Glomus Tumor of the Stomach: A Clinicopathologic Analysis of 10 Cases and Review of the Literature
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background/Aims: Gastric glomus tumors are extremely rare, and presurgical confirmation is often impossible. The identification of clinical and radiologic characteristics of this tumor type is important for preoperative diagnosis and treatment planning. Methods: In this study, we analyzed 10cases of gastric glomus tumors resected at a single institute over 9 years. Results: Eight of the patients were men and 2were women, with a mean age of 49 years. Five patients presented with abdominal discomfort or pain, 1 presented with anemia, and the remaining 4 cases were found incidentally during endoscopic examinations. The most common location of the tumor was the antrum (n=7), followed by the low (n=2) and high body (n=1). Although the endoscopic ultrasonography fi ndings were variable, contrast-enhanced computed tomography generally showed a strong homogeneous enhancement. The resected tumors were well-demarcated solid masses with sizes ranging from 1.0 to 3.6 cm. Microscopically,the masses were composed of abundant vascular channels with clusters of uniform and round glomus cells. There was no evidence of recurrence after complete surgical resection. Conclusions: Gastric glomus tumors are unusual,distinct lesions that should be considered in the differential diagnosis of a gastric submucosal mass. Unlike their deep soft tissue counterparts, most glomus tumors in the stomach are benign.
Abstract
Background/Aims: Gastric glomus tumors are extremely rare, and presurgical confirmation is often impossible. The identification of clinical and radiologic characteristics of this tumor type is important for preoperative diagnosis and treatment planning. Methods: In this study, we analyzed 10cases of gastric glomus tumors resected at a single institute over 9 years. Results: Eight of the patients were men and 2were women, with a mean age of 49 years. Five patients presented with abdominal discomfort or pain, 1 presented with anemia, and the remaining 4 cases were found incidentally during endoscopic examinations. The most common location of the tumor was the antrum (n=7), followed by the low (n=2) and high body (n=1). Although the endoscopic ultrasonography fi ndings were variable, contrast-enhanced computed tomography generally showed a strong homogeneous enhancement. The resected tumors were well-demarcated solid masses with sizes ranging from 1.0 to 3.6 cm. Microscopically,the masses were composed of abundant vascular channels with clusters of uniform and round glomus cells. There was no evidence of recurrence after complete surgical resection. Conclusions: Gastric glomus tumors are unusual,distinct lesions that should be considered in the differential diagnosis of a gastric submucosal mass. Unlike their deep soft tissue counterparts, most glomus tumors in the stomach are benign.
참고문헌 (20)
- Tsuneyoshi M, "Glomus tumor: a clinicopathologic and electron microscopic study", Cancer, 50, pp.1601~1607 (1982)
- Miettinen M, "Gastrointestinal glomus tumors: a clinicopathologic, immunohistochemical, and molecular genetic study of 32 cases", Am J Surg Pathol, 26, pp.301~311 (2002)
- Kang JH, "Role of EUS and MDCT in the diagnosis of gastric submucosal tumors according to the revised pathologic concept of gastrointestinal stromal tumors", Eur Radiol, 19, pp.924~934 (2009)
- Polkowski M, "Endoscopic ultrasound and endoscopic ultrasoundguided fine-needle biopsy for the diagnosis of malignant submucosal tumors", Endoscopy, 37, pp.635~645 (2005)
- Lee MJ, "Gastric true leiomyoma: computed tomographic findings and pathological correlation", J Comput Assist Tomogr, 31, pp.204~208 (2007)
- Chak A, "EUS in submucosal tumors", Gastrointest Endosc, 56(4 Suppl), pp.S43~S48 (2002)
- Park SH, "Unusual gastric tumors: radiologic-pathologic correlation", Radiographics, 19, pp.1435~1446 (1999)
- Debol SM, "Glomus tumor of the stomach: cytologic diagnosis by endoscopic ultrasound-guided fine-needle aspiration", Diagn Cytopathol, 28, pp.316~321 (2003)
- Gu M, "Diagnosis of gastric glomus tumor by endoscopic ultrasound-guided fine needle aspiration biopsy: a case report with cytologic, histologic and immunohistochemical studies", Acta Cytol, 46, pp.560~566 (2002)
- Imamura A, "Glomus tumor of the stomach: endoscopic ultrasonographic findings", Am J Gastroenterol, 89, pp.271~272 (1994)
- Kim JK, "Glomus tumor of the stomach: CT findings", Abdom Imaging, 26, pp.303~305 (2001)
- Levy AD, "Gastrointestinal stromal tumors: radiologic features with pathologic correlation", Radiographics, 23, pp.283~304 (2003)
- Bader TR, "MRI of carcinoid tumors: spectrum of appearances in the gastrointestinal tract and liver", J Magn Reson Imaging, 14, pp.261~269 (2001)
- Park SH, "Heterotopic pancreas of the stomach: CT findings correlated with pathologic findings in six patients", Abdom Imaging, 25, pp.119~123 (2000)
- Kunkel JM, "Glomus tumor: a benign gastric neoplasm", Mil Med, 153, pp.417~418 (1988)
- Appelman HD, "Glomus tumors of the stomach", Cancer, 23, pp.203~213 (1969)
- Kanwar YS, "Glomus tumor of the stomach: an ultrastructural study", Arch Pathol, 99, pp.392~397 (1975)
- Folpe AL, "Atypical and malignant glomus tumors: analysis of 52 cases, with a proposal for the reclassification of glomus tumors", Am J Surg Pathol, 25, pp.1~12 (2001)
- Miettinen M, "Glomus tumor cells: evaluation of smooth muscle and endothelial cell properties", Virchows Arch B Cell Pathol Incl Mol Pathol, 43, pp.139~149 (1983)
- Porter PL, "The immunophenotype of hemangiopericytomas and glomus tumors, with special reference to muscle protein expression: an immunohistochemical study and review of the literature", Mod Pathol, 4, pp.46~52 (1991)