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五味消毒飮의 抗炎效果 및 機轉에 關한 實驗的硏究

Anti-inflammatory Effects of Omisodokeum

최창민|김송백|조한백|이순이|서윤정
대한한방부인과학회 (The Society Of Oriental Obstetrics & Gynecology)|2008.02|대한한방부인과학회지 (The Journal of Oriental Obstetrics ＆ Gynecology)|제21권 제1호|pp. 39-54

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참고문헌

주제분류한의학

초록

Abstract

Purpose: The purpose of this study was to investigate the anti-inflammatory effects of the water extract of Omisodokeum (OMSDE) on peritoneal macrophages. Methods: To verify the anti-inflammatory mechanism of OMSDE, the activation of nuclear factor-κB (NF-κB) and the phosphorylation of MAPK were examined. Results: The extract of OMSDE suppressed the production of LPS-induced nitric oxide (NO), tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6 and IL-12 in the macrophages. OMSDE inhibited the degradation of inhibitory κB-α (IκB-α) and it suppressed the activation of extracellular signal-regulated kinase (ERK 1/2) but didn't inhibit c-Jun N-terminal kinase (JNK) and p38, indicating that OMSDE may inhibit the pro-inflammatory cytokine production process by inhibiting the activation of NF-κB and ERK 1/2. Furthermore, OMSDE inhibited the production of interferon (IFN)-β but didn't inhibit of IFN-α in the LPS-stimulated macrophages through the down-regulation of interferon regulatory factor (IRF)-1 and IRF-7. The Oral administration of OMSDE inhibited LPS-induced endotoxin shock and the production of TNF-α in serum but didn't inhibit of IL-1β and IL-6. Conclusion: These results suggest that OMSDE may be effective in the prevention and treatment of inflammatory diseases.

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