The Impact of High-Risk HPV Genotypes Other Than HPV 16/18 on the Natural Course of Abnormal Cervical Cytology: A Korean HPV Cohort Study
2
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
Purpose The purpose of this study is to evaluate the impact of high-risk human papillomaviruses (HPVs) other than HPV 16/18 on the natural course of atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesion (LSIL). Materials and Methods The study population was derived from the Korean HPV cohort (2010-2014). Women aged 20 to 60 who satisfied the criteria of having both HPV infection and abnormal cervical cytology of either ASC-US or LSIL were recruited from five institutions nationwide. Enrolled patients underwent cervical cytology and HPV DNA testing every 6 months. Results A total of 1,158 patients were enrolled. The 10 most common HPV types were HPV 16 (12.3%), 58 (10.0%), 56 (8.8%), 53 (8.4%), 52 (7.7%), 39 (6.2%), 18 (6.0%), 51 (5.7%), 68 (5.1%), and 66 (4.6%). Among these patients, 636 women were positive for high-risk HPVs other than HPV 16 or 18, and 429 women were followed for more than 6 months. Cytology evaluations showed progression in 15.3% of women, no change in 22.6%, and regression in 62.1% of women at 12 months. In cases of HPV 58 single infection, a more highly significant progression rate, compared to other high-risk types, was observed at 6 months (relative risk [RR], 3.3; 95% confidence interval [CI], 2.04 to 5.30; p < 0.001) and 12 months (RR, 5.03; 95% CI, 2.56 to 9.91; p < 0.001). Conclusion HPV genotypes numbered in the 50s were frequent in Korean women with ASC-US and LSIL. HPV 58 was the second most common type, with a high progression rate of cervical cytology.
Abstract
Purpose The purpose of this study is to evaluate the impact of high-risk human papillomaviruses (HPVs) other than HPV 16/18 on the natural course of atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesion (LSIL). Materials and Methods The study population was derived from the Korean HPV cohort (2010-2014). Women aged 20 to 60 who satisfied the criteria of having both HPV infection and abnormal cervical cytology of either ASC-US or LSIL were recruited from five institutions nationwide. Enrolled patients underwent cervical cytology and HPV DNA testing every 6 months. Results A total of 1,158 patients were enrolled. The 10 most common HPV types were HPV 16 (12.3%), 58 (10.0%), 56 (8.8%), 53 (8.4%), 52 (7.7%), 39 (6.2%), 18 (6.0%), 51 (5.7%), 68 (5.1%), and 66 (4.6%). Among these patients, 636 women were positive for high-risk HPVs other than HPV 16 or 18, and 429 women were followed for more than 6 months. Cytology evaluations showed progression in 15.3% of women, no change in 22.6%, and regression in 62.1% of women at 12 months. In cases of HPV 58 single infection, a more highly significant progression rate, compared to other high-risk types, was observed at 6 months (relative risk [RR], 3.3; 95% confidence interval [CI], 2.04 to 5.30; p < 0.001) and 12 months (RR, 5.03; 95% CI, 2.56 to 9.91; p < 0.001). Conclusion HPV genotypes numbered in the 50s were frequent in Korean women with ASC-US and LSIL. HPV 58 was the second most common type, with a high progression rate of cervical cytology.
참고문헌 (26)
- de Villiers EM, "Classification of papillomaviruses", Virology, 324, pp.17~27 (2004)
- Ferlay J, "Estimates of worldwide burden of cancer in 2008 : GLOBOCAN 2008", Int J Cancer, 127, pp.2893~2917 (2010)
- 정규원, "Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2012", Cancer Research and Treatment, 47(2), pp.127~141 (2015), 대한암학회[DOI]
- 정규원, "Prediction of Cancer Incidence and Mortality in Korea, 2015", Cancer Research and Treatment, 47(2), pp.142~148 (2015), 대한암학회[DOI]
- 설현주, "Epidemiologic characteristics of cervical cancer in Korean women", Journal of Gynecologic Oncology, 25(1), pp.70~74 (2014), 대한부인종양학회
- Smith JS, "Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions : a meta-analysis update", Int J Cancer, 121, pp.621~632 (2007)
- Saslow D, "American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer", CA Cancer J Clin, 62, pp.147~172 (2012)
- Munoz N, "Against which human papillomavirus types shall we vaccinate and screen? The international perspective", Int J Cancer, 111, pp.278~285 (2004)
- 이원철, "Establishment of a Korea HPV cohort study", Journal of Gynecologic Oncology, 24(1), pp.59~65 (2013), 대한부인종양학회
- Solomon D, "The 2001 Bethesda System : terminology for reporting results of cervical cytology", JAMA, 287, pp.2114~2119 (2002)
- Chan PK, "Association of human papillomavirus type 58 variant with the risk of cervical cancer", J Natl Cancer Inst, 94, pp.1249~1253 (2002)
- Hong D, "Distribution of human papillomavirus genotypes in the patients with cervical carcinoma and its precursors in Zhejiang Province, China", Int J Gynecol Cancer, 18, pp.104~109 (2008)
- Li Y, "Human papillomavirus type 58 genome variations and RNA expression in cervical lesions", J Virol, 87, pp.9313~9322 (2013)
- An HJ, "Correlation of cervical carcinoma and precancerous lesions with human papillomavirus (HPV) genotypes detected with the HPV DNA chip microarray method", Cancer, 97, pp.1672~1680 (2003)
- Chan PK, "Attribution of human papillomavirus types to cervical intraepithelial neoplasia and invasive cancers in Southern China", Int J Cancer, 131, pp.692~705 (2012)
- Ding DC, "Type-specific distribution of HPV along the full spectrum of cervical carcinogenesis in Taiwan : an indication of viral oncogenic potential", Eur J Obstet Gynecol Reprod Biol, 140, pp.245~251 (2008)
- Plummer M, "A 2-year prospective study of human papillomavirus persistence among women with a cytological diagnosis of atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesion", J Infect Dis, 195, pp.1582~1589 (2007)
- Rodriguez AC, "Rapid clearance of human papillomavirus and implications for clinical focus on persistent infections", J Natl Cancer Inst, 100, pp.513~517 (2008)
- Brown DR, "A longitudinal study of genital human papillomavirus infection in a cohort of closely followed adolescent women", J Infect Dis, 191, pp.182~192 (2005)
- Dalstein V, "Persistence and load of high-risk HPV are predictors for development of high-grade cervical lesions : a longitudinal French cohort study", Int J Cancer, 106, pp.396~403 (2003)
- Castle PE, "Short term persistence of human papillomavirus and risk of cervical precancer and cancer: population based cohort study", BMJ, 339, pp.2569~ (2009)
- Kjaer SK, "Long-term absolute risk of cervical intraepithelial neoplasia grade 3 or worse following human papillomavirus infection : role of persistence", J Natl Cancer Inst, 102, pp.1478~1488 (2010)
- Ting Deng, "Low initial human papillomavirus viral load may indicate worse prognosis in patients with cervical carcinoma treated with surgery", Journal of Gynecologic Oncology, 26(2), pp.111~117 (2015), 대한부인종양학회
- Chan PK, "Human papillomavirus type 58 : the unique role in cervical cancers in East Asia", Cell Biosci, 2, pp.17~ (2012)
- Chan PK, "Identification of human papillomavirus type 58 lineages and the distribution worldwide", J Infect Dis, 203, pp.1565~1573 (2011)
- Joura EA, "A 9-valent HPV vaccine against infection and intraepithelial neoplasia in women", N Engl J Med, 372, pp.711~723 (2015)