Clinical Outcomes of Surgically Managed Spontaneous Tumors in 114 Client-owned Dogs
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Medical records of 139 tumors from 114 dogs that underwent surgery from May 2010 through March 2015 were retrospectively reviewed. Among 114 dogs, females (64.9%) were significantly more common than males (35.1%) (p＜0.05). Dogs aged 6 to 10 years were more presented than non-tumor patients, however, there was no significant difference. The mean age (±SD) was 10.3±3.0 years. Although we found no significant difference of breed predisposition, the most common breed was Maltese (19.3%), followed by Shih-Tzu (14.0%), and Yorkshire terrier (13.2%). Proportional morbidity ratios (PMRs) of mammary gland, oral cavity, and skin tumors were high in Poodles, Yorkshire terriers, and Golden retrievers, respectively. Mammary gland (36.0%) was the most common site, followed by skin and soft tissues (12.2%), oral cavity (10.8%), and digestive organs (8.6%), but there was no significant difference. The objectives of surgery were curative surgery (86.2%), biopsy (4.9%), and palliative surgery (6.5%). In this study, 123 of 139 tumors had histopathological diagnoses. Adenocarcinoma was the most common type (n=24), followed by adenoma (n=17), soft tissue sarcoma (n=13), benign mixed tumor (n=5), and others (n=64). Recurrence or suspected metastasis was identified in 26 dogs. Median survival times of malignant mammary gland tumors, skin and subcutaneous tumors, and splenic tumors were 1,563.0±1,201.7, 469, and 128 days, respectively.
Abstract
Medical records of 139 tumors from 114 dogs that underwent surgery from May 2010 through March 2015 were retrospectively reviewed. Among 114 dogs, females (64.9%) were significantly more common than males (35.1%) (p＜0.05). Dogs aged 6 to 10 years were more presented than non-tumor patients, however, there was no significant difference. The mean age (±SD) was 10.3±3.0 years. Although we found no significant difference of breed predisposition, the most common breed was Maltese (19.3%), followed by Shih-Tzu (14.0%), and Yorkshire terrier (13.2%). Proportional morbidity ratios (PMRs) of mammary gland, oral cavity, and skin tumors were high in Poodles, Yorkshire terriers, and Golden retrievers, respectively. Mammary gland (36.0%) was the most common site, followed by skin and soft tissues (12.2%), oral cavity (10.8%), and digestive organs (8.6%), but there was no significant difference. The objectives of surgery were curative surgery (86.2%), biopsy (4.9%), and palliative surgery (6.5%). In this study, 123 of 139 tumors had histopathological diagnoses. Adenocarcinoma was the most common type (n=24), followed by adenoma (n=17), soft tissue sarcoma (n=13), benign mixed tumor (n=5), and others (n=64). Recurrence or suspected metastasis was identified in 26 dogs. Median survival times of malignant mammary gland tumors, skin and subcutaneous tumors, and splenic tumors were 1,563.0±1,201.7, 469, and 128 days, respectively.
참고문헌 (38)
- Jemal, A., "Global cancer statistics", CA Cancer J. Clin, 61, pp.69~90 (2011)
- Siegel, R., "Cancer statistics, 2014", CA Cancer J. Clin, 64, pp.9~29 (2014)
- Fleming, J. M., "Mortality in North American dogs from 1984 to 2004: An investigation into age-, size-, and breed-related causes of death", J. Vet. Intern. Med, 25, pp.187~198 (2011)
- Inoue, M., "A current life table and causes of death for insured dogs in Japan", Prev. Vet. Med, 120, pp.210~218 (2015)
- Misdorp, W., "Veterinary cancer epidemiology", Vet. Q, 18, pp.32~36 (1996)
- Bronden, L. B., "Veterinary cancer registries in companion animal cancer: a review", Vet. Comp. Oncol, 5, pp.133~144 (2007)
- MacVean, D. W., "Frequency of canine and feline tumors in a defined population", Vet. Pathol, 15, pp.700~715 (1978)
- Dobson, J. M., "Canine neoplasia in the UK: estimates of incidence rates from a population of insured dogs", J. Small Anim. Pract, 43, pp.240~246 (2002)
- Merlo, D. F., "Cancer incidence in pet dogs: Findings of the animal tumor registry of Genoa", Italy. J. Vet. Intern. Med, 22, pp.976~984 (2008)
- Vascellari, M., "Animal tumour registry of two provinces in northern Italy:Incidence of spontaneous tumours in dogs and cats", BMC Vet. Res, 5, pp.39~ (2009)
- Bronden, L. B., "Data from the danish veterinary cancer registry on the occurrence and distribution of neoplasms in dogs in Denmark", Vet. Rec, 166, pp.586~590 (2010)
- 김대용, "Retrospective study of canine cutaneous tumors in Korea", Journal of Veterinary Science, 8(3), pp.229~236 (2007), 대한수의학회
- 김영훈, "Retrospective Investigation of Canine Skin and Mammary Tumors in Korea", 한국임상수의학회지, 26(6), pp.556~562 (2009), 한국임상수의학회
- Dorn, C. R., "Survey of animal neoplasms in Alameda and Contra Costa Counties, California. II. Cancer morbidity in dogs and cats from Alameda County", J. Natl. Cancer Inst, 40, pp.307~331 (1968)
- International Classification of Diseases for Oncology (ICD-O), "Fritz, A.", World Health Organization, 1~242 (2013)
- Cohen, D., "Epidemiological analysis of the most prevalent sites and types of canine neoplasia observed in a veterinary hospital", Cancer Res, 34, pp.2859~2868 (1974)
- Mitchell, L., "Mammary tumors in dogs: survey of clinical and pathological characteristics", Can. Vet. J, 15, pp.131~138 (1974)
- Moe, L., "Population-based incidence of mammary tumours in some dog breeds", J. Reprod. Fertil. Suppl, 57, pp.439~443 (2001)
- Todorova, I., "Prevalence and etiology of the most common malignant tumours in dogs and cats", B. J. Vet. Med, 9, pp.85~98 (2006)
- Rivera, P., "Mammary tumor development in dogs is associated with BRCA1 and BRCA2", Cancer Res, 69, pp.8770~8774 (2009)
- Pires, I., "Regression of canine cutaneous histiocytoma: reduced proliferation or increased apoptosis?", Anticancer Res, 33, pp.1397~1400 (2013)
- Butler, M., "Withrow & MacEwen’s Small Animal Clinical Oncology", pp.68~82 (2013), Elsevier saunders
- Ettinger, S. N., "Principles of treatment for canine lymphoma", Clin. Tech. Small. Anim. Pract, 18, pp.92~97 (2003)
- Spodnick, G. J., "Prognosis for dogs with appendicular osteosarcoma treated by amputation alone: 162 cases (1978-1988)", J. Am. Vet. Med. Assoc, 200, pp.995~999 (1992)
- Kuntz, C. A., "Prognostic factors for surgical treatment of soft-tissue sarcomas in dogs: 75 cases (1986-1996)", J. Am. Vet. Med. Assoc, 211, pp.1147~1151 (1997)
- Spangler, W. L., "Pathologic factors affecting postsplenectomy survival in dogs", J. Vet. Intern. Med, 11, pp.166~171 (1997)
- Wood, C. A., "Prognosis for dogs with stage I or II splenic hemangiosarcoma treated by splenectomy alone: 32 cases (1991-1993)", J. Am. Anim. Hosp. Assoc, 34, pp.417~421 (1998)
- Jermyn, K., "BSAVA Manual of Canine and Feline Oncology", pp.44~59 (2011), BSAVA
- Moore, G., "Clinical and experimental observations of the occurrence and fate of tumor cells in the blood stream", Ann. Surg, 146, pp.580~587 (1957)
- Sugarbaker, P. H., "Overview of peritoneal carcinomatosis", Cancerologia, 3, pp.119~124 (2008)
- 박수연, "Influence of surgical manipulation and surgical modality on the molecular detection of circulating tumor cells from colorectal cancer", 대한외과학회지, 82(6), pp.356~364 (2012), 대한외과학회[DOI]
- Atkin, G., "Colorectal cancer metastasis: in the surgeon's hands?", Int. Semin. Surg. Oncol, 2, pp.5~ (2005)
- Romsdahl, M. M., "Experimental model for the study of tumor cells in the blood", Acta. Cytol, 9, pp.141~145 (1965)
- Nishizaki, T., "Surgical manipulation of VX2 carcinoma in the rabbit liver evokes enhancement of metastasis", J. Surg. Res, 49, pp.92~97 (1990)
- Abgral, R., "Prognostic evaluation of percentage variation of metabolic tumor burden calculated by dual-phase 18FDG PET-CT imaging in patients with head and neck cancer", Head & Neck, 55, pp.691~696 (2015)
- Morris, J. S., "Effect of ovariohysterectomy in bitches with mammary neoplasms", Vet. Rec, 142, pp.656~658 (1998)
- Yamagami, T., "Influence of ovariohysterectomy at the time of mastectomy on the prognosis for canine malignant mammary tumors", J. Small Anim. Pract, 37, pp.462~464 (1996)
- Sorenmo, K. U., "Effect of spaying and timing of spaying on survival of dogs with mammary carcinoma", J. Vet. Intern. Med, 14, pp.266~270 (2000)