Acute Lymphoblastic Leukemia with Mature B-Cell Phenotype and t(9;11;11)(p22;q23;p11.2): A Case Study and Literature Review
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Patients with infantile ALL are fundamentally different from adult patients in that infants have a worse prognosis, which is attrib- uted to the increased relative incidence of MLL gene rearrange- ments [1, 2]. MLL is located on chromosome 11q23 and is a frequent target of chromosome translocations in hematopoietic malignancies. Patients with ALL and MLL rearrangements usu- ally have distinct characteristics, such as organomegaly, marked leukocytosis, and a high incidence of central nervous system leukemia [3, 4]. Most importantly, regardless of the age at pre- sentation, MLL rearrangement in ALL is associated with a poor response to therapy and a poor prognosis [5].
Abstract
Patients with infantile ALL are fundamentally different from adult patients in that infants have a worse prognosis, which is attrib- uted to the increased relative incidence of MLL gene rearrange- ments [1, 2]. MLL is located on chromosome 11q23 and is a frequent target of chromosome translocations in hematopoietic malignancies. Patients with ALL and MLL rearrangements usu- ally have distinct characteristics, such as organomegaly, marked leukocytosis, and a high incidence of central nervous system leukemia [3, 4]. Most importantly, regardless of the age at pre- sentation, MLL rearrangement in ALL is associated with a poor response to therapy and a poor prognosis [5].
참고문헌 (20)
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