Ovalbumin으로 유발된 아토피피부염 모델 마우스에 대한 복합한약추출물 경구투여의 효과
Oral Administration Effects of Herbal Extracts on Atopic Dermatitis in Balb/c Mice Sensitized by Ovalbumin
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초록
Objective: This study was to evaluate whether herbal mixture (HM-A : Houttuynia cordata Thunberg, Rubuscoreanus, Rehmannia glutinosa, Prunus yedoensis, HM-B : Houttuynia cordata Thunberg, Rubus coreanus,Rehmannia glutinosa, Angelica gigas nakai) supresses the development of atopic dermatitis in Balb/c micesensitized by ovalbumin. Methods: Mice were sensitized by intraperitoneal injection of ovalbumin plus aluminum hydroxide hydrate,followed by epicutaneous sensitization for 6 weeks. After induced atopic dermatitis, HM-A and HM-B were orallyadministrated for two weeks(once a two days) as a 50 mg/kg concentration. After all mice were sacrificed at theend of the experiment, skin and blood were harvested. Results: Oral administration group was reduced the infiltration of eosinophils, mast cells and total T cells on theskin areas as well as blood analysis. Also, cutaneous expression of IL-4,13,17 decreased. Blood IgE level wasdecreased. Conclusion: These drugs could be potential candidates for the atopic dermatitis.
Abstract
Objective: This study was to evaluate whether herbal mixture (HM-A : Houttuynia cordata Thunberg, Rubuscoreanus, Rehmannia glutinosa, Prunus yedoensis, HM-B : Houttuynia cordata Thunberg, Rubus coreanus,Rehmannia glutinosa, Angelica gigas nakai) supresses the development of atopic dermatitis in Balb/c micesensitized by ovalbumin. Methods: Mice were sensitized by intraperitoneal injection of ovalbumin plus aluminum hydroxide hydrate,followed by epicutaneous sensitization for 6 weeks. After induced atopic dermatitis, HM-A and HM-B were orallyadministrated for two weeks(once a two days) as a 50 mg/kg concentration. After all mice were sacrificed at theend of the experiment, skin and blood were harvested. Results: Oral administration group was reduced the infiltration of eosinophils, mast cells and total T cells on theskin areas as well as blood analysis. Also, cutaneous expression of IL-4,13,17 decreased. Blood IgE level wasdecreased. Conclusion: These drugs could be potential candidates for the atopic dermatitis.
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