Effect of Emollients Containing Vegetable-Derived Lactobacillus in the Treatment of Atopic Dermatitis Symptoms: Split-Body Clinical Trial
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Background: Atopic dermatitis (AD) patients suffer fromxerosis. Proper skin care, including the use of emollients,may help improve xerosis and minimize disease exacerbation. Lactobacillus sakei probio 65, isolated from theKorean vegetable-based product kimchi, can decreaseinterleukin 4 and immunoglobulin E levels and inhibitStaphylococcus aureus. Moreover, it has reportedly shownpositive dermatological effects in both animal and clinicalstudies. Objective: To compare the effects of an emollientthat contains Lactobacillus (treated) with a normal emollient(control) on AD. Methods: This double-blind, randomized,split-body clinical trial involved 28 patients with AD. Thepatients applied the Lactobacillus-containing emollient onone side of their body and the control emollient on the otherside twice daily for 4 weeks. Trans-epidermal water loss(TEWL) and skin capacitance were evaluated and investigatorglobal assessment and the visual analogue scale(VAS) were administered on weeks 0, 1, 2, and 4. Results:The treated sides had significantly lower TEWL and VASvalues and significantly higher skin capacitance values overtime than the control sides. Conclusion: Topical applicationof Lactobacillus-containing emollients may improve the skinpermeability of patients with AD.
Abstract
Background: Atopic dermatitis (AD) patients suffer fromxerosis. Proper skin care, including the use of emollients,may help improve xerosis and minimize disease exacerbation. Lactobacillus sakei probio 65, isolated from theKorean vegetable-based product kimchi, can decreaseinterleukin 4 and immunoglobulin E levels and inhibitStaphylococcus aureus. Moreover, it has reportedly shownpositive dermatological effects in both animal and clinicalstudies. Objective: To compare the effects of an emollientthat contains Lactobacillus (treated) with a normal emollient(control) on AD. Methods: This double-blind, randomized,split-body clinical trial involved 28 patients with AD. Thepatients applied the Lactobacillus-containing emollient onone side of their body and the control emollient on the otherside twice daily for 4 weeks. Trans-epidermal water loss(TEWL) and skin capacitance were evaluated and investigatorglobal assessment and the visual analogue scale(VAS) were administered on weeks 0, 1, 2, and 4. Results:The treated sides had significantly lower TEWL and VASvalues and significantly higher skin capacitance values overtime than the control sides. Conclusion: Topical applicationof Lactobacillus-containing emollients may improve the skinpermeability of patients with AD.
참고문헌 (20)
- Leung DY, "Atopic dermatitis", Lancet, 361, pp.151~160 (2003)
- Leung DY, "Disease management of atopic dermatitis:a practice parameter. Joint Task Force on Practice Parameters, representing the American Academy of Allergy, Asthma and Immunology, the American College of Allergy, Asthma and Immunology, and the Joint Council of Allergy, Asthma and Immunology. Work Group on Atopic Dermatitis", Ann Allergy Asthma Immunol, 79, pp.197~211 (1997)
- Hanifin JM, "Guidelines of care for atopic dermatitis, developed in accordance with the American Academy of Dermatology (AAD)", American Academy of Dermatology Association "Administrative Regulations for Evidence-Based Clinical Practice Guidelines", 2004, pp.50, 391~404
- Lucky AW, "Use of an emollient as a steroid-sparing agent in the treatment of mild to moderate atopic dermatitis in children", Pediatr Dermatol, 14, pp.321~324 (1997)
- Szczepanowska J, "Emollients improve treatment results with topical corticosteroids in childhood atopic dermatitis: a randomized comparative study", Pediatr Allergy Immunol, 19, pp.614~618 (2008)
- Simpson EL, "A pilot study of emollient therapy for the primary prevention of atopic dermatitis", J Am Acad Dermatol, 63, pp.587~593 (2010)
- Charman CR, "Topical corticosteroid phobia in patients with atopic eczema", Br J Dermatol, 142, pp.931~936 (2000)
- Joo SS, "Therapeutic advantages of medicinal herbs fermented with Lactobacillus plantarum, in topical application and its activities on atopic dermatitis", Phytother Res, 23, pp.913~919 (2009)
- Segawa S, "Probiotic-derived polyphosphate enhances the epithelial barrier function and maintains intestinal homeostasis through integrin-p38 MAPK pathway", PLoS One, 6, pp.e23278~ (2011)
- 박천욱, "New Functional Probiotic Lactobacillus sakei Probio 65 Alleviates Atopic Symptoms in the Mouse", Journal of Medicinal Food, 11(3), pp.405~412 (2008), 한국식품영양과학회
- Woo SI, "Effect of Lactobacillus sakei supplementation in children with atopic eczema-dermatitis syndrome", Ann Allergy Asthma Immunol, 104, pp.343~348 (2010)
- Hanifin JM, "Diagnostic features of atopic dermatitis", Acta Derm Venereol, 92, pp.44~47 (1980)
- Smits HH, "Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin", J Allergy Clin Immunol, 115, pp.1260~1267 (2005)
- Hoarau C, "Supernatant of Bifidobacterium breve induces dendritic cell maturation, activation, and survival through a Tolllike receptor 2 pathway", J Allergy Clin Immunol, 117, pp.696~702 (2006)
- Isolauri E, "Lactobacillus casei strain GG reverses increased intestinal permeability induced by cow milk in suckling rats", Gastroenterology, 105, pp.1643~1650 (1993)
- Rosenfeldt V, "Effect of probiotics on gastrointestinal symptoms and small intestinal permeability in children with atopic dermatitis", J Pediatr, 145, pp.612~616 (2004)
- van der Aa LB, "Probiotics and prebiotics in atopic dermatitis:review of the theoretical background and clinical evidence", Pediatr Allergy Immunol, 21, pp.e355~e367 (2010)
- Valdéz JC, "Interference of Lactobacillus plantarum with Pseudomonas aeruginosa in vitro and in infected burns: the potential use of probiotics in wound treatment", Clin Microbiol Infect, 11, pp.472~479 (2005)
- Peral MC, "Bacteriotherapy with Lactobacillus plantarum in burns", Int Wound J, 6, pp.73~81 (2009)
- Huang JT, "Treatment of Staphylococcus aureus colonization in atopic dermatitis decreases disease severity", Pediatrics, 123, pp.e808~e814 (2009)