한국인 자궁내막증 환자에서 p53 유전자 codon 72 다형성 양상
p53 Codon 72 Polymorphism in Patients with Endometriosis
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목적 : p53 다형성과 자궁내막증과의 연관성을 파악하고자 하였다. 연구 방법 : 복강경술 또는 개복술로 자궁내막증으로 진단된 환자 271명과 복강경술 또는 개복술에서 자궁내막증이 없는 것으로 확인된 대조군 219명을 대상으로 하여 p53 유전자 codon 72 다형성을 조사하였다. 결과 : p53 유전자 codon 72 다형성의 유전자형 분포는 자궁내막증 환자군과 대조군 사이에 유의한 차이는 없었다 (p=0.086). 반면 stage I-II인 경한 자궁내막증군에서 p53 유전자 codon 72 유전자형 분포는 대조군과 유의한 차이를 보였다 (p=0.043). 그러나 stage III-IV 자궁내막증군은 대조군과 p53 codon 72 유전자형의 분포에서 차이가 없었다. Pro/Pro 유전자형의 경우 Arg/Arg 유전자형과 비교시 stage I-II 자궁내막증 발생 위험도가 2.75로 유의하게 증가하였다. 결론 : 한국 여성에서 p53유전자의 codon 72 다형성은 경증의 자궁내막증 발생과 연관이 있었다.
Abstract
Objective : To explore the association of p53 codon 72 polymorphism with endometriosis. Methods : Two hundred seventy-one women with surgically or histologically diagnosed edometriosis of stage I-IV, and 219 patients with no evidence of endometriosis by laparoscopy or laparotomy served as control. Allele frequencies and genotype distribution of p53 polymorphisms (arginine homozygosity, heterozygosity, and proline homozygosity) in affected women and controls were evaluated. Results : The genotype distributions of p53 codon 72 polymorphisms did not differ significantly between endometriosis group and control group (p=0.086). However, the genotype distributions of p53 codon 72 polymorphisms differ significantly between stage I-II endometriosis group and control group (p=0.043). Proline homozygotes had higher risk for stage I-II endometriosis compared to arginine homozygotes (odds ratio=2.75, p=0.013). Conclusion : These results suggest that proline homozygote of p53 codon 72 polymorphism is associated with the risk of minimal or mild stage of endometriosis in the Korean population.
참고문헌 (23)
- "The genetic basis of endometriosis", 13, pp.309~314 (2001)
- "Microsatellite analysis of endometriosis reveals loss of heterozygosity at candidate ovarian tumor suppressor gene loci", 56, pp.3534~3539 (1996)
- "P53 codon 72 polymorphism and risk of cervical cancer in UK", 352, pp.871~875 (1998)
- "p53 codon 72 polymorphism and risk of cervical carcinoma in Korean women", 5, pp.65~67 (2000)
- "Polymorphism of TP53 codon 72 and the risk of cervical cancer among Korean women", 184, pp.55~58 (2001)
- "Prognostic significance of p53 codon 72 polymorphism in lung carcinomas", 35, pp.226~230 (1999)
- "Polymor phism of the p53 within the codon 72 in lung cancer patients", 48, pp.407~411 (2001)
- "p53 Gene polymorphism with susceptibility to esophageal cancer and lung cancer in Chinese population", 25, pp.365~367 (2003)
- "TP53 codon 72 polymorphism in oral squamous cell carcinoma", 22, pp.3379~3381 (2002)
- "The p53 codon 72 polymorphism and risk of oral cancer in Southern Thailand", 4, pp.209~214 (2003)
- "The p53 codon 72 polymorphism in Thia nasopharyngeal carcinoma", 198(1), pp.69~75 (2003)
- "A p53 codon 72 polymorphism associated with prostate cancer development and progression in Japanese", 10, pp.43~45 (2003)
- "p53 codon 72 polymorphism in breast cancer", 10, pp.711~714 (2003)
- "A p53 genetic polymorphism as a modulator of hepatocellular carcinoma risk in relation to chronic liver disease, familial tendency and cigarette smoking in hepatitis B carriers", pp.697~702 (1999)
- "The proline form of p53 codon 72 polymorphism is associated with endometriosis", 77, pp.43~45 (2002)
- "p53 codon 72 다형성과 한국인 여성의 자궁내막증의 연관성에 관한 연구", 29, pp.311~315 (2002)
- "Polymorphism at codon 72 of the p53 gene is not associated with endometriosis in a Japanese population", 11, pp.232~236 (2004)
- "Revised American Fertility Society classification of endometriosis:1985", 43, pp.351~352 (1985)
- "The relationship between laparoscopic disease, pelvic pain and infertility; an unbiased assessment", pp.57~62 (1997)
- "Interleukin-8 concentration in peritoneal fluid of patients with endometriosis and modulation of interleukin-8 expression in human mesothelial cells", 2, pp.40~45 (1996)
- "Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: implications for angiogenesis during the menstrual cycle and the pathogenesis of endometriosis", 81, pp.3112~3118 (1996)
- "Peritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities", 68, pp.585~596 (1997)
- "Possible involvement of arylamine N- acetyltransferase 2, glutathione S-transferases M1 and T1 genes in the development of endometriosis", 5, pp.636~641 (1999)