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A CASE OF PEUTZ-JEGHERS SYNDROME WITH ENDOMETRIAL ADENOMYOMATOUS POLYP

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초록

Peutz-Jeghers syndrome, which has autosomal dominant inheritance, shows pigmentation in lip and skin. It also has features of harmatomatous polyp over the gastrointestinal tract, while sometimes developing tumor in genital tract. Known tumors in female genital tract include cervical adenocarcinoma, sex cord tumor, etc. Adenomyomatous polyp in uterus is also one of the rare diseases, which seldom develop in the absence of hormone treatment such as Tamoxifen. Currently, there is one case of Peutz-Jeghers syndrome patient with endometrial adenomyomatous polyp. Authors found mole-like lesions on the transvaginal ultrasonogram in a typical Peutz-Jeghers syndrome patient without pregnancy history and previous chemotherapy. After confi rming its diagnosis of adenomyomatous polyp on resectoscopic biopsy, we report our fi ndings along with brief literature review.

Abstract

Peutz-Jeghers syndrome, which has autosomal dominant inheritance, shows pigmentation in lip and skin. It also has features of harmatomatous polyp over the gastrointestinal tract, while sometimes developing tumor in genital tract. Known tumors in female genital tract include cervical adenocarcinoma, sex cord tumor, etc. Adenomyomatous polyp in uterus is also one of the rare diseases, which seldom develop in the absence of hormone treatment such as Tamoxifen. Currently, there is one case of Peutz-Jeghers syndrome patient with endometrial adenomyomatous polyp. Authors found mole-like lesions on the transvaginal ultrasonogram in a typical Peutz-Jeghers syndrome patient without pregnancy history and previous chemotherapy. After confi rming its diagnosis of adenomyomatous polyp on resectoscopic biopsy, we report our fi ndings along with brief literature review.

참고문헌 (10)

  1. Chen KT, "Female genital tract tumors in Peutz-Jeghers syndrome", Hum Pathol, 17, pp.858~861 (1986)
  2. Giardiello FM, "Very high risk of cancer in familial Peutz-Jeghers syndrome", Gastroenterology, 119, pp.1447~1453 (2000)
  3. Sato H, "Arias-Stella reaction in an adenomyomatous polyp of the uterus", Acta Obstet Gynecol Scand, 86, pp.106~108 (2007)
  4. Peterson WF, "Endometrial polyps", Obstet Gynecol, 8, pp.40~49 (1956)
  5. Nasu K, "Adenomyomatous polyp of the uterus", Int J Gynaecol Obstet, 48, pp.319~321 (1995)
  6. Takeuchi M, "A case of adenomyomatous polyp of the uterus associated with tamoxifen therapy", Radiat Med, 23, pp.432~434 (2005)
  7. De Brux J, "Histopathologie gyntcologique" (1971), Masson
  8. Silverberg SG, "Atlas of tumor pathology. 3rd ed" (1992), Armed Forces Institute of Pathology
  9. Furuhashi M, "Adenomyomatous polyp mimicking hydatidiform mole on ultrasonography", Arch Gynecol Obstet, 263, pp.198~200 (2000)
  10. Firminger HI, "Atlas of tumor pathology. Washington" (1968), Armed Forces Institute of Pathology

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