Cardiovasc Med (Hagerstown), 8, pp.1020~1023 (2007)
- Elíasdóttir SB, "Brain natriuretic peptide is a good predictor for outcome in cardiac surgery", Acta Anaesthesiol Scand, 52, pp.182~187 (2008)
- Turk T, "Plasma brain natriuretic peptide after isolated on-pump coronary artery bypass grafting: prediction of postoperative adverse outcomes", Heart Surg Forum, 11, pp.E84~89 (2008)
- Sarzi Braga S, "Plasma B-type natriuretic peptide predicts atrial fibrillation during rehabilitation after cardiac surgery", Eur J Cardiovasc Prev Rehabil, 15, pp.460~466 (2008)
- Shaw SM, "Does brain natriuretic peptide interact with the immune system after cardiac transplantation?", Transplantation, 84, pp.1377~1381 (2007)
- Rossano JW, "B-type Natriuretic peptide is a sensitive screening test for acute rejection in pediatric heart transplant patients", J Heart Lung Transplant, 27, pp.649~654 (2008)
- Martínez-Dolz L, "Prognostic relationship between two serial determinations of B-type natriuretic peptide and mediumlong-term events in heart transplantation", J Heart Lung Transplant, 27, pp.735~740 (2008)
- Heise G, "Biomarker responses during mid-term mechanical cardiac support in children", J Heart Lung Transplant, 27, pp.150~157 (2008)
- Pruszczyk P, "N-terminal pro-brain natriuretic peptide as an indicator of right ventricular dysfunction", J Card Fail, 11, pp.S65~69 (2005)
- Alonso-Martínez JL, "Nterminal pro-B-type natriuretic peptide predicts the burden of pulmonary embolism", Am J Med Sci, 337, pp.88~92 (2009)
- Yardan T, "B-type natriuretic peptide as an indicator of right ventricular dysfunction in acute pulmonary embolism", Int J Clin Pract, 62, pp.1177~1182 (2008)
- Binder L, "N-terminal pro-brain natriuretic peptide or troponin testing followed by echocardiography for risk stratification of acute pulmonary embolism", Circulation, 112, pp.1573~1579 (2005)
- Enea I, "Biohumoral markers and right ventricular dysfunction in acute pulmonary embolism: the answer to thrombolytic therapy", Ital Heart J Suppl, 5, pp.29~35 (2004)
- Logeart D, "Biomarker-based strategy for screening right ventricular dysfunction in patients with non-massive pulmonary embolism", Intensive Care Med, 33, pp.286~292 (2007)
- Yap LB, "Natriuretic peptides, respiratory disease, and the right heart", Chest, 126, pp.1330~1336 (2004)
- Yano S, "The study of pulmonary hypertension and plasma BNP values in respiratory diseases", Nihon Kokyuki Gakkai Zasshi, 44, pp.99~103 (2006)
- Andreassen AK, "N-terminal pro-B-type natriuretic peptide as an indicator of disease severity in a heterogeneous group of patients with chronic precapillary pulmonary hypertension", Am J Cardiol, 98, pp.525~529 (2006)
- Yap LB, "Natriuretic peptides, respiratory disease, and the right heart", Chest, 126, pp.1330~1336 (2004)
- Kanat F, "Diuretics, plasma brain natriuretic peptide and chronic obstructive pulmonary disease", Neth J Med, 65, pp.296~300 (2007)
- Stolz D, "Use of B-type natriuretic peptide in the risk stratification of acute exacerbations of COPD", Chest, 133, pp.1088~1094 (2008)
- Chien JY, "Changes in B-type natriuretic peptide improve weaning outcome predicted by spontaneous breathing trial", Crit Care Med, 36, pp.1421~1426 (2008)
- Moe GW, "Canadian Multicenter Improved Management of Patients With Congestive Heart Failure (IMPROVE-CHF) Study Investigators. N-terminal pro-B-type natriuretic peptide testing improves the management of patients with suspected acute heart failure: primary results of the Canadian prospective randomized multicenter IMPROVE-CHF study", Circulation, 115, pp.3103~3110 (2007)
- Iltumur K, "N-terminal proBNP plasma levels correlate with severity of mitral stenosis", J Heart Valve Dis, 14, pp.735~741 (2005)
- Arat-Ozkan A, "Serum N-terminal pro-BNP levels correlate with symptoms and echocardiographic findings in patients with mitral stenosis", Echocardiography, 22, pp.473~478 (2005)
- Cemri M, "Relationship between N-terminal pro-B type natriuretic peptide and extensive echocardiographic parameters in mild to moderate aortic stenosis", J Postgrad Med, 54, pp.12~16 (2008)
- Della Corte A, "Preoperative, postoperative and 1-year follow-up N-terminal pro-B-type natriuretic peptide levels in severe chronic aortic regurgitation: correlations with echocardiographic findings", Interact Cardiovasc Thorac Surg, 7, pp.419~424 (2008)
- Moura LM, "New cardiovascular biomarkers:clinical implications in patients with valvular heart disease", Expert Rev Cardiovasc Ther, 6, pp.945~954 (2008)
- Iversen K, "Heart murmur and N-terminal pro-brain natriuretic peptide as predictors of death in 2977 consecutive hospitalized patients", Am J Med Sci, 335, pp.444~450 (2008)
- Therkelsen SK, "ANP and BNP in atrial fibrillation before and after cardioversion--and their relationship to cardiac volume and function", Int J Cardiol, 127, pp.396~399 (2008)
- Sacher F, "Chronic atrial fibrillation ablation impact on endocrine and mechanical cardiac functions", Eur Heart J, 29, pp.1290~1295 (2008)
- Tveit A, "Candesartan, NT-proBNP and recurrence of atrial fib-rillation after electrical cardioversion", Int J Cardiol, 131, pp.234~239 (2009)
- Yamada T, "Plasma brain natriuretic peptide level after hybrid therapy with pulmonary vein isolation and antiarrhythmic drugs for atrial fibrillation", Int Heart J, 49, pp.143~151 (2008)
- Ahlsson A, "Atrial function after epicardial microwave ablation in patients with atrial fibrillation", Scand Cardiovasc J, 42, pp.192~201 (2008)
- Magioncalda A, "The utility of assaying the N-terminal of brain natriuretic peptide precursor (NT pro-BNP) to predict the clinical outcome in patients with supraventricular tachyarrhythmias observed and treated in the emergency room", Recenti Prog Med, 99, pp.141~145 (2008)
- Kawanishi Y, "Effect of left ventricular dyssynchrony on plasma B-type natriuretic peptide levels in patients with long-term right ventricular apical pacing", Int Heart J, 49, pp.165~173 (2008)
- Koch A, "Plasma levels of B-type natriuretic peptide in children and adolescents with high degree atrioventricular block", Int J Cardiol, 134, pp.429~430 (2009)
- Ogawa T, "Angiotensin II receptor antagonism reverts the selective cardiac BNP upregulation and secretion observed in myocarditis", Am J Physiol Heart Circ Physiol, 294, pp.H2596~2603 (2008)
- Grabowski M, "Diagnostic value of BNP in suspected perimyocarditis--a preliminary report", Kardiol Pol, 61, pp.451~458 (2004)
- Kahveci G, "Prognostic value of N-terminal pro-B-type natriuretic peptide in patients with active infective endocarditis", Am J Cardiol, 99, pp.1429~1433 (2007)
- Bayram E, "The role of adrenomedullin and brain natriuretic peptide levels in acute rheumatic fever in adults", Anadolu Kardiyol Derg, 8, pp.188~191 (2008)
- Zhang QY, "Change in plasma Nterminal pro-brain natriuretic peptide in children with Kawasaki disease and its value in clinical practice", Zhonghua Er Ke Za Zhi, 44, pp.886~890 (2006)
- Leya FS, "The efficacy of brain natriuretic peptide levels in differentiating constrictive pericarditis from restrictive cardiomyopathy", J Am Coll Cardiol, 45, pp.1900~1902 (2005)
- Babuin L, "Brain natriuretic peptide levels in constrictive pericarditis and restrictive cardiomyopathy", J Am Coll Cardiol, 47, pp.1489~1491 (2006)
- Pfister R, "NTpro-BNP for differential diagnosis in patients with syncope", Int J Cardiol, 133, pp.51~54 (2009)
- Usui Y, "Plasma B-type natriuretic peptide level is associated with left ventricular hypertrophy among obstructive sleep apnoea patients", J Hypertens, 26, pp.117~123 (2008)
- Ybarra J, "Aminoterminal pro-brain natriuretic peptide (NT-proBNP) and sleep-disordered breathing in morbidly obese females: a cross-sectional study", Diab Vasc Dis Res, 5, pp.19~24 (2008)
- Seki S, "Clinical significance of B-type natriuretic Peptide in the assessment of untreated hypertension", Circ J, 72, pp.770~777 (2008)
- Sbarouni E, "D-dimer and BNP levels in acute aortic dissection", Int J Cardiol, 122, pp.170~172 (2007)
- Czernik C, "B-type natriuretic peptide to predict ductus intervention in infants < 28 weeks", Pediatr Res, 64, pp.286~290 (2008)
- Farombi-Oghuvbu I, "N-terminal pro-B-type natriuretic peptide: a measure of significant patent ductus arteriosus", Arch Dis Child Fetal Neonatal Ed, 93, pp.F257~260 (2008)
- Palladini G, "Serum N-terminal pro-brain natriuretic peptide is a sensitive marker of myocardial dysfunction in AL amyloidosis", Circulation, 107, pp.2440~2445 (2003)
- Nikolaou NI, "Brain natriuretic peptide increases in septic patients without severe sepsis or shock", Eur J Intern Med, 18, pp.535~541 (2007)
- Nakamura T, "Polymyxin Bimmobilized fiber hemoperfusion attenuates increased plasma atrial natriuretic peptide and brain natriuretic Peptide levels in patients with septic shock", ASAIO J, 54, pp.210~213 (2008)
- Christ-Crain M, "Use of B-type natriuretic peptide in the risk stratification of community-acquired pneumonia", J Intern Med, 264, pp.166~176 (2008)
- Kandil E, "B-type natriuretic peptide: a biomarker for the diagnosis and risk stratification of patients with septic shock", Arch Surg, 143, pp.242~246 (2008)
- Varpula M, "Predictive value of N-terminal probrain natriuretic peptide in severe sepsis and septic shock", Crit Care Med, 35, pp.1277~1283 (2007)
- Naganuma T, "The prognostic role of brain natriuretic peptides in hemodialysis patients", Am J Nephrol, 22, pp.437~444 (2002)
- Goei D, "Influence of renal function on the usefulness of N-terminal pro-B-type natriuretic peptide as a prognostic cardiac risk marker in patients undergoing noncardiac vascular surgery", Am J Cardiol, 101, pp.122~126 (2008)
- Tagore R, "Natriuretic peptides in chronic kidney disease", Clin J Am Soc Nephrol, 3, pp.1644~1651 (2008)
- Biasioli S, "Significance of plasma B-type natriuretic peptide in hemodialysis patients: blood sample timing and comorbidity burden", ASAIO J, 53, pp.587~591 (2007)
- Winkler K, "Change in N-terminal-pro-B-type-natriuretic-peptide and the risk of sudden death, stroke, myocardial infarction, and all-cause mortality in diabetic dialysis patients", Eur Heart J (2008)
- Yildiz R, "Brain natriuretic peptide and severity of disease in nonalcoholic cirrhotic patients", J Gastroenterol Hepatol, 20, pp.1115~1120 (2005)
- Henriksen JH, "Increased circulating pro-brain natriuretic peptide (proBNP) and brain natriuretic peptide (BNP) in patients with cirrhosis: relation to cardiovascular dysfunction and severity of disease", Gut, 52, pp.1511~1517 (2003)
- Januzzi JL, "Natriuretic peptide testing for the evaluation of critically ill patients with shock in the intensive care unit: a prospective cohort study", Crit Care, 10, pp.R37~ (2006)
- Levitt JE, "Diagnostic utility of B-type natriuretic peptide in critically ill patients with pulmonary edema: a prospective cohort study", Crit Care, 12, pp.R3~ (2008)
- Kia M, "The efficacy of B-type natriuretic peptide for early identification of blood loss in traumatic injury", Am J Surg, 191, pp.353~357 (2006)
- Tobian AA, "N-terminal pro-brain natriuretic peptide is a useful diagnostic marker for transfusion-associated circulatory overload", Transfusion, 48, pp.1143~1150 (2008)
- Meyer B, "N-terminal pro-B-type natriuretic peptide is an independent predictor of outcome in an unselected cohort of critically ill patients", Crit Care Med, 35, pp.2268~2273 (2007)
- Schultz M, "N-terminal-pro-B-type natriuretic peptide (NT-pro-BNP) in different thyroid function states", Clin Endocrinol (Oxf), 60, pp.54~59 (2004)
- Wei T, "B-type natriuretic peptide in patients with clinical hyperthyroidism", J Endocrinol Invest, 28, pp.8~11 (2005)
- Ozmen B, "Serum Nterminal-pro-B-type natriuretic peptide (NT-pro-BNP) levels in hyperthyroidism and hypothyroidism", Endocr Res, 32, pp.1~8 (2007)
- Anne M, "Neurohormonal activation in ischemic stroke: effects of acute phase disturbances on long-term mortality", Curr Neurovasc Res, 4, pp.170~175 (2007)
- Giannakoulas G, "N-terminal pro-brain natriuretic peptide levels are elevated in patients with acute ischemic stroke", Angiology, 56, pp.723~730 (2005)
- Nakagawa K, "Plasma concentrations of brain natriuretic peptide in patients with acute ischemic stroke", Cerebrovasc Dis, 19, pp.157~164 (2005)
- Di Angelantonio E, "Determinants of plasma levels of brain natriuretic peptide after acute ischemic stroke or TIA", J Neurol Sci, 260, pp.139~142 (2007)
- Montaner J, "Etiologic diagnosis of ischemic stroke subtypes with plasma biomarkers", Stroke, 39, pp.2280~2287 (2008)
- Anne M, "Neurohormonal activation in ischemic stroke: effects of acute phase disturbances on long-term mortality", Curr Neurovasc Res, 4, pp.170~175 (2007)
- Berendes E, "Secretion of brain natriuretic peptide in patients with aneurysmal subarachnoid haemorrhage", Lancet, 349, pp.245~249 (1997)
- Lu DC, "Cerebral salt wasting and elevated brain natriuretic peptide levels after traumatic brain injury: 2 case reports", Surg Neurol, 69, pp.226~229 (2008)
- Stewart D, "B-type natriuretic peptide levels may be elevated in the critically injured trauma patient without congestive heart failure", J Trauma, 63, pp.747~750 (2007)
- Tung PP, "Plasma B-type natriuretic peptide levels are associated with early cardiac dysfunction after subarachnoid hemorrhage", Stroke, 36, pp.1567~1569 (2005)
- Espiner EA, "The neuro-cardio-endocrine response to acute subarachnoid haemorrhage", Clin Endocrinol (Oxf), 56, pp.629~635 (2002)
- Kirchhoff C, "Intrathecal and systemic concentration of NT-proBNP in patients with severe traumatic brain injury", J Neurotrauma, 23, pp.943~949 (2006)
- Yarlagadda S, "Cardiovascular predictors of in-patient mortality after subarachnoid hemorrhage", Neurocrit Care, 5, pp.102~107 (2006)
- Rauchenzauner M, "Brain-type natriuretic peptide secretion following febrile and afebrile seizures - a new marker in childhood epilepsy?", Epilepsia, 48, pp.101~106 (2007)
- Obi T, "Secretion of natriuretic peptides caused by an epileptic attack", Acta Neurol Scand, 106, pp.225~228 (2002)
- Davutoglu V, "Serum levels of NT-ProBNP as an early cardiac marker of carbon monoxide poisoning", Inhal Toxicol, 18, pp.155~158 (2006)
