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The Anti-allergy Effects of Injinho-tang on the RBL-2H3 cells

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주제분류한의학

초록

茵蔯蒿湯은 한의학에서 여러 가지 질환에 사용되어 왔다. 특히 간경의 濕熱로 인한 질환에 습열을 제거함으로써 證 의 완화에 많은 응용이 되외 왔다. 본 연구는 濕熱로 인한 질환중의 하나인 아토피 피부염에 그동안 응용이 적은 茵 蔯蒿湯을 실험적으로 응용함으로써 임상적인 가치를 가질 수 있는 지에 대한 기초연구를 진행하였다. 본 실험에 사용 된 세포주는 rat leukemia (RBL-2H3) cells로 茵蔯蒿湯은 알레르기와 관련된 사이토카인인 tumor necrosis factor (TNF)-α, interleukin (IL)-4를 용량의존적으로 억제하였지만 세포독성은 일으키지 않았다. 그리고 동물실험에서 茵蔯 蒿湯은 PCA반응에서 충분한 억제효과를 나타내었다. 또한 Compound 48/80으로 유도된 anaphylaxis shock도 용량 의존적으로 억제함이 밝혀졌다

참고문헌 (34)

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