Congenital leukemia of fetus with acquired AML1 gene duplication
1
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Congenital leukemia is very rare, and its prevalence according to recently published papers is from 1 to 5 per million live births. This can be often diagnosed in postpartum throughout bone marrow biopsy, showing abnormal proliferation of immature blasts and granulocytic precursors. Hepatosplenomegaly is the most common feature which is found during perinatal examinations, that diagnosing is difficult during perinatal period. Hepatosplenomegaly can occur not only in congenital leukemia but in many other cases such as infection which is the most common cause. In other words, congenital leukemia is the one of the rare causes of hepatosplenomegaly. However, this case shows the fetus with the features of hepatosplenomegaly during perinatal period and being diagnosed as congenital leukemia associated with acquired AML1 gene duplication in postpartum through bone marrow biopsy. Due to its rare instance, we are to describe the case with a review of literatures.
Abstract
Congenital leukemia is very rare, and its prevalence according to recently published papers is from 1 to 5 per million live births. This can be often diagnosed in postpartum throughout bone marrow biopsy, showing abnormal proliferation of immature blasts and granulocytic precursors. Hepatosplenomegaly is the most common feature which is found during perinatal examinations, that diagnosing is difficult during perinatal period. Hepatosplenomegaly can occur not only in congenital leukemia but in many other cases such as infection which is the most common cause. In other words, congenital leukemia is the one of the rare causes of hepatosplenomegaly. However, this case shows the fetus with the features of hepatosplenomegaly during perinatal period and being diagnosed as congenital leukemia associated with acquired AML1 gene duplication in postpartum through bone marrow biopsy. Due to its rare instance, we are to describe the case with a review of literatures.
참고문헌 (15)
- Bader JL, "US cancer incidence and mortality in the first year of life", Am J Dis Child, 133, pp.157~159 (1979)
- Badhe PB, "Congenital leukemia: organ involvement in six autopsy cases", J Postgrad Med, 38, pp.127~129 (1992)
- Bargotra R, "Congenital leukemia", JK Sci, 12, pp.201~202 (2010)
- Prakash KP, "Congenital leukemia:a diagnostic dilemma", Indian J Med Paediatr Oncol, 29, pp.41~43 (2008)
- Bronshtein M, "Ultrasonography in obstetrics and gynecology", pp.615~623 (2008), Saunders Elsevier
- Vintzileos AM, "Fetal liver ultrasound measurements during normal pregnancy", Obstet Gynecol, 66, pp.477~480 (1985)
- Schmidt W, "Sonographic measurements of the fetal spleen: clinical implications", J Ultrasound Med, 4, pp.667~672 (1985)
- 최지훈, "A Case of Congenital Leukemia Cutis", Annals of Dermatology, 21(1), pp.66~70 (2009), 대한피부과학회
- Harewood L, "Amplification of AML1 on a duplicated chromosome 21 in acute lymphoblastic leukemia:a study of 20 cases", Leukemia, 17, pp.547~553 (2003)
- Sande JE, "Congenital and neonatal leukemia", Semin Perinatol, 23, pp.274~285 (1999)
- Nathan DG, "Hematology of infancy and childhood", pp.1052~1053 (1987), Saunders
- Van der Linden MH, "Diagnosis and management of neonatal leukaemia", Semin Fetal Neonatal Med, 17, pp.192~195 (2012)
- Bresters D, "Congenital leukaemia:the Dutch experience and review of the literature", Br J Haematol, 117, pp.513~524 (2002)
- Isaacs H Jr, "Fetal and neonatal leukemia", J Pediatr Hematol Oncol, 25, pp.348~361 (2003)
- Grundy RG, "Spontaneous remission of congenital leukemia: a case for conservative treatment", J Pediatr Hematol Oncol, 22, pp.252~255 (2000)