대사증후군의 각 요소들과 우울증과의 상관성
Correlation Between Metabolic Syndrome and Depression according to BDI (Beck's Depression Inventory)
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초록
연구배경 : 대사증후군과 우울증은 심혈관 질환의 중요 위험인자임에도 불구하고 이 둘의 상관성에 대한 국내 연구는 아직 부족하다. 본 연구에서는 대사증후군의 각 요소들과 우울증과의 상관성에 대하여 알아보고자 한다. 방 법 : 2004년 6월부터 2005년 6월까지 서울의 일개 대학병원의 건강검진 수검자 중 449명을 대상으로 우울증에 대한 설문을 하였다. 대사증후군의 정의는 국제당뇨협회에서 제정한 것을 이용하였으며, 우울증은 Beck의 우울 척도(Beck Depression Inventory, BDI)로 평가하였다. 결 과 : 성별에 따라 체질량지수, 허리둘레, 수축기 혈압, 이완기 혈압, 중성지방, 공복혈당, 고밀도콜레스테롤, 대사증후군 유병률에 차이가 있었다. 또 가계 수입이 적은 군에 비해 많은 군이 우울증에 이환 될 교차비(odds ratio)가 0.567 (95% Confidence interval(CI): 0.347-0.927), 0.419 (95% CI: 0.226-0.778)로 유의한 차이를 보이며, 수입이 많아짐에 따라 우울의 비율이 유의하게 낮아졌다 (p for trend=0.0003). 그리고, 체질량지수는 우울증과 역의 상관관계를 보였으며 (p=0.0120), 또 BDI 점수는 남자에서 저 고밀도콜레스테롤혈증과 역의 상관관계를 보였고 (p=0.0236), 여자에서는 저 고밀도콜레스테롤혈증과 순의 상관관계를 보였다. (p=0.0313). 그러나 대사증후군과 그 외의 각 요소들은 우울증과 통계학적 유의성을 보이지 않았다. 결 론 : 우울증은 체질량지수가 높을수록 낮았다. 그리고, 대사증후군의 각 요소 중, 여자에서 고밀도콜레스테롤이 낮을수록 우울증이 높았으며, 남자에서는 오히려 고밀도콜레스테롤이 높을수록 우울증이 높았다. 대사증후군과 그 외 요소들과 우울증과는 관련성이 없었다.
Abstract
Background : Several studies have revealed a relationship between the metabolic syndrome and depression. But the relationship has not been studied yet in Korea. We studied whether metabolic syndrome and its components are associated with depression according to Beck's Depression Inventory(BDI). Methods : We examined 449 subjects who visited one college hospital in Seoul for medical check-up. The metabolic syndrome was defined according to the criteria of the International Diabetes Federation (IDF). We used the Korean version of Beck's Depression Inventory to check the depression. Results : Low HDL cholesterolemia was positively associated with depression in female (P<0.05), but negatively in men (P<0.05). Metabolic syndrome and other metabolic risk factors were not associated with depression. The body mass index was negatively correlated with depression. (P<0.05) Conclusions : Low HDL cholesterolemia was associated with depression. Otherwise, no clear association was found between the metabolic syndrome and depression.
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