본문 바로가기
KERD
논문KCI 등재

알레르기 비염에 대한 小靑龍湯의 효과 평가 연구 : 체계적 문헌고찰과 메타분석

A Study on Effectiveness of Socheongryong-tang for Allergic Rhinitis : A Systematic Review and Meta-analysis

이동효|강정인|신선호|민경진
대한한방안이비인후피부과학회 (The Korean Medicine Opthalmology&Otolaryngology&Dermatology Society)|2020.11|한방안이비인후피부과학회지 (The Journal of Korean Medicine Ophthalmology&Otorhinolaryngology&Dermatology)|제33권 제4호|pp. 74-99|DOI http://dx.doi.org/10.6114/jkood.2020.33.4.074

2

조회

0

다운로드

3

인용

0

참고문헌

키워드

Systematic ReviewMeta-analysisAllergic RhinitisRandomized controlled trialsSocheongryong-tang(Xiaoqinglong-tang)
주제분류한의학

초록

Objectives : The purpose of this study is to assess the effectiveness and safety of Socheongryong-tang(SCRT) for allergic rhinitis(AR). Methods : We searched randomized controlled trials(RCTs) that used SCRT for AR in 8 databases(PubMed, Cochrane Library, CNKI, CiNii Articles, OASIS, NDSL, KISS, KMbase) from their inception until August 2019. The primary outcome was effective rate and scores evaluating the improvement of AR symptoms. The secondary outcome was quality of life scale, adverse events, recurrence rate, and laboratory indicators. Two researchers assessed the risk of bias in the included trials through the Cochrane Risk of Bias tool independently. The study synthesized outcomes using RevMan 5.3. Results : Eighteen RCTs involving 1686 participants were included in this review. The risk of bias was unclear for the majority of the included studies. Meta-analysis of 12 RCTs showed that there was no statistically significant difference between the SCRT group and usual care group in the effective rate(RR 1.18, 95% CI(0.98, 1.41), p=0.09, I2=46%). Meta-analysis of 5 RCTs showed that the combination treatment group of SCRT and usual care was significantly higher than the usual care group in the effective rate(RR 1.24, 95% CI(1.12, 1.38), p<0.0001, I2=0%). The SCRT group was more effective in improving nasal symptoms and quality of life than the placebo group according to one RCT. Mild adverse events such as dry mouth were identified in 5 RCTs, but no serious adverse events were reported. Conclusion : This review showed that in terms of the effective rate for AR, there was no statistically significant difference between SCRT and usual care and the combination treatment of SCRT and usual care was more effective than usual care. There were no serious adverse events. However, it is difficult to make a definite conclusion because of few included studies and heterogeneity between studies, and the quality of included studies was mostly insufficient. Further well-designed randomized controlled trials are needed.

Abstract

Objectives : The purpose of this study is to assess the effectiveness and safety of Socheongryong-tang(SCRT) for allergic rhinitis(AR). Methods : We searched randomized controlled trials(RCTs) that used SCRT for AR in 8 databases(PubMed, Cochrane Library, CNKI, CiNii Articles, OASIS, NDSL, KISS, KMbase) from their inception until August 2019. The primary outcome was effective rate and scores evaluating the improvement of AR symptoms. The secondary outcome was quality of life scale, adverse events, recurrence rate, and laboratory indicators. Two researchers assessed the risk of bias in the included trials through the Cochrane Risk of Bias tool independently. The study synthesized outcomes using RevMan 5.3. Results : Eighteen RCTs involving 1686 participants were included in this review. The risk of bias was unclear for the majority of the included studies. Meta-analysis of 12 RCTs showed that there was no statistically significant difference between the SCRT group and usual care group in the effective rate(RR 1.18, 95% CI(0.98, 1.41), p=0.09, I2=46%). Meta-analysis of 5 RCTs showed that the combination treatment group of SCRT and usual care was significantly higher than the usual care group in the effective rate(RR 1.24, 95% CI(1.12, 1.38), p<0.0001, I2=0%). The SCRT group was more effective in improving nasal symptoms and quality of life than the placebo group according to one RCT. Mild adverse events such as dry mouth were identified in 5 RCTs, but no serious adverse events were reported. Conclusion : This review showed that in terms of the effective rate for AR, there was no statistically significant difference between SCRT and usual care and the combination treatment of SCRT and usual care was more effective than usual care. There were no serious adverse events. However, it is difficult to make a definite conclusion because of few included studies and heterogeneity between studies, and the quality of included studies was mostly insufficient. Further well-designed randomized controlled trials are needed.

참고문헌 (42)

  1. Bousquet J, "Togias A, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008", Allergy, 63(Suppl. 86), pp.8~160 (2008)
  2. Bousquet J, "Allergic rhinitis and its impact on asthma", J Allergy Clin Immunol, 108(Suppl. 5), pp.S147~S334 (2001)
  3. Brozek JL, "Allergic Rhinitis and its Impact on Asthma(ARIA)guidelines : 2010 revision", J Allergy Clin Immunol, 126, pp.466~476 (2010)
  4. "Korean Statistical Information Service" (2019)[URL]
  5. Juniper EF, "Quality of life in adults and children with asthma and rhinitis", Allergy, 52(10), pp.971~977 (1997)
  6. Canonica GW, "The impact of allergic rhinitis on quality of life and other airway diseases", Allergy, 53(Suppl. 41), pp.7~30 (1998)
  7. University of Michigan Health System(UMHS)Allergic Rhinitis Guideline, "David AD", University of Michigan, 1~17 (2013)
  8. Rapiejko P, "Treatment strategy of allergic rhinitis in the face of modern world threats", Otolaryngol Pol, 72(2), pp.1~12 (2018)
  9. Seidman MD, "Clinical practice guideline: Allergic rhinitis", OTO Open, 152(1_Suppl), pp.S1~S43 (2015)
  10. Yonekura S, "Complementary and alternative medicine for allergic rhinitis in Japan", Allergol Int, 66(3), pp.425~431 (2017)
  11. Xue CC, "Treatment for seasonal allergic rhinitis by Chinese herbal medicine : a randomized placebo controlled trial", Altern Ther Health Med, 9, pp.80~87 (2003)
  12. Hu G, "The Chinese herbal formulation biminne in management of perennial allergic rhinitis : a randomized, double-blind, placebo-controlled, 12-week clinical trial", Ann Allergy Asthma Immunol, 88, pp.478~487 (2002)
  13. Kim MH, "A multicenter study on the efficacy and safety of So-Cheong-Ryong-Tang for perennial allergic rhinitis", Complement Ther Med, 45, pp.50~56 (2019)
  14. Ng DK, "A double-blind, randomized, placebo-controlled trial of acupuncture for the treatment of childhood persistent allergic rhinitis", Pediatrics, 114, pp.1242~1247 (2004)
  15. 김영은, "알레르기 비염의 한의 진료 현황 설문조사", 한방안이비인후피부과학회지, 30(4), pp.75~96 (2017), 대한한방안이비인후피부과학회[DOI]
  16. Korean Medicine Encyclopedia Compilation Committee, "Korean Medicine Encyclopedia" (2001), Jeongdam Books
  17. Kim MH, "Efficacy and safety of So-Cheong-Ryong-tang in treatment of perennial allergic rhinitis : study protocol for a double-blind, randomised, parallel-group, multicentre trial", BMJ Open, 7(9), pp.e016556~ (2017)
  18. 김일환, "난알부민 유도 알레르기 비염 마우스에 대한 소청룡탕(小靑龍湯)의 효능 실험연구", 대한예방한의학회지, 18(3), pp.69~80 (2014), 대한예방한의학회
  19. Wang B, "Meta-analysis of Xiaoqinglong Decoction in Treating Allergic Rhinitis", China Journal of Chinese Medicine, 30, pp.665~667 (2015)
  20. 강현, "메타분석에서 통계학적 고려사항들", Hanyang Medical Reviews, 35(1), pp.23~32 (2015), 한양대학교 의과대학[DOI]
  21. Otolaryngology Branch of Chinese Medical Association, "Attachment: Diagnostic criteria and efficacy evaluation criteria for allergic rhinitis (revised in 1997, Haikou)", Chin J Otorhinolaryngol, 33(3), pp.134~135 (1998)
  22. Zhu ZM, "Modified Xiaoqinglong decoction for allergic rhinitis", Hubei Journal of TCM, 26(5), pp.38~39 (2004)
  23. Jin DW, "Observation on therapeutic effect of Xiaoqinglong decoction combined with zinc gluconate on 15 cases of allergic rhinitis", Inner Mongolia Journal of Traditional Chinese Medicine, 6, pp.31~ (2010)
  24. Chen P, "The effect of Xiaoqinglong decoction on eosinophils in nasal secretion and serum IL-4 in patients with allergic rhinitis", Journal of New Chinese Medicine, 42(11), pp.58~60 (2010)
  25. Chi LP, "Observation on therapeutic effect of Xiaoqinglong decoction combined with acupuncture-moxibustion therapy on 30cases of allergic rhinitis", J Pract Tradit Chin Med, 28(7), pp.544~545 (2012)
  26. Chen P, "Xiaoqinglong decoction combined with nasal fumigation for 53 cases of allergic rhinitis", Henan Traditional Chinese Medicine, 32(11), pp.1433~1435 (2012)
  27. Liu Z, "Observation on therapeutic effect of modified Xiaoqinglong decoction combined with acupoint application for allergic rhinitis", Journal of North Pharmacy, 11(2), pp.24~25 (2014)
  28. Li XR, "Efficacy of Xiao-qing-long-tang in Treatment of Allergic Rhinitis with Lung-qi Deficiency and Cold Syndrome", Journal of Chengdu Medical College, 6, pp.696~699 (2015)
  29. Zhang AP, "Clinical study on the TCM syndrome differentiation law of allergic rhinitis and modified Xiaoqinglong decoction", Chinese and Foreign Medical Research, 14(34), pp.106~108 (2016)
  30. Du EG, "Clinical effect of the Xiaoqinglong decoction on allergic rhinitis of the Feiqi Xuhan type", Clinical Journal of Chinese Medicine, 9(36), pp.42~44 (2017)
  31. Chen DF, "Analysis of clinical effect of"five steps of differentiating Yang Deficiency"and"Xiaoqinglong decoction with Pulvis Aconiti Tuberis"in treating allergic rhinitis", China Prac Med, 12(14), pp.128~129 (2017)
  32. Wang CQ, "Therapeutic effect of Xiao Qing Long decoction on allergic rhinitis", Medical Information, 31(4), pp.141~142 (2018)
  33. Xu L, "The effect of Xiaoqinglong decoction for allergic rhinitis", Chin Med J Metall Indus, 35(3), pp.332~333 (2018)
  34. Li YJ, "The clinical obsevation on 42 cases of allergic rhinitis and asthma treated with modified Xiaoqinglong decoction", Hebei Medicine, 11(6), pp.560~562 (2005)
  35. Zhu M, "Observation on the effect of Xiaoqinglong mixture in adjuvant treatment of allergic rhinitis in children", Journal of Pediatric Pharmacy, 17(6), pp.60~ (2011)
  36. Chai BX, "Modified Xiaoqinglong decoction for the treatment of 18 cases of allergic rhinitis", Shandong Journal of Traditional Chinese Medicine, 32(9), pp.636~637 (2013)
  37. Zhang ZM, "The clinical research into allergic rhinitis treated with Xiao Qinglong decoction", Henan Traditional Chinese Medicine, 35(8), pp.1743~1745 (2015)
  38. Wu ZM, "Observation on therapeutic effect of combination of Traditional Chinese Medicine with Western Medicine on allergic rhinitis", Journal of New Chinese Medicine, 47(12), pp.173~174 (2015)
  39. "Healthcare Bigdata Hub" (2019)[URL]
  40. "Complementary and alternative therapies for allergic rhinitis and conjunctivitis" (2018)[URL]
  41. Herbal Formula Science Professors, College of Korean Medicine, "Herbal Formula Science" (2003), Younglim Books
  42. Higgins JP, "Measuring inconsistency in metaanalyses", BMJ, 327(7414), pp.557~560 (2003)

관련 논문AI추천

알레르기성 비염에 대한 한약 및 양약 국소비강외용제의 효과 비교 : 체계적 문헌 고찰김선혜, 김은정, 성원석, 오세희, 조효림, 홍승욱대한한방안이비인후피부과학회 · 한방안이비인후피부과학회지2019 · 제32권 제4호국소한약외용제의 알레르기성 비염 치료 효과에 대한 문헌 고찰김장현, 민상연, 방미란대한한방소아과학회 · 대한한방소아과학회지2016 · 제30권 제3호알레르기 비염의 침 치료에 대한 체계적 고찰김경순, 김승모, 문병권, 이유리, 조나경, 최홍식대한한방내과학회 · 대한한방내과학회지2020 · 제41권 제6호난알부민 유도 알레르기 비염 마우스에 대한 소청룡탕(小靑龍湯)의 효능 실험연구고성규, 구진모, 김일환, 나창혁, 신용철, 장보형, 허한솔대한예방한의학회 · 대한예방한의학회지2014 · 제18권 제3호알레르기 비염의 한의학적 관리를 위한 최신 지견김혜화, 송민영, 정창운, 조희근대한한방안이비인후피부과학회 · 한방안이비인후피부과학회지2016 · 제29권 제4호알레르기 비염 한의표준임상진료지침 방향 제언 - 2018 중국 임상진료지침을 바탕으로강정인, 이동효대한한방안이비인후피부과학회 · 한방안이비인후피부과학회지2019 · 제32권 제4호

이 간행물의 다른 논문 (11건)

중등도 이하 아토피 피부염에 영향을 미치는 환자 요인김윤범, 강동원pp. 1-15둔산한방병원 한방안이비인후피부과 내원 피부질환 환자 특성 분석 - 2016년 3월부터 2019년 2월까지 -정현아, 김수영pp. 16-31한국산 동백종자 초임계 추출물의 피부 항산화 및 항노화 연구곽병문, 김희택, 김이화, 김태준pp. 32-43Caffeine 및 광자극 유발 스트레스 동물모델에서 구기자 복합물이 스트레스 완화 및 혈중 멜라토닌에 미치는 영향김이화, 김희택, 김용민, 황동석pp. 44-54알레르기 비염의 비강 내 광 치료 : 체계적 문헌고찰민경진, 이동효, 강정인pp. 55-73
원문 보기