Risk factors for cytological progression in HPV 16 infected women with ASC-US or LSIL: The Korean HPV cohor
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Objective This study was to identify the risk factors for cytological progression in women with atypical squamous cells ofundetermined significance (ASC-US) or low-grade squamous intraepithelial lesions (LSIL). Methods We analyzed data from women infected with the human papillomavirus (HPV) who participated in the Korean HPVcohort study. The cohort recruited women aged 20–60 years with abnormal cervical cytology (ASC-US or LSIL) fromApril 2010. All women were followed-up at every 6-month intervals with cervical cytology and HPV DNA testing. Results Of the 1,158 women included, 654 (56.5%) and 504 (43.5%) women showed ASC-US and LSIL, respectively. At thetime of enrollment, 143 women tested positive for HPV 16 (85 single and 58 multiple infections). Cervical cytologyperformed in the HPV 16-positive women showed progression in 27%, no change in 23%, and regression in 50% ofthe women at the six-month follow-up. The progression rate associated with HPV 16 infection was higher than thatwith infection caused by other HPV types (relative risk [RR], 1.75; 95% confidence interval [CI], 1.08–2.84; P =0.028). The cytological progression rate in women with persistent HPV 16 infection was higher than that in women withincidental or cleared infections (P <0.001). Logisticregression analysis showed a significant relationshipbetween cigarette smoking and cytological progression(RR, 4.15; 95% CI, 1.01–17.00). Conclusion The cytological progression rate in HPV 16-positivewomen with ASC-US or LSIL is higher than that in womeninfected with other HPV types. Additionally, cigarettesmoking may play a role in cytological progression.
Abstract
Objective This study was to identify the risk factors for cytological progression in women with atypical squamous cells ofundetermined significance (ASC-US) or low-grade squamous intraepithelial lesions (LSIL). Methods We analyzed data from women infected with the human papillomavirus (HPV) who participated in the Korean HPVcohort study. The cohort recruited women aged 20–60 years with abnormal cervical cytology (ASC-US or LSIL) fromApril 2010. All women were followed-up at every 6-month intervals with cervical cytology and HPV DNA testing. Results Of the 1,158 women included, 654 (56.5%) and 504 (43.5%) women showed ASC-US and LSIL, respectively. At thetime of enrollment, 143 women tested positive for HPV 16 (85 single and 58 multiple infections). Cervical cytologyperformed in the HPV 16-positive women showed progression in 27%, no change in 23%, and regression in 50% ofthe women at the six-month follow-up. The progression rate associated with HPV 16 infection was higher than thatwith infection caused by other HPV types (relative risk [RR], 1.75; 95% confidence interval [CI], 1.08–2.84; P =0.028). The cytological progression rate in women with persistent HPV 16 infection was higher than that in women withincidental or cleared infections (P <0.001). Logisticregression analysis showed a significant relationshipbetween cigarette smoking and cytological progression(RR, 4.15; 95% CI, 1.01–17.00). Conclusion The cytological progression rate in HPV 16-positivewomen with ASC-US or LSIL is higher than that in womeninfected with other HPV types. Additionally, cigarettesmoking may play a role in cytological progression.
참고문헌 (29)
- Torre LA, "Global cancer statistics, 2012", CA Cancer J Clin, 65, pp.87~108 (2015)
- 정규원, "Prediction of Cancer Incidence and Mortality in Korea, 2015", Cancer Research and Treatment, 47(2), pp.142~148 (2015), 대한암학회[DOI]
- 정규원, "Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2014", Cancer Research and Treatment, 49(2), pp.292~305 (2017), 대한암학회
- Walboomers JM, "Human papillomavirus is a necessary cause of invasive cervical cancer worldwide", J Pathol, 189, pp.12~19 (1999)
- 최윤진, "Clinical significance of human papillomavirus genotyping", Journal of Gynecologic Oncology, 27(2), pp.1~12 (2016), 대한부인종양학회
- 조현웅, "Type-specific persistence or regression of human papillomavirus genotypes in women with cervical intraepithelial neoplasia 1: A prospective cohort study", Obstetrics & Gynecology Science, 58(1), pp.40~45 (2015), 대한산부인과학회[DOI]
- Koshiol J, "Persistent human papillomavirus infection and cervical neoplasia: a systematic review and meta-analysis", Am J Epidemiol, 168, pp.123~137 (2008)
- Muñoz N, "Epidemiologic classification of human papillomavirus types associated with cervical cancer", N Engl J Med, 348, pp.518~527 (2003)
- Castellsagué X, "Natural history and epidemiology of HPV infection and cervical cancer", Gynecol Oncol, 110Suppl 2, pp.S4~S7 (2008)
- Khan MJ, "The elevated 10-year risk of cervical precancer and cancer in women with human papillomavirus (HPV) type 16 or 18 and the possible utility of typespecific HPV testing in clinical practice", J Natl Cancer Inst, 97, pp.1072~1079 (2005)
- Cox JT, "Prospective follow-up suggests similar risk of subsequent cervical intraepithelial neoplasia grade 2 or 3 among women with cervical intraepithelial neoplasia grade 1 or negative colposcopy and directed biopsy", Am J Obstet Gynecol, 188, pp.1406~1412 (2003)
- orius RG, "Burchette RJ. Subsequent risk and presentation of cervical intraepithelial neoplasia (CIN) 3 or cancer after a colposcopic diagnosis of CIN 1 or less", Am J Obstet Gynecol, 195, pp.1260~1265 (2006)
- Chen EY, "Histological ‘progression’ from low (LSIL) to high (HSIL) squamous intraepithelial lesion is an uncommon event and an indication for quality assurance review", Mod Pathol, 23, pp.1045~1051 (2010)
- 김주영, "Is human papillomavirus genotype an influencing factor on radiotherapy outcome? Ambiguity caused by an association of HPV 18 genotype and adenocarcinoma histology", Journal of Gynecologic Oncology, 22(1), pp.32~38 (2011), 대한부인종양학회
- 이원철, "Establishment of a Korea HPV cohort study", Journal of Gynecologic Oncology, 24(1), pp.59~65 (2013), 대한부인종양학회
- Smith JS, "Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions: a meta-analysis update", Int J Cancer, 121, pp.621~632 (2007)
- Saslow D, "American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer", Am J Clin Pathol, 137, pp.516~542 (2012)
- Wang SS, "Human papillomavirus cofactors by disease progression and human papillomavirus types in the study to understand cervical cancer early endpoints and determinants", Cancer Epidemiol Biomarkers Prev, 18, pp.113~120 (2009)
- Castellsagué X, "Chapter 3: cofactors in human papillomavirus carcinogenesis--role of parity, oral contraceptives, and tobacco smoking", J Natl Cancer Inst Monogr, 31, pp.20~28 (2003)
- IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, "Tobacco smoke and involuntary smoking", IARC Monogr Eval Carcinog Risks Hum, 83, pp.1~1438 (2004)
- Appleby P, "Carcinoma of the cervix and tobacco smoking: collaborative reanalysis of individual data on 13,541 women with carcinoma of the cervix and 23,017 women without carcinoma of the cervix from 23 epidemiological studies", Int J Cancer, 118, pp.1481~1495 (2006)
- Vaccarella S, "Smoking and human papillomavirus infection:pooled analysis of the International Agency for Research on Cancer HPV Prevalence Surveys", Int J Epidemiol, 37, pp.536~546 (2008)
- Poppe WA, "Tobacco smoking impairs the local immunosurveillance in the uterine cervix. An immunohistochemical study", Gynecol Obstet Invest, 39, pp.34~38 (1995)
- Poppe WA, "Cervical cotinine and macrophage-Langerhans cell density in the normal human uterine cervix", Gynecol Obstet Invest, 41, pp.253~259 (1996)
- Barton SE, "Effect of cigarette smoking on cervical epithelial immunity: a mechanism for neoplastic change?", Lancet, 2, pp.652~654 (1988)
- de Jong A, "Human papillomavirus type 16-positive cervical cancer is associated with impaired CD4+ T-cell immunity against early antigens E2and E6", Cancer Res, 64, pp.5449~5455 (2004)
- Evans EM, "Infiltration of cervical cancer tissue with human papillomavirus-specific cytotoxic T-lymphocytes", Cancer Res, 57, pp.2943~2950 (1997)
- Herrero R, "Invasive cervical cancer and smoking in Latin America", J Natl Cancer Inst, 81, pp.205~211 (1989)
- Schlecht NF, "Human papillomavirus infection and time to progression and regression of cervical intraepithelial neoplasia", J Natl Cancer Inst, 95, pp.1336~1343 (2003)