HPV E6 발암단백과 결합하는 CDC7 단백의 기능 분석

키워드

참고문헌 (28)

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7. "중지를 초래한다고 알려져 있다 세포에서도 CDC7의 murine homologs 의 불활성화는 DNA 합성을 중지시켜 세포의 성장을 중단시킨다는 연구결과가 보고된 바 있다 29 이는 DNA 합성에서 CDC7의 기능이 필수적이라는 것을 의미한다 muCdc7의 기능 상실은 recombinational repair와 G2", M checkpoint responses 및 p53의 활성을 유도하여 세포사멸을 초래한다 29 여러 종양세포주에서 siRNA 기법을 이용하여 CDC7을 불활성화 시키면 S기로의 진행 실패와 p53과는 독립적인 세포사멸 또는 aberrant mitosis에 의한 세포 사멸을 유발한다 반면 정상 fibroblast에서는 CDC7의 기능이 없으면 잘못된 S기를 통한 세포주기의 진행을 막기 위해 p53-dependent pathway가 작동하게 된다 30 본 실험에서 역시 HeLa 세포에 CDC7 siRNA를 통해 기능을 억제한 결과 E6가 억제되었을 때와, 28~
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19. "Direct activation of cyclin-dependent kinase 2 by human papillomavirus E7", 77, pp.10566~10574 (2003)
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28. "Cdc7 inhibition reveals a p53-dependent replication checkpoint that is defective in cancer cells", 64, pp.7110~7116 (2004)

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