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Evolutionary History of the Helicobacter pylori Genome: Implications for Gastric Carcinogenesis

Pelayo Correa|M. Blanca Piazuelo
거트앤리버 소화기연관학회협의회|2012.01|Gut and Liver|제6권 제1호|pp. 21-28

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참고문헌

키워드

Helicobacter pyloriGenomeGastric carcinogenesis

초록

The genome of the bacterium Helicobacter pylori has evolved over the millennia since its migration out of Africa along with its human host approximately 60,000 years ago. Human migrations,after thousands of years of permanent settlement in those lands, resulted in seven prototypes of genetic populations of H. pylori with distinct geographical distributions. In all continents, present day isolates of H. pylori have molecular markers that refl ect population migrations. The colonization of the Americas as well as the slave trade introduced European and African strains to the New World. The relationship between H. pylori genome and gastric cancer rates is linked to the presence of the cagA gene, but the knowledge on this subject is incomplete because other genes may be involved in certain populations. A new situation for Homo sapiens is the absence of H. pylori colonization in certain, mostly affluent, populations, apparently brought about by improved home sanitation and widespread use of antibiotics during the last decades. The disappearance of H. pylori from the human microbiota may be linked to emerging epidemics of esophageal adenocarcinoma, some allergic diseases such as asthma and some autoimmune disorders.

Abstract

The genome of the bacterium Helicobacter pylori has evolved over the millennia since its migration out of Africa along with its human host approximately 60,000 years ago. Human migrations,after thousands of years of permanent settlement in those lands, resulted in seven prototypes of genetic populations of H. pylori with distinct geographical distributions. In all continents, present day isolates of H. pylori have molecular markers that refl ect population migrations. The colonization of the Americas as well as the slave trade introduced European and African strains to the New World. The relationship between H. pylori genome and gastric cancer rates is linked to the presence of the cagA gene, but the knowledge on this subject is incomplete because other genes may be involved in certain populations. A new situation for Homo sapiens is the absence of H. pylori colonization in certain, mostly affluent, populations, apparently brought about by improved home sanitation and widespread use of antibiotics during the last decades. The disappearance of H. pylori from the human microbiota may be linked to emerging epidemics of esophageal adenocarcinoma, some allergic diseases such as asthma and some autoimmune disorders.

참고문헌 (71)

  1. Helicobacter and Cancer Collaborative Group, "Gastric cancer and Helicobacter pylori: a combined analysis of 12 case control studies nested within prospective cohorts", Gut, 49, pp.347~353 (2001)
  2. Peek RM Jr, "Helicobacter infection and gastric neoplasia", J Pathol, 208, pp.233~248 (2006)
  3. Piazuelo MB, "Gastric cancer: an infectious disease", Infect Dis Clin North Am, 24, pp.853~869 (2010)
  4. Uemura N, "Helicobacter pylori infection and the development of gastric cancer", N Engl J Med, 345, pp.784~789 (2001)
  5. Blaser MJ, "Woodward Award: global warming and the human stomach: microecology follows macroecology", Trans Am Clin Climatol Assoc, 116, pp.65~75 (2005)
  6. Linz B, "An African origin for the intimate association between humans and Helicobacter pylori", Nature, 445, pp.915~918 (2007)
  7. Israel DA, "Helicobacter pylori genetic diversity within the gastric niche of a single human host", Proc Natl Acad Sci U S A, 98, pp.14625~14630 (2001)
  8. Kennemann L, "Helicobacter pylori genome evolution during human infection", Proc Natl Acad Sci U S A, 108, pp.5033~5038 (2011)
  9. Kersulyte D, "Emergence of recombinant strains of Helicobacter pylori during human infection", Mol Microbiol, 31, pp.31~43 (1999)
  10. Salama N, "A whole-genome microarray reveals genetic diversity among Helicobacter pylori strains", Proc Natl Acad Sci U S A, 97, pp.14668~14673 (2000)
  11. Suerbaum S, "Helicobacter pylori evolution and phenotypic diversification in a changing host", Nat Rev Microbiol, 5, pp.441~452 (2007)
  12. Ferlay J, "Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008", Int J Cancer, 127, pp.2893~2917 (2010)
  13. International Agency for Research on Cancer, "Monographs on the evaluation of carcinogenic risks to humans. Volume 61. Schistosomes, liver flukes and Helicobacter pylori", pp.177~240 (1994), IARC Press
  14. Parkin DM, "The global health burden of infection-associated cancers in the year 2002", Int J Cancer, 118, pp.3030~3044 (2006)
  15. "GLOBOCAN 2008. Cancer Incidence and Mortality Worldwide in 2008" (2010)[URL]
  16. Holcombe C, "Helicobacter pylori : the African enigma", Gut, 33, pp.429~431 (1992)
  17. Correa P, "Review article: antioxidant micronutrients and gastric cancer", Aliment Pharmacol Ther, 12(Suppl 1), pp.73~82 (1998)
  18. Fox JG, "The African enigma: the parasite’s perspective", Gut, 49, pp.156~157 (2001)
  19. Whary MT, "Intestinal helminthiasis in Colombian children promotes a Th2 response to Helicobacter pylori: possible implications for gastric carcinogenesis", Cancer Epidemiol Biomarkers Prev, 14, pp.1464~1469 (2005)
  20. Blaser MJ, "Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach", Cancer Res, 55, pp.2111~2115 (1995)
  21. Parsonnet J, "Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection", Gut, 40, pp.297~301 (1997)
  22. Censini S, "cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors", Proc Natl Acad Sci U S A, 93, pp.14648~14653 (1996)
  23. Covacci A, "Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer", Proc Natl Acad Sci U S A, 90, pp.5791~5795 (1993)
  24. Hatakeyama M, "Helicobacter pylori and gastric carcinogenesis", J Gastroenterol, 44, pp.239~248 (2009)
  25. Wroblewski LE, "Helicobacter pylori and gastric cancer: factors that modulate disease risk", Clin Microbiol Rev, 23, pp.713~739 (2010)
  26. Covacci A, "Helicobacter pylori virulence and genetic geography", Science, 284, pp.1328~1333 (1999)
  27. Hatakeyama M, "Anthropological and clinical implications for the structural diversity of the Helicobacter pylori CagA oncoprotein", Cancer Sci, 102, pp.36~43 (2011)
  28. Figura N, "cagA positive and negative Helicobacter pylori strains are simultaneously present in the stomach of most patients with non-ulcer dyspepsia: relevance to histological damage", Gut, 42, pp.772~778 (1998)
  29. Higashi H, "Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites", Proc Natl Acad Sci U S A, 99, pp.14428~14433 (2002)
  30. Miura M, "Differential oncogenic potential of geographically distinct Helicobacter pylori CagA isoforms in mice", Int J Cancer, 125, pp.2497~2504 (2009)
  31. Naito M, "Influence of EPIYA-repeat polymorphism on the phosphorylation-dependent biological activity of Helicobacter pylori CagA", Gastroenterology, 130, pp.1181~1190 (2006)
  32. Sicinschi LA, "CagA C-terminal variations in Helicobacter pylori strains from Colombian patients with gastric precancerous lesions", Clin Microbiol Infect, 16, pp.369~378 (2010)
  33. Atherton JC, "Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration", J Biol Chem, 270, pp.17771~17777 (1995)
  34. Cover TL, "Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains", J Biol Chem, 269, pp.10566~10573 (1994)
  35. Atherton JC, "Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori", Gastroenterology, 112, pp.92~99 (1997)
  36. Miehlke S, "The Helicobacter pylori vacA s1, m1 genotype and cagA is associated with gastric carcinoma in Germany", Int J Cancer, 87, pp.322~327 (2000)
  37. van Doorn LJ, "Geographic distribution of vacA allelic types of Helicobacter pylori", Gastroenterology, 116, pp.823~830 (1999)
  38. Rhead JL, "A new Helicobacter pylori vacuolating cytotoxin determinant, the intermediate region, is associated with gastric cancer", Gastroenterology, 133, pp.926~936 (2007)
  39. Macaulay V, "Single, rapid coastal settlement of Asia revealed by analysis of complete mitochondrial genomes", Science, 308, pp.1034~1036 (2005)
  40. Pope KO, "Environmental setting of human migrations in the circum-Pacific region", J Biogeogr, 35, pp.1~21 (2008)
  41. Moodley Y, "The peopling of the Pacific from a bacterial perspective", Science, 323, pp.527~530 (2009)
  42. Wirth T, "Distinguishing human ethnic groups by means of sequences from Helicobacter pylori: lessons from Ladakh", Proc Natl Acad Sci U S A, 101, pp.4746~4751 (2004)
  43. Falush D, "Traces of human migrations in Helicobacter pylori populations", Science, 299, pp.1582~1585 (2003)
  44. Correa P, "Gastric cancer: two epidemics?", Dig Dis Sci, 56, pp.1585~1586 (2011)
  45. Furuta Y, "Evolution of cagA oncogene of Helicobacter pylori through recombination", PLoS One, 6, pp.e23499~ (2011)
  46. Devi SM, "Ancestral European roots of Helicobacter pylori in India", BMC Genomics, 8, pp.184~ (2007)
  47. Breurec S, "Evolutionary history of Helicobacter pylori sequences reflect past human migrations in Southeast Asia", PLoS One, 6, pp.e22058~ (2011)
  48. Tay CY, "Population structure of Helicobacter pylori among ethnic groups in Malaysia: recent acquisition of the bacterium by the Malay population", BMC Microbiol, 9, pp.126~ (2009)
  49. Yamaoka Y, "Geographic differences in gastric cancer incidence can be explained by differences between Helicobacter pylori strains", Intern Med, 47, pp.1077~1083 (2008)
  50. Camorlinga-Ponce M, "Helicobacter pylori genotyping from American indigenous groups shows novel Amerindian vacA and cagA alleles and Asian, African and European admixture", PLoS One, 6, pp.e27212~ (2011)
  51. Domínguez-Bello MG, "Amerindian Helicobacter pylori strains go extinct, as european strains expand their host range", PLoS One, 3, pp.e3307~ (2008)
  52. Ghose C, "East Asian genotypes of Helicobacter pylori strains in Amerindians provide evidence for its ancient human carriage", Proc Natl Acad Sci U S A, 99, pp.15107~15111 (2002)
  53. Yamaoka Y, "Helicobacter pylori in North and South America before Columbus", FEBS Lett, 517, pp.180~184 (2002)
  54. Wang S, "Genetic variation and population structure in native Americans", PLoS Genet, 3, pp.e185~ (2007)
  55. Wang S, "Geographic patterns of genome admixture in Latin American Mestizos", PLoS Genet, 4, pp.e1000037~ (2008)
  56. Segal I, "Helicobacter pylori: an African perspective", QJM, 94, pp.561~565 (2001)
  57. Fage JD, "Slavery and the slave trade in the context of West African history", J Afr Hist, 10, pp.393~404 (1969)
  58. Salas A, "The African diaspora: mitochondrial DNA and the Atlantic slave trade", Am J Hum Genet, 74, pp.454~465 (2004)
  59. Kersulyte D, "Helicobacter pylori from Peruvian amerindians: traces of human migrations in strains from remote Amazon, and genome sequence of an Amerind strain", PLoS One, 5, pp.e15076~ (2010)
  60. Mane SP, "Host-interactive genes in Amerindian Helicobacter pylori diverge from their Old World homologs and mediate inflammatory responses", J Bacteriol, 192, pp.3078~3092 (2010)
  61. Suzuki M, "Attenuated CagA oncoprotein in Helicobacter pylori from Amerindians in Peruvian Amazon", J Biol Chem, 286, pp.29964~29972 (2011)
  62. Bravo LE, "Virulence-associated genotypes of Helicobacter pylori: do they explain the African enigma?", Am J Gastroenterol, 97, pp.2839~2842 (2002)
  63. de Sablet T, "Phylogeographic origin of Helicobacter pylori is a determinant of gastric cancer risk", Gut, 60, pp.1189~1195 (2011)
  64. "Surveillasnce Epidemiology and End Results (SEER) Cancer Statistics Review, 1975-2008" (2011)[URL]
  65. Epplein M, "Race, African ancestry, and Helicobacter pylori infection in a low-income United States population", Cancer Epidemiol Biomarkers Prev, 20, pp.826~834 (2011)
  66. Sonnenberg A, "Differences in the birth-cohort patterns of gastric cancer and peptic ulcer", Gut, 59, pp.736~743 (2010)
  67. Sonnenberg A, "Time trends of mortality from gastric cancer in Europe", Dig Dis Sci, 56, pp.1112~1118 (2011)
  68. Aragonés N, "Time trend and ageperiod-cohort effects on gastric cancer incidence in Zaragoza and Navarre, Spain", J Epidemiol Community Health, 51, pp.412~417 (1997)
  69. Anderson WF, "Age-specific trends in incidence of noncardia gastric cancer in US adults", Jama, 303, pp.1723~1728 (2010)
  70. Strachan DP, "Hay fever, hygiene, and household size", BMJ, 299, pp.1259~1260 (1989)
  71. Arnold IC, "Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells", J Clin Invest, 121, pp.3088~3093 (2011)

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