지역사회 성인에서 대사증후군과 우울증의 관련성
Association between Metabolic Syndrome and Depression in Community-dwelling Adults
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초록
연구배경 : 대사증후군과 우울증과의 관련성에 대한 역학연구들에서 상반된 결과들이 보고되고 있다. 본 연구에서는 지역사회 성인을 대상으로 대사증후군과 우울증과의 관련성에 대해서 알아보았다. 방 법 : 본 연구는 2007년 및 2008년 4-6월에 광주광역시 동구에서 단면조사 연구로 수행된 지역사회 건강조사에 참여한 50-90세 성인 4,090명 (남성 1,502명, 여성 2,588명)을 대상으로 하였다. 대사증후군의 정의는 개정된 National Cholesterol Education Program Adult Treatment Panel Ⅲ 기준을 따랐으며, 우울증은 Center for Epidemiologic Studies Depression Scale (CES-D) 을 이용하여 판정하였다. 로지스틱 회귀분석을 시행하여 대사증후군과 우울증 (CES-D ≥21) 과의 관련성을 분석하였다. 결 과 : 대사증후군 유병률은 남성이 35.7%, 여성이 52.1%였다. 나이, 체질량지수, 흡연, 음주, 운동, 교육 수준, 결혼 상태, 건강보장 종류를 보정한 로지스틱 회귀분석 결과, 대사증후군과 우울증과의 관련성은 남성 (odds ratio(OR)=1.23, 95% confidence interval(CI)=0.65-2.33) 과 여성 (OR=0.99, 95% CI=0.75-1.31) 에서 모두 유의하지 않았다. 결 론 : 본 지역사회 기반 단면연구에서 대사증후군과 우울증은 관련성이 없었다. 대사증후군이 우울증에 미치는 영향을 확인하기 위해서는 지역사회 기반의 전향적인 연구가 필요할 것이다.
Abstract
Background : Epidemiologic studies of the relationship between metabolic syndrome (MetS) and depression have reported conflicting results. We investigated whether MetS is associated with depression in community-dwelling older adults. Methods : Data for this population-based cross-sectional study were collected from 4,090 subjects (1,502 men; 2,588 women) aged 50-90 years who completed the Community Health Survey in Dong-gu, Gwangju metropolitan city between April 2007 and June 2008. MetS was defined according to the modified National Cholesterol Education Program Adult Treatment Panel Ⅲ criteria, and depression was assessed using the Center for Epidemiologic Studies Depression Scale (CES-D). The relationship between MetS and depression (CES-D ≥21) was assessed by logistic regression analysis. Results : The prevalence of MetS was 35.7% in men and 52.1% in women. After controlling for age, body mass index, smoking status, alcohol consumption, physical activity, level of education, marital status, and health security system, MetS was not associated with depression in both men (odds ratio, OR=1.23, 95% confidence interval, CI=0.65-2.33) and women (OR=0.99, 95% CI=0.75-1.31). Conclusions : This community-based cross-sectional study found no clear association between MetS and depression. Further community-based prospective studies are needed to help establish the effects of MetS on depression.
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