The Effect of Urokinase Infusion Regimens on Thrombolysis-a Numerical Study
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Numerical analysis was performed on the enzyme transport and the flow fields in order to predict the effectiveness of urokinase injection regimens in clot dissolution. The species and momentum transport equations were numerically solved for the case of uniform perfusion of enzyme into a fibrin clot for an arterial thrombus and a deep vein thrombus models. In order to predict the thrombus lysis efficiency of continuous and forced intermittent injections, enzyme perfusion and clot lysis were simulated for the different injection velocities. Intermittent injection showed faster clot lysis compared to continuous perfusion, and lysis efficiency was increased as injection velocity increased.
Abstract
Numerical analysis was performed on the enzyme transport and the flow fields in order to predict the effectiveness of urokinase injection regimens in clot dissolution. The species and momentum transport equations were numerically solved for the case of uniform perfusion of enzyme into a fibrin clot for an arterial thrombus and a deep vein thrombus models. In order to predict the thrombus lysis efficiency of continuous and forced intermittent injections, enzyme perfusion and clot lysis were simulated for the different injection velocities. Intermittent injection showed faster clot lysis compared to continuous perfusion, and lysis efficiency was increased as injection velocity increased.
참고문헌 (19)
- "Thrombolysis with tissue type plasmonogen activator", 19, pp.503~508 (1994)
- "In vitro model to evaluate the relative efficacy of catheter directed thrombolytic strategies", 9, pp.121~128 (1996)
- "in vitro comparison between automatic and manual pulse spry injection", 19, pp.423~427 (1996), Local intraarterial thrombolysis
- "Ultrasound-enhanced thrombolysis", 18, pp.239~246 (2001)
- "Dependence of blood clot lysis on the mode of transport of urokinase into a clot", 65, pp.549~552 (1991), A. Blinc
- "Lysing patterns of retracted blood clots with diffusion or bulk flow transport of urokinase into the clots a magnetic resonance study in vitro", 68, pp.667~671 (1992), A. Blinc
- "Transport phenomena and clot dissolving therapy:An experimental investigation of diffusion-controlled and permeation-enhanced fibrinolysis", 72, pp.105~112 (1994)
- "Inner clot diffusion and permeation during fibrinolysis", 65, pp.2622~2643 (1993)
- "Quantitative evaluation of selective thrombolysis techniques:Influence of catheter charac-teristics and delivery parameters", 43, pp.111~119 (1998)
- "Intraarterial throm-bolysis of lower extremity occlusions randomized comparison of forced periodic infusion and conventional slow continuous infusion", 188, pp.861~867 (1993)
- "Flow through clots determines the rate and pattern of fibrnolysis", 71, pp.230~235 (1994)
- "Numerical analysis of forced injection of enzyme during thrombolysis accepted for publication"
- "Fibrin has larger pores when formed in presence of erythrocytes", 253, pp.1069~1073 (1987)
- "Engineering design of optimal strategies for blood clot dissolution", 1, pp.427~461 (1999)
- "Quantifying the effects of locally delivered anticoagulant drugs:Modification of an in vivo model of venous thrombosis", 30, pp.323~326 (1993)
- "Accelerated thrombolysis with a microporous angioplasty balloon", 18, pp.s66~ (1995)
- "Ultralipid urokinase in hemodialysis access occlusion", 2, pp.503~506 (1991)
- "Factors influencing the lysis of ex vivo human thrombi. Fibrolysis", pp.103~109 (1996)
- "Fibrin in human plasma gel:gel architectures governed by rate and nature of fibrinogen activation", 75, pp.521~538 (1994)