시추 개에서 발생한 T-cell 유래 림프육종 증례
Spontaneous canine T-cell lymphosarcoma in a Shih Tzu dog
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This study describes a canine lymphosarcoma with a rapid proliferation and recurrence. A 4-year-old, male, Shih Tzu dog was examined for acute swelling mass. The mass had been identified since 3 months ago and enlarged 10×7 cm and located in the right axillary region. The surgical removal was recommended when patient visited veterinarian and the operation was conducted. The removed tumor was 11×8×7 cm and firm, lobulated and white cut surface. Routine screening laboratory test was assessed with blood and radiological analysis. The metastasis sign was not detected on thoracic and abdominal radiography. Blood test revealed decreased lymphocytes. After surgical removal of the mass, microscopic histopathological examination was performed to determine the final diagnosis. Histopathologically, the tumors are characterized by the same histological features, including the presence of neoplastic cellular populations, and lymphocytes infiltration in varying proportions. Also, DNA was extracted and PCR analysis was employed to analyze the origin of tumor cells. T-cell specific nucleic acid fragments were specifically amplified by PCR. On the basis of the laboratory results, the tumor was diagnosed with canine T-cell lymphosarcoma. On the basis of our knowledge, this is the first report of canine T-cell lymphosarcoma in a Shih Tzu dog.
Abstract
This study describes a canine lymphosarcoma with a rapid proliferation and recurrence. A 4-year-old, male, Shih Tzu dog was examined for acute swelling mass. The mass had been identified since 3 months ago and enlarged 10×7 cm and located in the right axillary region. The surgical removal was recommended when patient visited veterinarian and the operation was conducted. The removed tumor was 11×8×7 cm and firm, lobulated and white cut surface. Routine screening laboratory test was assessed with blood and radiological analysis. The metastasis sign was not detected on thoracic and abdominal radiography. Blood test revealed decreased lymphocytes. After surgical removal of the mass, microscopic histopathological examination was performed to determine the final diagnosis. Histopathologically, the tumors are characterized by the same histological features, including the presence of neoplastic cellular populations, and lymphocytes infiltration in varying proportions. Also, DNA was extracted and PCR analysis was employed to analyze the origin of tumor cells. T-cell specific nucleic acid fragments were specifically amplified by PCR. On the basis of the laboratory results, the tumor was diagnosed with canine T-cell lymphosarcoma. On the basis of our knowledge, this is the first report of canine T-cell lymphosarcoma in a Shih Tzu dog.
참고문헌 (11)
- Ballegeer EA, "Correlation of ultrasonographic appearance of lesions and cytologic and histologic diagnoses in splenic aspirates of dogs and cats: 32 cases (2002-2005)", J Am Vet Med Assoc, 230, pp.690~696 (2007)
- Dickinson RM, "Canine lymphosarcoma: Overcoming diagnostic obstacles and introduction to the latest diagnostic techniques", Can Vet J, 49, pp.305~308 (2008)
- Jeon S, "Fast molecular diagnostics of canine T-cell lymphoma by PCR and capillary gel electrophoresis with laser-induced fluorescence detector", J Chromatogr B Analyt Technol Biomed Life Sci, 854, pp.268~272 (2007)
- Madewell BR, "Characterization of anemias associated with neoplasia in small animals", J Am Vet Med Assoc, 176, pp.419~425 (1980)
- MacEween EG, "Canine Lymphosarcoma and lymphoid leukemias, In Oncology. 2nd ed.", pp.451~478 (1996), WB Saunders
- Meuten DJ, "Hypercalcemia in dogs with lymphosarcoma. Biochemical, ultrastructural, and histomorphometric investigations", Lab Invest, 49, pp.553~562 (1983)
- Priester WA, "The occurrence of tumors in domestic animals", Natl Cancer Inst Monogr, 54, pp.1~210 (1980)
- Seacy GP, "Hemopoietic system, In Thomson's special veterinary pathology. 2nd ed.", pp.324~346 (1995), Mosby-Year Book Inc
- Vail DM, "Lymphoid Neoplasia, In Small animal practice. 1st ed.", pp.193~223 (1994), WB Saunders
- Weir EC, "Humoral hypercalcemia of malignancy in canine lymphosarcoma", Endocrinology, 122, pp.602~608 (1988)
- Withrow SJ, "Lymphoma, In Withrow and MacEwen’s Small animal clinical oncology. 4th ed", pp.699~733 (2007), Saunders Elsevier