Mouse cell에서 托裏消毒飮의 항산화작용과 항염증 효과
The Effects of Taglisodog-eum Extract on Antioxidant and Antiinflammatory ability in mouse cell
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Abstract
Background and Objectives : The aim of this study was to investigate the anti-oxidant and anti-inflammatory effects of the Taglisodog-eum(TSE) extract on the RAW264.7 cell Methods : The RAW264.7 cell was cultured using Dulbecco’s modified Eagle’s medium(DMEM, USA), including the 10% fetal-bovine serum(FBS; Sigma, USA) in a 37℃, 5% CO2 incubator. Results : The anti-oxidant ability of TSE were dose-dependantly increased. The LPS-induced IKK, iNOS and COX-2 mRNA expression were dose-dependantly decreased in the RAW264.7 cells treated with TSE. NF-κB activation was suppressed. Conclusion : The findings in this study show that TSE has anti-oxidant and anti-inflammatory effects, such as the inhibition of NF-κB activity.
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