신생아의 제대 혈액 및 산모의 혈액내 adiponectin 농도와 신생아의 체중과의 연관성에 관한 연구
Correlations between umbilical and maternal serum adiponectin levels and neonatal birthweight
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목적: 지방세포에서 생성되는 adiponectin은 insulin에 대한 반응성을 높이며, 내피세포와 대식세포에서는 항 염증작용을 보인다. 최근 연구들을 통해 adiponectin은 산모의 혈중에 높은 농도로 존재하며 특히 임신 후반기로 갈수록 그 농도가 증가하는 것으로 알려져 adiponectin이 임신시 산모의 에너지 대사에 중요한 역할을 하는 것으로 알려졌다. 하지만 태아에서의 adiponectin의 역할에 대해서는 많이 알려진 바가 없다. 따라서 본 연구에서는 제대 혈액내 adiponectin이 존재하는지 확인하고 또한 산모의 혈액내 adiponectin의 농도, 태아의 체중, 산모의 체질량지수 등과의 연관성을 알아보고자 한다. 연구 방법: 30명의 산모와 그의 신생아를 대상으로 산모의 혈액 및 제대 혈액을 분만시 채취하여 ELISA방법으로 adiponectin, leptin, insulin을 측정하였다. 결과: 제대 혈액내 adiponectin농도가 산모의 혈액내 농도보다 통계학적으로 의미있게 높았다 (14.82±3.66 µg/mL vs 4.73±1.87, p<0.001) 또한 제대 혈액내 adiponectin농도는 신생아의 출생체중과 관련이 있었으나 (r=0.459, p=0.011) 산모의 혈액내 adiponectin의 농도, 산모의 체질량지수, 재대 혈액내 leptin, insulin농도와는 관련이 없었다. 결론: 제대 혈액내 높은 농도로 존재하는 adiponectin은 산모뿐만 아니라 태아의 에너지 항상성에 중요한 역할을 할 것으로 사료된다.
Abstract
Objective: Adiponectin is an adipocyte-derived hormone with profound insulin sensitizing, anti-inflammatory, and antiatherogenic effects. Apart from its obvious potential as a mediator of adult metabolic syndrome, in pregnancy, adiponectin could have a significant role in regulating energy homeostasis. However, correlations between umbilical cord and maternal serum adiponectin levels and neonatal birthweights are far from understood. The purpose of the present study was to clarify correlations between umbilical cord and maternal serum adiponectin levels and neonatal birthweights. Methods: The study included 30 healthy mothers who had given birth to healthy neonates. Adiponectin levels in maternal serum and umbilical cord serum were determined by ELISA and analysed. Results: The ranges of adiponectin levels for umbilical cord and maternal serum were 7.12-24.93 µg/mL and 1.76-8.20 µg/mL, respectively. Umbilical cord adiponectin levels (14.82±3.66 µg/mL) were significantly higher than maternal serum levels (4.73±1.87)(p<0.001). Umbilical cord adiponectin levels were correlated positively with neonatal birthweights (r=0.459, p=0.011). No significant differences in adiponectin levels were found between female and male neonates. In addition, there was no correlation between umbilical cord adiponectin levels and maternal serum adiponectin levels, maternal body mass index, umbilical leptin, or insulin levels. Conclusion: The levels of adiponectin were higher in umbilical cord than in maternal serum. The adiponectin levels in umbilical cord were found to correlate positively with neonatal birthweights. Therefore, adiponectin may be involved in fetal energy metabolism in pregnancy.
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