홍삼과 어유(魚油) 복합식이에 의한 UV-유도 광노화 억제효과
Protective Effects of Complex Diet of Korean red ginseng and fish oil on UV-induced Photoaging
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초록
Objective : UV irradiatiion causes skin-aging involving coarse wrinkles, thickning, dyspigmentation, and roughskin surface. This study was aimed to elucidate the anti-winkle activity of complex diet of Korean red ginseng(RG) and fish oil (FO) on UV-induced Photoaging. Methods : To investigated photo-protective effects of Korean red ginseng and fish oil on UV-induced damagedskins, SKH hairless female mice were randomly divided into six groups 〔control, UV, UV/RG, UV/FO,UV/RG/FO(low), UV/RG/FO(high)〕and orally administered three times a week respectively. UV radiation wasapplied to the backs of the mice three times a week for 8 weeks. Expressions of matrix metalloproteinase(MMP)-3, MMP-13 and tissue inhibitor matrix metalloproteinase (TIMP)-1 in skin were measured byimmunohistochemical staining. Results : In this study, UVB-induced epidermal hypertropy was diminished by RG group or FO group orcomplex group of RG and FO. Expression levels of MMP-3 and MMP-13 were reduced and expression level ofTIMP-1 was increased by RG group or FO group or complex group of RG and FO. Especially MMP-3 and MMP-13were markedly reduced by diet of FO and complex diet of RG and FO compared with untreated group. Conclusions : This results suggest that complex diet of RG and FO have a anti-wrinkle activity on UV-inducedphoto-aging and intrinsic aging.
Abstract
Objective : UV irradiatiion causes skin-aging involving coarse wrinkles, thickning, dyspigmentation, and roughskin surface. This study was aimed to elucidate the anti-winkle activity of complex diet of Korean red ginseng(RG) and fish oil (FO) on UV-induced Photoaging. Methods : To investigated photo-protective effects of Korean red ginseng and fish oil on UV-induced damagedskins, SKH hairless female mice were randomly divided into six groups 〔control, UV, UV/RG, UV/FO,UV/RG/FO(low), UV/RG/FO(high)〕and orally administered three times a week respectively. UV radiation wasapplied to the backs of the mice three times a week for 8 weeks. Expressions of matrix metalloproteinase(MMP)-3, MMP-13 and tissue inhibitor matrix metalloproteinase (TIMP)-1 in skin were measured byimmunohistochemical staining. Results : In this study, UVB-induced epidermal hypertropy was diminished by RG group or FO group orcomplex group of RG and FO. Expression levels of MMP-3 and MMP-13 were reduced and expression level ofTIMP-1 was increased by RG group or FO group or complex group of RG and FO. Especially MMP-3 and MMP-13were markedly reduced by diet of FO and complex diet of RG and FO compared with untreated group. Conclusions : This results suggest that complex diet of RG and FO have a anti-wrinkle activity on UV-inducedphoto-aging and intrinsic aging.
참고문헌 (22)
- Jean LB, "Aging skin", Am J Med, 8, pp.S99~S103 (1995)
- Laure RG, "UV-light-induced signal cascades and skin aging", Ageing Res Rev, 1, pp.705~720 (2002)
- Jeroma SP, "Identification of collagen fibrils in scleroderma skin", J Invest Dermatol, 90, pp.48~54 (1998)
- Grant NH, "Studies on the collagenases of Clostridium histolyticum", Arch Biochem Biophys, 82, pp.245~255 (1959)
- Demina NS, "Collagenolytic enzymes synthesized by microorganism", Mikrobiologiia, 65, pp.293~304 (1996)
- 박시향, "자외선 조사 무모쥐 피부조직에 도포한 애엽(Mugwort) 추출물의 주름개선 효과", 한국식품영양과학회지, 37(9), pp.1136~1141 (2008), 한국식품영양과학회
- 소승호, "홍삼 생약 복합물(KTNG0345)의 피부 주름개선에 관한 작용기전", Journal of Ginseng Research, 32(1), pp.39~47 (2008), 고려인삼학회
- 이지해, "Hairless mice에서의 대두 홍삼 혼합 분말(APB-03)의 경구 반복 투여 시 피부 주름 생성 예방 효과", 한국식품과학회지, 37(6), pp.989~996 (2005), 한국식품과학회
- Choi KT, "Botanical characteristics, pharmacological effects and medical components of Korean Panax ginseng CA Meyer", Acta Pharmacol Sin, 29, pp.1109~ (2008)
- 이승호, "추출조건에 따른 홍삼추출액의 사포닌 조성 및 이화학적 특성", 한국식품영양과학회지, 37(2), pp.256~260 (2008), 한국식품영양과학회
- 최성원, "Epidermis Proliferative Effect of the Panax ginseng Ginsenoside Rb2", Archives of Pharmacal Research, 25(1), pp.71~76 (2002), 대한약학회
- Lee E. H, "Ginsenoside F1 protects human HaCaT keratinocytes from ultraviolaet-B-induced apoptosis by maintaining constant levels of Bcl-2", J Invest Dermatol, 121, pp.607~613 (2003)
- Dyerberg J, "Eicosapentaenoic acid and prevention of thrombosis and atherosclesis", Lancen, 2, pp.117~ (1978)
- Bang HO, "The composition of food consumed by Greenland Eskimos", Acta Med. Scand, 69, pp.200~ (1976)
- Bang HO, "The composition of the Eskimo food in North western Greenland", Am. J Clin Nutr, 33, pp.2657~ (1980)
- Herold PM, "Fish oil consumption and decreased risk of cardiovascular disease. A comparison of finding from animal and human feeding trials", Am J Clin Nutr, 107, pp.890~ (1986)
- Mori TA, "New findings in the fatty acid composition of individual platelet phospholipids in man after dietary fish oil supplementation", Lipids, 22, pp.744~ (1987)
- DiNicolantonio JJ, "Omega-3 polyunsaturated fatty acids for the prevention of cardiovascular disease: do formulation, dosage & comparator matter?", Mo Med, 110(6), pp.495~498 (2013)
- Fisher GJ, "Molecular basis of sun-induced premature ageing and retinoid antagonism", Nature, 379, pp.335~339 (1996)
- Vincenti MP, "Transcriptional regulation of collagenase(MMP-1, MMP-13)genes in arthritis : integration of complex signaling pathways for the recruitment of gene-specific transcription factors", Arthritis Res, 4, pp.157~164 (2002)
- Yokose U, "The endogenous protease inhibitor TIMP-1mediates protection and recovery from cutaneous photodamage", Invest. Dermatol, 132(12), pp.2800~2809 (2012)
- Vanhoutte D1, "TIMPs and cardiac remodeling : 'Embracing the MMPindependent-side of the family'", J Mol Cell Cardiol, 48(3), pp.445~453 (2010)