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Association between serum gonadotropin level and insulin resistance-related parameters in Korean women with polycystic ovary syndrome

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주제분류산부인과학

초록

ObjectiveTo evaluate the relationship between serum gonadotropin level and parameters related to insulin resistance in Korean women with polycystic ovary syndrome (PCOS). MethodsThis retrospective study included 138 women aged 18 to 35 years who were newly diagnosed with PCOS according to the Rotterdam consensus. Participants were divided into three groups based on the serum luteinizing hormone to follicle-stimulating hormone (LH/FSH) ratio in the early follicular phase: group 1 (LH/FSH <1), group 2 (1.0≤ LH/FSH <2.0), and group 3 (LH/FSH ≥2.0). The correlations between the LH/FSH ratio and various metabolic parameters were evaluated using Pearson correlation coefficients. ResultsPatients with higher LH/FSH ratios showed higher total antral follicle counts and higher total ovarian volume. In the comparison of anthropometric and biochemical parameters among the three groups, the waist to hip ratio was the only parameter that differed significantly among the groups (P=0.003). Correlation analysis revealed no significant correlations between serum LH/FSH ratios and biochemical parameters related to insulin resistance. However, after adjustments for age and body mass index, a significant correlation between total cholesterol level and serum LH/FSH ratio was observed (r=0.221, P=0.018). ConclusionMost parameters related to insulin resistance, with the exception of total cholesterol level, are unrelated to the inappropriate pattern of serum gonadotropin secretion in Korean women with PCOS.

Abstract

ObjectiveTo evaluate the relationship between serum gonadotropin level and parameters related to insulin resistance in Korean women with polycystic ovary syndrome (PCOS). MethodsThis retrospective study included 138 women aged 18 to 35 years who were newly diagnosed with PCOS according to the Rotterdam consensus. Participants were divided into three groups based on the serum luteinizing hormone to follicle-stimulating hormone (LH/FSH) ratio in the early follicular phase: group 1 (LH/FSH <1), group 2 (1.0≤ LH/FSH <2.0), and group 3 (LH/FSH ≥2.0). The correlations between the LH/FSH ratio and various metabolic parameters were evaluated using Pearson correlation coefficients. ResultsPatients with higher LH/FSH ratios showed higher total antral follicle counts and higher total ovarian volume. In the comparison of anthropometric and biochemical parameters among the three groups, the waist to hip ratio was the only parameter that differed significantly among the groups (P=0.003). Correlation analysis revealed no significant correlations between serum LH/FSH ratios and biochemical parameters related to insulin resistance. However, after adjustments for age and body mass index, a significant correlation between total cholesterol level and serum LH/FSH ratio was observed (r=0.221, P=0.018). ConclusionMost parameters related to insulin resistance, with the exception of total cholesterol level, are unrelated to the inappropriate pattern of serum gonadotropin secretion in Korean women with PCOS.

참고문헌 (34)

  1. Kuzbari O, "Berek & Novak’s gynecology", pp.1075~1080 (2012), Lippincott Williams &Wilkins
  2. Rotterdam ESHRE, "ASRM-Sponsored PCOS Consensus Workshop Group", Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome, 2004, pp.81, 19~25
  3. Carmina E, "Polycystic ovary syndrome(PCOS) : arguably the most common endocrinopathy is associated with significant morbidity in women", J Clin Endocrinol Metab, 84, pp.1897~1899 (1999)
  4. Fritz MA, "Clinical gynecologic endocrinology and infertility", pp.501~518 (2011), Lippincott Williams & Wilkins
  5. 이정렬, "여성 생식에서 Anti-Müllerian Hormone의 역할", Obstetrics & Gynecology Science, 52(3), pp.285~300 (2009), 대한산부인과학회
  6. Hsu MI, "Inappropriate gonadotropin secretion in polycystic ovary syndrome", Fertil Steril, 91, pp.1168~1174 (2009)
  7. Kubota T, "Update in polycystic ovary syndrome : new criteria of diagnosis and treatment in Japan", Reprod Med Biol, 12, pp.71~77 (2013)
  8. Ehrmann DA, "Polycystic ovary syndrome", N Engl J Med, 352, pp.1223~1236 (2005)
  9. Carmina E, "Use of fasting blood to assess the prevalence of insulin resistance in women with polycystic ovary syndrome", Fertil Steril, 82, pp.661~665 (2004)
  10. Lin JF, "Exploration of the classification of polycystic ovarian syndrome", Zhonghua Fu Chan Ke Za Zhi, 41, pp.684~688 (2006)
  11. Chae SJ, "Clinical and biochemical characteristics of polycystic ovary syndrome in Korean women", Hum Reprod, 23, pp.1924~1931 (2008)
  12. de Kat AC, "Anti-Mullerian hormone as a marker of ovarian reserve in relation to cardio-metabolic health: a narrative review", Maturitas, 80, pp.251~257 (2015)
  13. La Marca A, "Mullerian-inhibiting substance in women with polycystic ovary syndrome : relationship with hormonal and metabolic characteristics", Fertil Steril, 82, pp.970~972 (2004)
  14. Nardo LG, "The relationships between AMH, androgens, insulin resistance and basal ovarian follicular status in non-obese subfertile women with and without polycystic ovary syndrome", Hum Reprod, 24, pp.2917~2923 (2009)
  15. Chun S, "1-h postprandial glucose level is related to the serum anti-Mullerian hormone level in women with polycystic ovary syndrome", Gynecol Endocrinol, 31, pp.815~818 (2015)
  16. 심아라, "다낭성난소증후군에서 성선자극호르몬 분비 이상과 임상적, 호르몬, 대사적 특성과의 연관성", Obstetrics & Gynecology Science, 54(11), pp.659~665 (2011), 대한산부인과학회
  17. Arroyo A, "Inappropriate gonadotropin secretion in polycystic ovary syndrome:influence of adiposity", J Clin Endocrinol Metab, 82, pp.3728~3733 (1997)
  18. Kim JJ, "Assessment of hirsutism among Korean women : results of a randomly selected sample of women seeking pre-employment physical check-up", Hum Reprod, 26, pp.214~220 (2011)
  19. Waldstreicher J, "Hyperfunction of the hypothalamic-pituitary axis in women with polycystic ovarian disease: indirect evidence for partial gonadotroph desensitization", J Clin Endocrinol Metab, 66, pp.165~172 (1988)
  20. Cho LW, "The LH", FSH ratio has little use in diagnosing polycystic ovarian syndrome, 2006, pp.43(Pt 3), 217~219
  21. Minakami H, "Prolactin release in polycystic ovarian syndrome", Endocrinol Jpn, 35, pp.303~310 (1988)
  22. Papaleo E, "Cabergoline influences ovarian stimulation in hyperprolactinaemic patients with polycystic ovary syndrome", Hum Reprod, 16, pp.2263~2266 (2001)
  23. Wiser A, "Effect of high LH", FSH ratio on women with polycystic ovary syndrome undergoing in vitro maturation treatment, 2013, pp.58, 219~223
  24. 전성욱, "Serum luteinizing hormone level and luteinizing hormone", follicle-stimulating hormone ratio but not serum anti-Müllerian hormone level is related to ovarian volume in Korean women with polycystic ovary syndrome, 2014, pp.41(2), 86~91[DOI]
  25. Sikka P, "Ultrasonography of the ovaries and its correlation with clinical and endocrine parameters in infertile women with PCOS", Int J Fertil Womens Med, 52, pp.41~47 (2007)
  26. Carmina E, "Evidence for altered adipocyte function in polycystic ovary syndrome", Eur J Endocrinol, 152, pp.389~394 (2005)
  27. Kurioka H, "Glucose intolerance in Japanese patients with polycystic ovary syndrome", Arch Gynecol Obstet, 275, pp.169~173 (2007)
  28. Banaszewska B, "Incidence of elevated LH", FSH ratio in polycystic ovary syndrome women with normo-and hyperinsulinemia, 2003, pp.48, 131~134
  29. Patel K, "Increased luteinizing hormone secretion in women with polycystic ovary syndrome is unaltered by prolonged insulin infusion", J Clin Endocrinol Metab, 88, pp.5456~5461 (2003)
  30. American Diabetes Association, "Postprandial blood glucose", Diabetes Care, 24, pp.775~778 (2001), American Diabetes Association
  31. Abdul-Ghani MA, "What is the best predictor of future type 2 diabetes?", Diabetes Care, 30, pp.1544~1548 (2007)
  32. Abdul-Ghani MA, "Fasting versus postload plasma glucose concentration and the risk for future type 2 diabetes : results from the Botnia Study", Diabetes Care, 32, pp.281~286 (2009)
  33. Chen H, "Assessing the predictive accuracy of QUICKI as a surrogate index for insulin sensitivity using a calibration model", Diabetes, 54, pp.1914~1925 (2005)
  34. Hrebicek J, "Detection of insulin resistance by simple quantitative insulin sensitivity check index QUICKI for epidemiological assessment and prevention", J Clin Endocrinol Metab, 87, pp.144~147 (2002)

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