A case of canine bilateral ovary granulosa cell tumor and mammary complex carcinoma
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An 11-year-old poodle bitch was presented for investigation of multicentric mammary masses. Abdominal sonography and radiography demonstrated abnormal enlargement of uterus and ovaries. Blood analysis revealed high progesterone concentration. The ovariohysterectomy and mastectomy were performed. Histopathologically, the mammary masses revealed complex carcinoma-tubulopapillary carcinoma with papillary pattern and tubule pattern. In the uterus, cystic endometrial hyperplasia was observed. Scattered inflammatory cells were observed in the endometrial stroma and mucinous material was protruded from endometrial surface. Also, in the ovaries, bilateral ovary granulosa cell tumor was detected. The bitch made a complete recovery following the ovariohysterectomy and mastectomy. This case was a very rare multiple tumor occurrence with bilateral ovary granulosa cell tumor and mammary complex carcinoma. High progesterone concentration was characterized clinically in the bitch.
Abstract
An 11-year-old poodle bitch was presented for investigation of multicentric mammary masses. Abdominal sonography and radiography demonstrated abnormal enlargement of uterus and ovaries. Blood analysis revealed high progesterone concentration. The ovariohysterectomy and mastectomy were performed. Histopathologically, the mammary masses revealed complex carcinoma-tubulopapillary carcinoma with papillary pattern and tubule pattern. In the uterus, cystic endometrial hyperplasia was observed. Scattered inflammatory cells were observed in the endometrial stroma and mucinous material was protruded from endometrial surface. Also, in the ovaries, bilateral ovary granulosa cell tumor was detected. The bitch made a complete recovery following the ovariohysterectomy and mastectomy. This case was a very rare multiple tumor occurrence with bilateral ovary granulosa cell tumor and mammary complex carcinoma. High progesterone concentration was characterized clinically in the bitch.
참고문헌 (24)
- Bodner K, "Estrogen and progesterone receptor expression in patients with uterine smooth muscle tumours", Fertil Steril, 81, pp.1062~1066 (2004)
- Chu P, "Matrix metalloproteinases (MMPs) in the endometrium of bitches", Reproduction, 123, pp.467~477 (2002)
- Cohen D, "Epidemiologic analysis of the most prevalent sites and types of canine neoplasia in a veterinary hospital", Cancer Res, 34, pp.2859~2868 (1974)
- Davidson AP, "Ovarian and estrous cycle abnormalities, In Textbook of veterinary internal medicine", pp.1649~1655, Elsevier Saunders
- Feldman EC, "Canine female reproduction, In Canine and feline endocrinology and reproduction", pp.399~480 (1987), WB Saunders
- Graves PE, "Adenylate cyclase in human ovarian cancers: sensitivity to gonadotrophins and nonhormonal activators", Am J Obstet Gynecol, 153, pp.877~882 (1985)
- 김옥진, "Development of Mammary tumor and Endometrial Hyperplasia in a Dog using Chemical Contraception", Laboratory Animal Research, 21(2), pp.176~178 (2005), 한국실험동물학회
- Klein MK, "Tumors of the female reproductive system, In Small animal clinical oncology", pp.445~454 (2001), W.B. Saunders
- Leitner M, "Lectin binding patterns in normal canine endometrium and in bitches with pyometra and cystic endometrial hyperplasia", Histol Histopathol, 18, pp.787~795 (2002)
- Martín De Las Mulas J, "Oestrogen and progesterone receptors in feline fibroadenomatous change: an immunohistochemical study", Res Vet Sci, 68, pp.15~22 (2000)
- McCandlish IA, "Hormone producing ovarian tumours in the dog", Vet Rec, 105, pp.9~11 (1979)
- McEntee K, "Ovarian neoplasms, In Reproductive pathology of domestic mammals", pp.69~93 (1990), Academic Press
- McLachlan NJ, "Ovarian disorders in domestic animals", Environ Health Perspect, 73, pp.27~33 (1987)
- MacLachlan NJ, "Tumors of the genital system, In Tumors in domestic animals", pp.547~573 (2002), Iowa State Press
- Millán Y, "Steroid receptors in canine and human female genital tract tumours with smooth muscle differentiation", J Comp Pathol, 136, pp.197~201 (2007)
- Misdorp W, "Tumors of the mammary gland, In Tumors in domestic animals", pp.575~606 (2002), Iowa State Press
- Munson L, "Endometrial hyperplasia and mineralization in zoo felids treated with melengestrol acetate contraceptives", Vet Pathol, 39, pp.419~427 (2002)
- Pazol K, "Medroxyprogesterone acetate antagonizes the effects of estrogen treatment on social and sexual behavior in female Macaques", J Clin Endocrinol Metab, 89, pp.2998~3006 (2004)
- Patnaik AK, "Canine ovarian neoplasms: a clinicopathologic study of 71 cases including histology of 12 granulosa cell tumors", Vet Pathol, 24, pp.509~514 (1987)
- Purswell BJ, "Theriogenology question of the month. Persistent estrus caused by functional granulosa cell tumor of the left ovary", J Am Vet Med Assoc, 215, pp.193~195 (1999)
- Schafer KA, "A canine model of familial mammary gland neoplasia", Vet Pathol, 35, pp.168~177 (1998)
- Stouffer RL, "Investigation of binding sites for follicle-stimulating hormone and chorionic gonadotropin in human ovarian cancers", J Clin Endocrinol Metab, 59, pp.441~446 (1984)
- Vail DM, "ntaneously occurring tumors of companion animals as models for human cancer", Cancer Invest, 18, pp.781~792 (2000)
- Weikel JH Jr, "Problems in evaluating chronic toxicity of contraceptive steroids in dogs", J Toxicol Environ Health, 3, pp.167~177 (1977)