Blood level of adipokines and nutritional status variables in adolescent pregnancy
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
ObjectiveTo evaluate the serum levels of adiponectin and leptin and their relationship with nutritional variables duringpregnancy in adolescents. MethodsThis prospective cohort study evaluated eutrophic pregnant adolescents (body mass index [BMI], 18.5–24.9 kg/m2) during the 3 gestational trimesters (first, 10–14 weeks; second, 24–28 weeks; and third, 30–34 weeks). Serumadiponectin and leptin concentrations were measured using the enzyme-linked immunosorbent assay method. Therelationship of these adipokines with the pre-gestational BMI, gestational weight gain, weight at the time of samplecollection, and newborn weight were evaluated. Analysis of variance and the Kruskal-Wallis test were used forstatistical analysis. ResultsThe study group comprised 62 pregnant adolescents. The serum concentration of adiponectin showed a significantdifference between the first and third trimesters (P=0.003), which decreased during pregnancy, but unrelated tonutritional variables. Serum leptin levels increased throughout the pregnancy (P<0.0001) and showed a positivecorrelation with pre-gestational BMI, total weight gain, pregnancy weight at the time of sample collection, andnewborns’ weight. ConclusionSerum levels of adiponectin and leptin vary inversely throughout pregnancy. This pattern in adolescents is similar tothat observed in adults. Moreover, leptin concentrations increased throughout pregnancy, and they were positivelycorrelated with all variables evaluated.
Abstract
ObjectiveTo evaluate the serum levels of adiponectin and leptin and their relationship with nutritional variables duringpregnancy in adolescents. MethodsThis prospective cohort study evaluated eutrophic pregnant adolescents (body mass index [BMI], 18.5–24.9 kg/m2) during the 3 gestational trimesters (first, 10–14 weeks; second, 24–28 weeks; and third, 30–34 weeks). Serumadiponectin and leptin concentrations were measured using the enzyme-linked immunosorbent assay method. Therelationship of these adipokines with the pre-gestational BMI, gestational weight gain, weight at the time of samplecollection, and newborn weight were evaluated. Analysis of variance and the Kruskal-Wallis test were used forstatistical analysis. ResultsThe study group comprised 62 pregnant adolescents. The serum concentration of adiponectin showed a significantdifference between the first and third trimesters (P=0.003), which decreased during pregnancy, but unrelated tonutritional variables. Serum leptin levels increased throughout the pregnancy (P<0.0001) and showed a positivecorrelation with pre-gestational BMI, total weight gain, pregnancy weight at the time of sample collection, andnewborns’ weight. ConclusionSerum levels of adiponectin and leptin vary inversely throughout pregnancy. This pattern in adolescents is similar tothat observed in adults. Moreover, leptin concentrations increased throughout pregnancy, and they were positivelycorrelated with all variables evaluated.
참고문헌 (31)
- Chedraui P, "Pregnancy among young adolescents : trends, risk factors and maternal-perinatal outcome", J Perinat Med, 36, pp.256~259 (2008)
- "State of world population 2013. Motherhood in childhood: facing the challenge of adolescent pregnancy" (2013)[URL]
- Moulin CM, "Impact of adiposity on immunological parameters", Arq Bras Endocrinol Metabol, 53, pp.183~189 (2009)
- Mazaki-Tovi S, "Maternal serum adiponectin multimers in gestational diabetes", J Perinat Med, 37, pp.637~650 (2009)
- Low CF, "Adiponectin SNP45TG is associated with gestational diabetes mellitus", Arch Gynecol Obstet, 283, pp.1255~1260 (2011)
- Yadav A, "Role of leptin and adiponectin in insulin resistance", Clin Chim Acta, 417, pp.80~84 (2013)
- Henson MC, "Leptin in pregnancy : an update", Biol Reprod, 74, pp.218~229 (2006)
- Vernini JM, "Maternal adipokines and insulin as biomarkers of pregnancies complicated by overweight and obesity", Diabetol Metab Syndr, 8, pp.68~ (2016)
- Institute of Medicine, "Weight gain during pregnancy: reexaminig the guidelines" (2009), The National Academies Press
- Lage M, "Serum leptin levels in women throughout pregnancy and the postpartum period and in women suffering spontaneous abortion", Clin Endocrinol(Oxf), 50, pp.211~216 (1999)
- Al-Atawi FS, "Leptin concentration during different trimesters of pregnancy and its relation to other pregnancy hormones", Saudi Med J, 25, pp.1617~1622 (2004)
- Tommaselli GA, "Do serum leptin levels have a role in the prediction of pregnancy outcome in case of threatened miscarriage?", Clin Endocrinol (Oxf), 65, pp.772~775 (2006)
- Georgiou HM, "Screening for biomarkers predictive of gestational diabetes mellitus", Acta Diabetol, 45, pp.157~165 (2008)
- Valle M, "Relationship between high plasma leptin concentrations and metabolic syndrome in obese pre-pubertal children", Int J Obes Relat Metab Disord, 27, pp.13~18 (2003)
- Sagawa N, "Role of leptin in pregnancy--a review", Placenta, 23(Suppl A), pp.S80~86 (2002)
- Valsamakis G, "The effects of adipose tissue and adipocytokines in human pregnancy", Ann N Y Acad Sci, 1205, pp.76~81 (2010)
- Ryan EA, "Hormones and insulin resistance during pregnancy", Lancet, 362, pp.1777~1778 (2003)
- Manoharan B, "Adipokine levels and their association with insulin resistance and fetal outcomes among the newborns of Indian gestational diabetic mothers", Saudi Med J, 40, pp.353~359 (2019)
- Nanda S, "Prediction of gestational diabetes mellitus by maternal factors and biomarkers at 11 to 13 weeks", Prenat Diagn, 31, pp.135~141 (2011)
- Hara K, "Adiponectin : an adipokine linking adipocytes and type 2 diabetes in humans", Curr Diab Rep, 5, pp.136~140 (2005)
- Fuglsang J, "A longitudinal study of serum adiponectin during normal pregnancy", BJOG, 113, pp.110~113 (2006)
- Vitoratos N, "Pre-and early post-partum adiponectin and interleukin-1beta levels in women with and without gestational diabetes", Hormones(Athens), 7, pp.230~236 (2008)
- Hedderson MM, "Low prepregnancy adiponectin concentrations are associated with a marked increase in risk for development of gestational diabetes mellitus", Diabetes Care, 36, pp.3930~3937 (2013)
- López-Bermejo A, "Maternal soluble tumour necrosis factor receptor type 2(sTNFR2)and adiponectin are both related to blood pressure during gestation and infant’s birthweight", Clin Endocrinol(Oxf), 61, pp.544~552 (2004)
- McLachlan KA, "leptin and CRP relate to insulin resistance in pregnancy? Studies in women with and without gestational diabetes, during and after pregnancy", Diabetes Metab Res Rev, 22, pp.131~138 (2006)
- Misra VK, "Maternal serum leptin during pregnancy and infant birth weight: the influence of maternal overweight and obesity", Obesity (Silver Spring), 21, pp.1064~1069 (2013)
- Baratto I, "Adiponectin and leptin serum levels in normal adolescent pregnancies", J Matern Fetal Neonatal Med, 11, pp.1~6 (2019)
- Duarte AVB, "Leptin, additional link to the pathophysiology of preeclampsia?", Rev Bras Ginecol Obstet, 23, pp.283~287 (2001)
- Jones RL, "Relationship between maternal growth, infant birthweight and nutrient partitioning in teenage pregnancies", BJOG, 117, pp.200~211 (2010)
- Josefson JL, "Maternal leptin predicts adiposity of the neonate", Horm Res Paediatr, 81, pp.13~19 (2014)
- Caprio M, "Leptin in reproduction", Trends Endocrinol Metab, 12, pp.65~72 (2001)