Persistence and Degradation Pattern of Acequinocyl and Its Metabolite, Hydroxyl-Acequinocyl and Fenpyroximate in Butterburs (Petasites japonicus Max.)
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Persistence and degradation patterns of acequinocyl and its metabolite, hydroxyl-acequinocyl (acequinocyl-OH) and fenpyroximate in butterburs (Petasites japonicus Max.) were investigated after pesticide application. Butterburs, one of the minor crops in South Korea, was planted in two plots (plot A for double and plot B for single application) in a greenhouse. Butterburs samples were also planted in a separate plot without pesticide treatment, as the control. A commercial pesticide containing acequinocyl and fenpyroximate was applied to the foliage of butterburs at hourly intervals after dilution. Recoveries of acequinocyl and acequinocyl-OH were 78.6-84.7% and 83.7-95.5%, respectively; the relative standard deviation of the two compounds were less than 5%. The method limit of quantification was 0.01 mg/kg. The total (Ʃ) acequinocyl residues in butterburs reduced by 96.0% at 14 days and 75.9% at 7 days, in plot A and B, respectively, after final pesticide applications. The biological half-life (DT50) of Ʃ acequinocyl and fenpyroximate, calculated using the dissipation rate, was 3.0 days and 4.0 days, respectively. These data were used to set up maximum residue and safe standard levels when the pesticides are applied to control pests during butterbur cultivation. Risk assessment results showed that the maximum % acceptable daily intake was 7.74% for Ʃ acequinocyl and 0.16% for Ʃ fenpyroximate. The theoretical maximum daily intake of Ʃ acequinocyl and fenpyroximate was 26.3% and 35.8%, respectively. In conclusion, the concentrations of Ʃ acequinocyl and fenpyroximate in butterburs pose no significant health risks to Koreans.
Abstract
Persistence and degradation patterns of acequinocyl and its metabolite, hydroxyl-acequinocyl (acequinocyl-OH) and fenpyroximate in butterburs (Petasites japonicus Max.) were investigated after pesticide application. Butterburs, one of the minor crops in South Korea, was planted in two plots (plot A for double and plot B for single application) in a greenhouse. Butterburs samples were also planted in a separate plot without pesticide treatment, as the control. A commercial pesticide containing acequinocyl and fenpyroximate was applied to the foliage of butterburs at hourly intervals after dilution. Recoveries of acequinocyl and acequinocyl-OH were 78.6-84.7% and 83.7-95.5%, respectively; the relative standard deviation of the two compounds were less than 5%. The method limit of quantification was 0.01 mg/kg. The total (Ʃ) acequinocyl residues in butterburs reduced by 96.0% at 14 days and 75.9% at 7 days, in plot A and B, respectively, after final pesticide applications. The biological half-life (DT50) of Ʃ acequinocyl and fenpyroximate, calculated using the dissipation rate, was 3.0 days and 4.0 days, respectively. These data were used to set up maximum residue and safe standard levels when the pesticides are applied to control pests during butterbur cultivation. Risk assessment results showed that the maximum % acceptable daily intake was 7.74% for Ʃ acequinocyl and 0.16% for Ʃ fenpyroximate. The theoretical maximum daily intake of Ʃ acequinocyl and fenpyroximate was 26.3% and 35.8%, respectively. In conclusion, the concentrations of Ʃ acequinocyl and fenpyroximate in butterburs pose no significant health risks to Koreans.
참고문헌 (27)
- OECD, "OECD Guidance Document on Defining Minor Uses of Pesticides", ~ (2014)
- Lee J, "Dissipation of the insecticide cyantraniliprole and its metabolite IN-J9Z38 in proso millet during cultivation", Scientific Reports, 9(1), pp.11648~ (2019)[DOI]
- Lamichhane JR, "Challenges and opportunities for integrated pest management in Europe : A telling example of minor uses", Crop Protection, 74, pp.42~47 (2015)[DOI]
- 이미경, "농약의 마이너 사용에 대한 국내외 관리 및 규제 현황", 농약과학회지, 17(3), pp.231~236 (2013), 한국농약과학회[DOI]
- Lee JS, "Chemical constituents of the leaves of butterbur(Petasites japonicus)and their anti-inflammatory effects", Biomolecules, 9(12), pp.806~ (2019)[DOI]
- Matsuura H, "Isolation and measurement of quercetin glucosides in flower buds of Japanese butterbur(Petasites japonicus subsp. gigantea Kitam. )", Bioscience, Biotechnology, and Biochemistry, 66(7), pp.1571~1575 (2002)[DOI]
- 서훈석, "머위(Petasites japonicus) 추출물의 항산화와 항암활성 효과", 한국자원식물학회지, 21(4), pp.265~269 (2008), 한국자원식물학회
- USDA FAS, "Implementation of Positive List System for Maximum Residue Limits", ~ (2018)
- Suh E, "Evaluation of resistance pattern to fenpyroximate and pyridaben in Tetranychus urticae collectedfrom greenhouses and apple orchards using lethal concentration-slope relationship", Experimental & Applied Acarology, 38, pp.151~165 (2006)[DOI]
- Yorulmaz Salman S, "Acequinocyl resistance in Tetranychus urticae Koch(Acari : Tetranychidae) : inheritance, synergists, cross-resistance and biochemical resistance mechanisms", International Journal of Acarology, 40(6), pp.428~435 (2014)[DOI]
- Marcic D, "Acaricides in modern management of plant-feeding mites", Journal of Pest Science, 85(4), pp.395~408 (2012)[DOI]
- 박천호, "Butterbur (Petasites japonicus Max.) Extract Improves Lipid Profiles and Antioxidant Activities in Monosodium l-Glutamate-Challenged Mice", Journal of Medicinal Food, 13(5), pp.1216~1223 (2010), 한국식품영양과학회
- Malhat F, "Residues, half-life times, dissipation, and safety evaluation of the acaricide fenpyroximate applied on grapes", Toxicological & Environmental Chemistry, 95(8), pp.1309~1317 (2013)[DOI]
- Caboni P, "Determination of acequinocyl and hydroxyacequinocyl on fruits and vegetables by HPLC-DAD", Journal of Agricultural and Food Chemistry, 52(22), pp.6700~6702 (2004)[DOI]
- European Food Safety Authority(EFSA), "Modification of the existing maximum residue level for acequinocyl in gherkins", EFSA Journal, 14(8), pp.e04568~ (2016)[DOI]
- Tae Woong Na, "Residual Pattern of Acequinocyl and Hydroxyacequinocyl in Perilla Leaf Grown under Greenhouse Conditions using Ultra Performance Liquid Chromatography-Photo Diode Array Detector with Tandem Mass Confirmation", Applied Biological Chemistry, 55(5), pp.657~662 (2012), 한국응용생명화학회
- Hwang KW, "Dissipation and removal of the etofenprox residue during processing in spring onion", Journal of Agricultural and Food Chemistry, 63(30), pp.6675~6680 (2015)[DOI]
- Chun OK, "Estimation of risks of pesticide exposure, by food intake, to Koreans", Food and Chemical Toxicology, 41(8), pp.1063~1076 (2003)[DOI]
- National food & nutrition statistics I: Based on 2014 Korea national health and nutrition examination survey; 20 September 2020, "Korea Health Industry Development Institute(KHIDI)", ~ (2016)
- Kim YA, "Method development, matrix effect, and risk assessment of 49multiclass pesticides in kiwifruit using liquid chromatography coupled to tandem mass spectrometry", Journal of Chromatography B, 1076, pp.130~138 (2018)[DOI]
- Malhat F, "Residue, dissipation, and dietary intake evaluation of fenpyroximate acaricide in", on guava, orange, and eggplant under open field condition, 2022, pp.9, 939012~
- Farha W, "An overview on common aspects influencing the dissipation pattern of pesticides : A review", Environmental Monitoring Assessment, 188, pp.693~ (2016)[DOI]
- Lewis K, "Development of a data set of pesticide dissipation rates in", on various plant matrices for the pesticide properties database(PPDB), 2017, pp.2(3), 28~
- Dekeyser MA, "Acaricide mode of action", Pest Management Science, 61(2), pp.103~110 (2005)[DOI]
- European Food Safety Authority(EFSA), "Conclusion on the peer review of the pesticide risk assessment of the active substance fenpyroximate", EFSA Journal, 11(12), pp.3493~ (2013)[DOI]
- Fenoll J, "Dissipation rates of insecticides and fungicides in peppers grown in greenhouse and under cold storage conditions", Food Chemistry, 113(2), pp.727~732 (2009)[DOI]
- Noh HH, "Dissipation, persistence, and risk assessment of fluxapyroxad and penthiopyrad residues in perilla leaf (Perilla frutescens var. japonica Hara)", PLoS One, 14(4), pp.e0212209~ (2019)[DOI]