Adipokines, insulin-like growth factor binding protein-3 levels, and insulin sensitivity in women with polycystic ovary syndrome
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Background/Aims: Many women with polycystic ovary syndrome (PCOS) exhibit insulin resistance. Adipose tissue plays an important role in insulin resistance,and adipokines including tumor necrosis factor (TNF)-α and adiponectin are altered in PCOS. Insulin-like growth factor binding protein-3 (IGFBP-3), alone or in conjunction with other adipokines, is also associated with insulin resistance. We evaluated the effects of TNF-α, adiponectin, and IGFBP-3 on insulin sensitivity and the relationships among these proteins in women with PCOS. Methods: We recruited 40 women with PCOS and 40 age- and body mass index (BMI)-matched regular cycling women (controls). The women were divided into obese (BMI ≥ 25 kg/m2) and nonobese (BMI < 25 kg/m2) groups. Anthropometric measurements were performed, and serum levels of TNF-α, adiponectin, and IGFBP-3 were determined. Insulin sensitivity was estimated using the metabolic clearance rate (MCR) of glucose calculated from the oral glucose tolerance test. Results: Serum levels of TNF-α and IGFBP-3 did not differ between the PCOS and control groups, but adiponectin levels in the PCOS group were lower than those in control women in the nonobese group (p < 0.05). TNF-α, adiponectin,and IGFBP-3 levels were not correlated with each other in women with PCOS, but a significant positive correlation was observed between adiponectin levels and MCR (p < 0.05). Multiple regression analysis revealed that adiponectin levels were significantly associated with insulin sensitivity (p < 0.05) in women with PCOS. Conclusions: IGFBP-3 and TNF-α levels were not associated with insulin sensitivity, but adiponectin levels were related to insulin sensitivity in women with PCOS.
Abstract
Background/Aims: Many women with polycystic ovary syndrome (PCOS) exhibit insulin resistance. Adipose tissue plays an important role in insulin resistance,and adipokines including tumor necrosis factor (TNF)-α and adiponectin are altered in PCOS. Insulin-like growth factor binding protein-3 (IGFBP-3), alone or in conjunction with other adipokines, is also associated with insulin resistance. We evaluated the effects of TNF-α, adiponectin, and IGFBP-3 on insulin sensitivity and the relationships among these proteins in women with PCOS. Methods: We recruited 40 women with PCOS and 40 age- and body mass index (BMI)-matched regular cycling women (controls). The women were divided into obese (BMI ≥ 25 kg/m2) and nonobese (BMI < 25 kg/m2) groups. Anthropometric measurements were performed, and serum levels of TNF-α, adiponectin, and IGFBP-3 were determined. Insulin sensitivity was estimated using the metabolic clearance rate (MCR) of glucose calculated from the oral glucose tolerance test. Results: Serum levels of TNF-α and IGFBP-3 did not differ between the PCOS and control groups, but adiponectin levels in the PCOS group were lower than those in control women in the nonobese group (p < 0.05). TNF-α, adiponectin,and IGFBP-3 levels were not correlated with each other in women with PCOS, but a significant positive correlation was observed between adiponectin levels and MCR (p < 0.05). Multiple regression analysis revealed that adiponectin levels were significantly associated with insulin sensitivity (p < 0.05) in women with PCOS. Conclusions: IGFBP-3 and TNF-α levels were not associated with insulin sensitivity, but adiponectin levels were related to insulin sensitivity in women with PCOS.
참고문헌 (28)
- Dunaif A, "Current concepts in the polycystic ovary syndrome", Annu Rev Med, 52, pp.401~419 (2001)
- Dunaif A., "Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis", Endocr Rev, 18, pp.774~800 (1997)
- 오지영, "Serum C-Reactive Protein Levels in Normal-Weight Polycystic Ovary Syndrome", The Korean Journal of Internal Medicine, 24(4), pp.350~355 (2009), 대한내과학회
- Ruan H, "Insulin resistance in adipose tissue: direct and indirect effects of tumor necrosis factor- alpha", Cytokine Growth Factor Rev, 14, pp.447~455 (2003)
- Tarkun I, "Association between circulating tumor necrosis factor-alpha, interleukin-6, and insulin resistance in normal-weight women with polycystic ovary syndrome", Metab Syndr Relat Disord, 4, pp.122~128 (2006)
- Toulis KA, "Adiponectin levels in women with polycystic ovary syndrome: a systematic review and a meta-analysis", Hum Reprod Update, 15, pp.297~307 (2009)
- Weyer C, "Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia", J Clin Endocrinol Metab, 86, pp.1930~1935 (2001)
- Firth SM, "Cellular actions of the insulin- like growth factor binding proteins", Endocr Rev, 23, pp.824~854 (2002)
- Murphy LJ., "The role of the insulin-like growth factors and their binding proteins in glucose homeostasis", Exp Diabesity Res, 4, pp.213~224 (2003)
- Liu B, "Direct functional interactions between insulin-like growth factor-binding protein-3 and retinoid X receptor-alpha regulate transcriptional signaling and apoptosis", J Biol Chem, 275, pp.33607~33613 (2000)
- Toth B, "Peroxisome proliferator-activated receptors: new players in the field of reproduction", Am J Reprod Immunol, 58, pp.289~310 (2007)
- Kim HS, "Insulin-like growth factor binding protein-3 induces insulin resistance in adipocytes in vitro and in rats in vivo", Pediatr Res, 61, pp.159~164 (2007)
- Besset V, "Tumor necrosis factor alpha stimulates insulin-like growth factor binding protein 3 expression in cultured porcine Sertoli cells", Endocrinology, 137, pp.296~303 (1996)
- Rozen F, "Antiproliferative action of tumor necrosis factor-alpha on MCF-7 breastcancer cells is associated with increased insulin-like growth factor binding protein-3 accumulation", Int J Oncol, 13, pp.865~869 (1998)
- Rajah R, "Insulin-like growth factor binding protein-3 mediates tumor necrosis factoralpha- induced apoptosis: role of Bcl-2 phosphorylation", Cell Growth Differ, 13, pp.163~171 (2002)
- Fauser BC, "Consensus on women's health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE", ASRM-Sponsored 3rd PCOS Consensus Workshop Group, 2012, pp.97, 28~38
- Vermeulen A, "A critical evaluation of simple methods for the estimation of free testosterone in serum", J Clin Endocrinol Metab, 84, pp.3666~3672 (1999)
- Stumvoll M, "Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity", Diabetes Care, 23, pp.295~301 (2000)
- World Health Organization, "Regional Off ice for the Western Pacific; International Association for the Study of Obesity; International Obesity Task Force, In The Asia- Pacific Perspective: Redefining Obesity and Its Treatment" (2000), Health Communications Australia
- Bremer AA, "The serine phosphorylation hypothesis of polycystic ovary syndrome: a unifying mechanism for hyperandrogenemia and insulin resistance", Fertil Steril, 89, pp.1039~1048 (2008)
- Villa J, "Adipose tissue dysfunction in polycystic ovary syndrome", Curr Diab Rep, 11, pp.179~184 (2011)
- Festa A, "Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS)", Circulation, 102, pp.42~47 (2000)
- Wickham EP 3rd, "Total and high-molecular weight adiponectin in women with the polycystic ovary syndrome", Metabolism, 60, pp.366~372 (2011)
- Escobar-Morreale HF, "Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis", Fertil Steril, 95, pp.1048~1058 (2011)
- Boney CM, "Expression of insulin-like growth factor-I (IGF-I) and IGFbinding proteins during adipogenesis", Endocrinology, 135, pp.1863~1868 (1994)
- Wabitsch M, "IGF-Iand IGFBP-3-expression in cultured human preadipocytes and adipocytes", Horm Metab Res, 32, pp.555~559 (2000)
- Chan SS, "Insulinlike growth factor binding protein-3 leads to insulin resistance in adipocytes", J Clin Endocrinol Metab, 90, pp.6588~6595 (2005)
- Ricort JM, "Insulin-like growth factor-binding protein-3 activates a phosphotyrosine phosphatase: effects on the insulin-like growth factor signaling pathway", J Biol Chem, 277, pp.19448~19454 (2002)