제대혈 Adiponectin과 IGF-I이 태아성장에 미치는 영향
Correlation of Cord Serum Adiponectin and IGF-I with Fetal Growth in Healthy Term Neonates
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Purpose : The purpose of this study was to evaluate the relationship between cord serum adiponectin (APN) and IGF-I concentrations and fetal growth. Methods : Umbilical cord serum APN and IGF-I concentrations were measured in healthy term singleton deliveries (n=72). The association of cord serum APN and IGF-I concentrations was evaluated in relation to birth weight, height, head circumference, gender, ponderal index, placental weight, feto-placental (F/P) weight ratio, maternal weight gain, and maternal body mass index (BMI). Results : The mean cord serum APN was 29.2±10.46 μg/mL. The cord serum APN and birth weight demonstrated a bell-shape relationship. The cord serum APN concentration was higher in females than males (P=0.001). The cord serum APN was negatively correlated with maternal BMI (r=-0.301, P=0.027), but the mean cord serum APN concentration was not correlated with birth height, birth head circumference, ponderal index, placental weight, F/P ratio, or maternal weight gain. The mean cord serum concentrations of IGF-I was 51.26±21.54 ng/mL. The cord serum IGF-I concentration was positively correlated with birth weight (r=0.312, P=0.009), but not birth height, ponderal index, placental weight, F/P weight ratio, or maternal BMI. Conclusion : APN demonstrated a bell-shaped relationship with birth weight in healthy term infants. IGF-I was highly correlated with fetal growth, especially birth weight.
Abstract
Purpose : The purpose of this study was to evaluate the relationship between cord serum adiponectin (APN) and IGF-I concentrations and fetal growth. Methods : Umbilical cord serum APN and IGF-I concentrations were measured in healthy term singleton deliveries (n=72). The association of cord serum APN and IGF-I concentrations was evaluated in relation to birth weight, height, head circumference, gender, ponderal index, placental weight, feto-placental (F/P) weight ratio, maternal weight gain, and maternal body mass index (BMI). Results : The mean cord serum APN was 29.2±10.46 μg/mL. The cord serum APN and birth weight demonstrated a bell-shape relationship. The cord serum APN concentration was higher in females than males (P=0.001). The cord serum APN was negatively correlated with maternal BMI (r=-0.301, P=0.027), but the mean cord serum APN concentration was not correlated with birth height, birth head circumference, ponderal index, placental weight, F/P ratio, or maternal weight gain. The mean cord serum concentrations of IGF-I was 51.26±21.54 ng/mL. The cord serum IGF-I concentration was positively correlated with birth weight (r=0.312, P=0.009), but not birth height, ponderal index, placental weight, F/P weight ratio, or maternal BMI. Conclusion : APN demonstrated a bell-shaped relationship with birth weight in healthy term infants. IGF-I was highly correlated with fetal growth, especially birth weight.
참고문헌 (17)
- Gluckman PD, "Clinical review 68: The endocrine regulation of fetal growth in late gestation: the role of insulin growth factors", J Clin Endocrinol Metab, pp.1047~1050 (1995)
- Randhawa R, "The role of the insulinlike growth factor system in prenatal growth", insulinlike growth factor system in prenatal growth. Mol Genet Metab, 86, pp.84~90 (2005)
- López-Bermejo A, "Both intrauterine growth restriction and postnatal growth influence childhood serum concentrations of adiponectin", Clin Endocrinol (Oxf), 61, pp.339~346 (2004)
- Corbetta S, "Adiponectin expression in human fetal tissue during mid- and late gestation", J Clin Endocrinol Metab, 90, pp.2397~2402 (2005)
- Kadowaki K, "Adiponectin concentration in umbilical cord serum is positively associated with the weight ratio of fetus to placenta", J Clin Endocrinol Metab, 91, pp.5090~5094 (2006)
- Lubchenco LO, "Intrauterine growth in length and head circumference as estimated from live births at gestational ages from 26 to 42 weeks", Pediatrics, 37, pp.403~408 (1966)
- Allan GJ, "Insulin-like growth factor axis during embryonic development", Reproduction, 122, pp.31~39 (2001)
- Woods KA, "Insulin-like growth factor I gene deletion causing intrauterine growth retardation and svere short stature", Acta Padiatr Supp, 423, pp.39~45 (1997)
- Akman I, "Maternal zinc and cord blood zinc, insulin-like growth factor-1, and insulin-like growth factor binding protein-3 levels in small-for-gestational-age newborns", Clin Exp Obstet Gynecol, 33, pp.238~240 (2006)
- Takaya J, "Intracellular magnesium and adipokines in umbilical cord plasma and infant birth size", Pediatr Res, 62, pp.700~703 (2007)
- Hales CN, "The thrifty phenotype hypothesis", Br Med Bull, 60, pp.5~20 (2001)
- Sandhu MS, "Circulating concentrations of insulin-like growth factor-I and development of glucose intolerance: a prospective observational study", Lancet, 359, pp.1740~1745 (2002)
- Lihn AS, "Adiponectin: action, regulation and association to insulin sensitivity", Obes Rev, 6, pp.13~21 (2005)
- Giapros V, "Serum adiponectin and leptin levels and insulin resistance in children born large for gestational age are affected by the degree of overweight", Clin Endocrinol (Oxf), 66, pp.353~359 (2007)
- Tsai PJ, "Cord plasma concentrations of adiponectin and leptin in healthy term neonates: positive correlation with birthweight and neonatal adiposity", Clin Endocrinol (Oxf), 61, pp.88~93 (2004)
- Sivan E, "Adiponectin in human cord blood: relation to fetal birth weight and gender", J Endocrinol Metab, 88, pp.5656~5660 (2003)
- Mazaki-Tovi S, "Cord blood adiponectin in largefor- gestational age newborns", Am J Obstet Gynecol, 193, pp.1238~1242 (2005)