피부 가려움증에 대한 大豆 발효물(Bio-Peptone)크림의 유효성 평가 : 무작위 배정, 양측 눈가림, 위약크림 대조, 평행 설계 연구
Evaluate efficacy of fermented soybean(Bio-Peptone)cream in pruritus : Randomized, double-blinded, placebo-controlled, parallel-group clinical experiment study
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objectives : The authors conducted randomized, Double-blinded, and placebo-controlled parallel-group clinical experiment study to evaluate efficacy of fermented soybean(Bio-Peptone)cream in pruritus. Methods : The research had been conducted for 4 months from the date of IRB approval(May 26 in 2017) to Sept 2017. The experiment started by randomly distributing 25 subjects with pruritus into experimental group and control group, respectively. The experimental group applied fermented soybean(Bio-Peptone)cream twice a day, in the morning and evening, for one week on itchy area. The effect of the product was evaluated by comparing the PSS(Patient subjective score), moisture level by measuring skin moisture content(Corneometer) and transepidermal water loss(Tewameter), and the Korean version of Skindex-29(index of quality of life improvement) before applying the cream, after applying the cream for one week and after stop applying the cream for one week. The control group conducted identical experiment with the experimental group, except the control group applied placebo instead of the fermented soybean(Bio-Peptone)cream. Results : Pruritus, criterion of the first validation testing, indicates fermented soybean(Bio-Peptone)cream tend to reduce pruritus compare to placebo, although the result is not statistically noticeable. Significant difference in reduction of prutitus, the second validation test was not discovered in both groups. Corneometer and life quality tend to be improved with soy cream than placebo, but not statistically effective and both groups did not show any difference in terms of Tewameter measurement. Conclusions : The result of clinical experiment didn’t prove that the fermented soybean(Bio-Peptone)cream is more effective in reducing pruritus than placebo, statistically. The clinical use of soybean product for pruritus requires further studies to be verified.
Abstract
Objectives : The authors conducted randomized, Double-blinded, and placebo-controlled parallel-group clinical experiment study to evaluate efficacy of fermented soybean(Bio-Peptone)cream in pruritus. Methods : The research had been conducted for 4 months from the date of IRB approval(May 26 in 2017) to Sept 2017. The experiment started by randomly distributing 25 subjects with pruritus into experimental group and control group, respectively. The experimental group applied fermented soybean(Bio-Peptone)cream twice a day, in the morning and evening, for one week on itchy area. The effect of the product was evaluated by comparing the PSS(Patient subjective score), moisture level by measuring skin moisture content(Corneometer) and transepidermal water loss(Tewameter), and the Korean version of Skindex-29(index of quality of life improvement) before applying the cream, after applying the cream for one week and after stop applying the cream for one week. The control group conducted identical experiment with the experimental group, except the control group applied placebo instead of the fermented soybean(Bio-Peptone)cream. Results : Pruritus, criterion of the first validation testing, indicates fermented soybean(Bio-Peptone)cream tend to reduce pruritus compare to placebo, although the result is not statistically noticeable. Significant difference in reduction of prutitus, the second validation test was not discovered in both groups. Corneometer and life quality tend to be improved with soy cream than placebo, but not statistically effective and both groups did not show any difference in terms of Tewameter measurement. Conclusions : The result of clinical experiment didn’t prove that the fermented soybean(Bio-Peptone)cream is more effective in reducing pruritus than placebo, statistically. The clinical use of soybean product for pruritus requires further studies to be verified.
참고문헌 (27)
- 목지예, "렛트 복강 비만세포와 화학항원 유도 알레르기 마우스에서 황금과 금은화 추출물의 항가려움 및 항염증 상승효과", 동의생리병리학회지, 27(1), pp.83~91 (2013), 한의병리학회
- Kang H, "The compilation committee of Korean dermatology textbook", pp.108~ (2014), Korean medicine
- 임현정, "전신가려움증에 대한 임상적 고찰", 대한피부과학회지, 47(11), pp.1246~1252 (2009), 대한피부과학회
- Kim IL, "The herbal medicine textbook", pp.736~ (2010), yeonglim-sa
- Park SW, "Preventive and Healing Effects of Anthocyanin from Black Soybean Seed Coat on Radiation-Induced Skin Injury", pp.2017
- Kim BB, "Inhibitory effects of 7,3',4'-trihydroxyisoflavone on the development of atopic dermatitis-like skin lesions in NC", Nga mice, Department of Applied Life Sciences Graduate School Kyungpook National University, 2013
- Moon SH, "Anti-aging effects of enzymatically modified soybean extract in the Human Fibroblast cells", Department of Chemical Engineering, pp.2013
- Park JS, "New Oxyisoflavone Derivatives From Fermented Soybean And Their Biological Activity", Department of Oriental Medicine, pp.2012
- 김성열, "Bacillus sp.에 의하여 발효된 신품종 아가콩 발효 산물의 혈전 용해 활성 및 항산화 효과", 생명과학회지, 20(11), pp.1711~1717 (2010), 한국생명과학회
- 박준성, "전통 콩발효 식품 유래 7, 8, 4'-Trihydroxyisoflavone의 피부 생리활성 연구", 대한화장품학회지, 36(3), pp.221~226 (2010), 사단법인 대한화장품학회
- 정재남, "한약재 추출물 및 대두분획물(LES)이 피부세포에서 노화관련 유전자 발현에 미치는 영향 및 Multiplex-PCR 활용한 효능분석법 개발", 석사, 동물학, pp.2010
- Lee YS, "Effects of Soybean Fermented Extract Glyceollins on Skin Whitening", Department of Biochemistry, pp.2010
- Lee KH, "Antioxidative Properties of Isoflavone, Genistein from Soybean and Its Application to Whitening Cosmetics", Department of Industry, pp.2003
- Kim SH, "Components responsible for antioxidative activity in black soybean", Department of Food and Life Sciences, pp.2002
- 김정숙, "대두 추출물 LES가 DNCB로 유도된 랫드의 알레르기성 접촉피부염에 미치는 영향", 생명과학회지, 21(5), pp.713~719 (2011), 한국생명과학회
- Park HB, "Antiapoptotic and antiinflammatory actions of anthocyanins obtained from black soybean", Department of Medicine, pp.2007
- Lee JS, "Soybean extracts and its impact on skin aging", J of Beauty Industry, 5(1), pp.1~8 (2014)
- Jeon KM, "Anti-wrinkle and Whitening Effects of Cosmetics Using Black Soybean Powder on Skin Care", Department of Public Health, pp.2011
- Jin HN, "Effect of black soybean supplement on young Women's skin condition", Department of Lifetime Welfare, pp.2013
- Son YH, "Effects of Yellow Soybeans on skin", Department of Industry, pp.2005
- 김은주, "대두 발효물(Bio-Peptone®)의 광노화 억제 효과", 대한화장품학회지, 45(1), pp.27~36 (2019), 사단법인 대한화장품학회[DOI]
- 유영경, "건조 피부와 피부 가려움 개선에 도움을 주는 보습 크림의 효능 및 안전성 연구", 아시안뷰티화장품학술지, 13(1), pp.49~57 (2015), 한국피부과학연구원
- Song JW, "A Morphologic Study of the Structural Change", The Korean J of Pathology, 92(4), pp.349~361 (1993)
- 류승희, "노란콩 및 검정콩의 섭취가 흰쥐의 항산화 및 항노화 시스템에 미치는 영향", 한국식품영양과학회지, 32(4), pp.591~597 (2003), 한국식품영양과학회
- Matsuda A, "Supplementation of the fermented soy product ImmuBalance™effectively reduces itching behavior of atopic NC", Tnd mice, 2012, pp.67(2), 130~139
- Alam M, "Effect of Platelet-Rich Plasma Injection for Rejuvenation of Photoaged Facial Skin A Randomized Clinical Trial", JAMA Dermatol, 154(12), pp.1447~1452 (2018)
- Armstrong AW, "Improvement in Patient-Reported Outcomes(Dermatology Life Quality Index and the Psoriasis Symptoms and Signs Diary)with Guselkumab in Moderate-to-Severe Plaqe Psoriasis : Results from the Phase III VOYAGE 1 and VOYAGE 2 Studies", Am J Clin Dermatol, 20(1), pp.155~164 (2019)