Effect of quercetin on the anti-tumor activity of cisplatin in EMT6 breast tumor-bearing mice
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ObjectiveThe purpose of this study was to determine the effect of quercetin on the antitumor activity of cisplatin and its sideeffects. MethodsEMT6 cells, a mouse breast cancer cell line, were injected subcutaneously in mice to generate a breast tumor-bearingmouse model. Experimental groups were divided into four groups: control (C), quercetin (Q), cisplatin (CP), andcisplatin+quercetin (CP+Q). ResultsThe tumor volume of the CP+Q group was significantly lower than that of the CP group. Serum blood urea nitrogenand creatinine levels in the CP+Q group were lower than those in the CP group. Renal γ-glutamyltranspeptidase andalkaline phosphatase activities were significantly higher in the CP+Q group than in the CP group, and the contentof renal thiobarbituric acid reactive substance was significantly lower in the CP+Q group than that in the CP group. These results suggested that quercetin and cisplatin synergistically increased cellular toxicity in breast cancer cellsand mediated cancer growth inhibition, thereby enhancing the antitumor effect of cisplatin compared to when onlycisplatin was administered. Quercetin also reduced renal toxicity, which arose as a potential a side effect of cisplatin. ConclusionThe enhanced antitumor effect of cisplatin and decreased renal toxicity after quercetin treatment suggested theapplicability of quercetin as an adjuvant for chemotherapeutic agents.
Abstract
ObjectiveThe purpose of this study was to determine the effect of quercetin on the antitumor activity of cisplatin and its sideeffects. MethodsEMT6 cells, a mouse breast cancer cell line, were injected subcutaneously in mice to generate a breast tumor-bearingmouse model. Experimental groups were divided into four groups: control (C), quercetin (Q), cisplatin (CP), andcisplatin+quercetin (CP+Q). ResultsThe tumor volume of the CP+Q group was significantly lower than that of the CP group. Serum blood urea nitrogenand creatinine levels in the CP+Q group were lower than those in the CP group. Renal γ-glutamyltranspeptidase andalkaline phosphatase activities were significantly higher in the CP+Q group than in the CP group, and the contentof renal thiobarbituric acid reactive substance was significantly lower in the CP+Q group than that in the CP group. These results suggested that quercetin and cisplatin synergistically increased cellular toxicity in breast cancer cellsand mediated cancer growth inhibition, thereby enhancing the antitumor effect of cisplatin compared to when onlycisplatin was administered. Quercetin also reduced renal toxicity, which arose as a potential a side effect of cisplatin. ConclusionThe enhanced antitumor effect of cisplatin and decreased renal toxicity after quercetin treatment suggested theapplicability of quercetin as an adjuvant for chemotherapeutic agents.
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