3.0 T MRI 환경에서 마이크로비드를 이용한 서브복셀 추적에 관한 수치해석적 연구
Numerical Study on the Sub-Voxel TrackingUsing Micro-Beads in a 3.0 T MRI
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Abstract
In molecular imaging studies via magnetic resonance imaging, in vivo cell tracking is an important issue for the observation of cell therapy or disease behavior. High resolution imaging and longitudinal study are necessary to track the cell movement. Since the field inhomogeneity extends over several voxels, we have performed the numerical analysis using the sub-voxel method dividing a voxel of MR image into several elements and the information about the field inhomogeneity distribution around the micro-beads. We imbedded ferrite-composite micro-beads with the size of 20-150 μm in the subject substituted for cells to induce local field distortion. In the phantom imaging with the isotropic voxel size of 200 μm3, we could confirm the feasibility of sub-voxel tracking in a 3.0 T MRI.
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