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Association of serum levels of vascular endothelial growth factor and thrombospondin-1 to body mass index in polycystic ovary syndrome: a case-control study

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PurposePolycystic ovary syndrome (PCOS) is a gynecological endocrine disorder that is characterized by disturbances in ovarianblood flow and angiogenesis. The aim of this study was to determine the association of vascular endothelial growthfactor (VEGF) and thrombospondin-1 (TSP-1) serum levels with the body mass index (BMI) in patients with PCOScompared with healthy subjects. MethodsThe study was conducted with 80 subjects in 3 PCOS groups, including normal weight, overweight, and obese PCOSgroups, and a control group of healthy subjects (n=20). The participants in all groups completed a questionnairecomprising sociodemographic and obstetric questions. The PCOS diagnosis in the study subjects was confirmed basedon the Rotterdam criteria, BMI was determined according to the World Health Organization guidelines, and the lipidaccumulation product index was calculated for all groups. Venous blood samples were collected from all participantsafter fasting to measure the serum levels of fasting blood glucose (FBG), lipids, insulin, VEGF, TSP-1, and leptin. ResultsOur findings showed that the serum VEGF level was significantly higher in the normal BMI PCOS group than thatin the control group (P=0.03), and the TSP-1 level was significantly lower in the obese PCOS group than that in thecontrol group (P=0.04). ConclusionsOur study demonstrated that alterations in VEGF and TSP-1 concentrations are dependent on BMI. Because abnormalovarian angiogenesis is considered to be the main feature of PCOS, the study of ovarian angiogenic imbalance isproposed as a new tool for PCOS diagnosis and management.

Abstract

PurposePolycystic ovary syndrome (PCOS) is a gynecological endocrine disorder that is characterized by disturbances in ovarianblood flow and angiogenesis. The aim of this study was to determine the association of vascular endothelial growthfactor (VEGF) and thrombospondin-1 (TSP-1) serum levels with the body mass index (BMI) in patients with PCOScompared with healthy subjects. MethodsThe study was conducted with 80 subjects in 3 PCOS groups, including normal weight, overweight, and obese PCOSgroups, and a control group of healthy subjects (n=20). The participants in all groups completed a questionnairecomprising sociodemographic and obstetric questions. The PCOS diagnosis in the study subjects was confirmed basedon the Rotterdam criteria, BMI was determined according to the World Health Organization guidelines, and the lipidaccumulation product index was calculated for all groups. Venous blood samples were collected from all participantsafter fasting to measure the serum levels of fasting blood glucose (FBG), lipids, insulin, VEGF, TSP-1, and leptin. ResultsOur findings showed that the serum VEGF level was significantly higher in the normal BMI PCOS group than thatin the control group (P=0.03), and the TSP-1 level was significantly lower in the obese PCOS group than that in thecontrol group (P=0.04). ConclusionsOur study demonstrated that alterations in VEGF and TSP-1 concentrations are dependent on BMI. Because abnormalovarian angiogenesis is considered to be the main feature of PCOS, the study of ovarian angiogenic imbalance isproposed as a new tool for PCOS diagnosis and management.

참고문헌 (33)

  1. Qu J, "The higher response of vascular endothelial growth factor and angiotensin-ii to human chorionic gonadotropin in women with polycystic ovary syndrome", Int J Fertil Steril, 8, pp.373~378 (2015)
  2. Peitsidis P, "Role of vascular endothelial growth factor in women with PCO and PCOS : a systematic review", Reprod Biomed Online, 20, pp.444~452 (2010)
  3. Diamanti-Kandarakis E, "Role of obesity and adiposity in polycystic ovary syndrome", Int J Obes, 31(Suppl 2), pp.S8~S13 (2007)
  4. Jin CH, "Body fat distribution and its associated factors in Korean women with polycystic ovary syndrome", J Obstet Gynaecol Res, 41, pp.1577~1583 (2015)
  5. El Hayek S, "Poly cystic ovarian syndrome : an updated overview", Front Physiol, 7, pp.124~ (2016)
  6. Wang R, "The Rotterdam criteria for polycystic ovary syndrome : evidence-based criteria", Hum Reprod, 32, pp.261~264 (2017)
  7. Bani Mohammad M, "Polycystic ovary syndrome(PCOS), diagnostic criteria, and AMH", Asian Pac J Cancer Prev, 18, pp.17~21 (2017)
  8. Osz K, "The thrombospondin-1 receptor CD36 is an important mediator of ovarian angiogenesis and folliculogenesis", Reprod Biol Endocrinol, 12, pp.21~ (2014)
  9. Geva E, "Role of vascular endothelial growth factor in ovarian physiology and pathology", Fertil Steril, 74, pp.429~438 (2000)
  10. Holmes DI, "The vascular endothelial growth factor(VEGF)family : angiogenic factors in health and disease", Genome Biol, 6, pp.209~ (2005)
  11. Greenaway J, "Vascular endothelial growth factor and its receptor, Flk-1", KDR, are cytoprotective in the extravascular compartment of the ovarian follicle, 2004, pp.145, 2896~2905
  12. Ferrara N, "The role of VEGF in the regulation of physiological and pathological angiogenesis", EXS, (94), pp.209~231 (2005)
  13. Loebig M, "Evidence for a relationship between VEGF and BMI independent of insulin sensitivity by glucose clamp procedure in a homogenous group healthy young men", PLoS One, 5, pp.e12610~ (2010)
  14. Lawler J, "Tumor progression : the effects of thrombospondin-1 and-2", Int J Biochem Cell Biol, 36, pp.1038~1045 (2004)
  15. Varma V, "Thrombospondin-1 is an adipokine associated with obesity, adipose inflammation, and insulin resistance", Diabetes, 57, pp.432~439 (2008)
  16. Tan BK, "Metformin decreases angiogenesis via NF-kappaB and Erk1", 2, Cardiovasc Res, pp.2009, 83[DOI]
  17. Maxel T, "Expression patterns and correlations with metabolic markers of zinc transporters ZIP14 and ZNT1 in obesity and polycystic ovary syndrome", Front Endocrinol(Lausanne), 8, pp.38~ (2017)
  18. Sanchez N, "A life course perspective on polycystic ovary syndrome", Int J Womens Health, 6, pp.115~122 (2014)
  19. F. BCJM, "Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome: Rotterdam ESHRE", ASRM-Sponsored 3rd PCOS Consensus Workshop Group, 2004, pp.81, 19~25
  20. Souza Dos Santos AC, "The impact of body mass on inflammatory markers and insulin resistance in polycystic ovary syndrome", Gynecol Endocrinol, 31, pp.225~228 (2015)
  21. Kahn HS, "The"lipid accumulation product"performs better than the body mass index for recognizing cardiovascular risk : a population-based comparison", BMC Cardiovasc Disord, 5, pp.26~ (2005)
  22. Wiltgen D, "Lipid accumulation product index : a reliable marker of cardiovascular risk in polycystic ovary syndrome", Hum Reprod, 24, pp.1726~1731 (2009)
  23. Duleba AJ, "Is PCOS an inflammatory process", Fertil Steril, 97, pp.7~12 (2012)
  24. Harada M, "Expression of vascular endothelial growth factor A during ligand-induced down-regulation of luteinizing hormone receptor in the ovary", Mol Cell Endocrinol, 328, pp.28~33 (2010)
  25. Bhattacharyya S, "Cell type-specific post-transcriptional regulation of production of the potent antiangiogenic and proatherogenic protein thrombospondin-1 by high glucose", J Biol Chem, 283, pp.5699~5707 (2008)
  26. Tada H, "High glucose levels enhance TGF-beta1-thrombospondin-1 pathway in cultured human mesangial cells via mechanisms dependent on glucose-induced PKC activation", J Diabetes Complications, 15, pp.193~197 (2001)
  27. Ebrahimi-Mamaghani M, "Association of insulin resistance with lipid profile, metabolic syndrome, and hormonal aberrations in overweight or obese women with polycystic ovary syndrome", J Health Popul Nutr, 33, pp.157~167 (2015)
  28. Tahergorabi Z, "The relationship between inflammatory markers, angiogenesis, and obesity", ARYA Atheroscler, 9, pp.247~253 (2013)
  29. Goossens GH, "Adipose tissue oxygen tension : implications for chronic metabolic and inflammatory diseases", Curr Opin Clin Nutr Metab Care, 15, pp.539~546 (2012)
  30. Sun K, "Selective inhibition of hypoxia-inducible factor 1αameliorates adipose tissue dysfunction", Mol Cell Biol, 33, pp.904~917 (2013)
  31. Elias I, "Adipose tissue overexpression of vascular endothelial growth factor protects against diet-induced obesity and insulin resistance", Diabetes, 61, pp.1801~1813 (2012)
  32. Bråkenhielm E, "Adiponectin-induced antiangiogenesis and antitumor activity involve caspasemediated endothelial cell apoptosis", Proc Natl Acad Sci U S A, 101, pp.2476~2481 (2004)
  33. Malavazos AE, "The"lipid accumulation product"is associated with 2-hour postload glucose outcomes in overweight", obese subjects with nondiabetic fasting glucose, 2015, pp.2015, 836941~

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