저자장 자기공명영상 시스템 내에서 초상자성나노입자 온열치료를 위한 발열 평가
Feasibility Study on Magnetic Nanoparticle Hyperthermia in Low Field MRI
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For the combination of MRI and magnetic particle hyperthermia(MPH), we investigated the relative heatingefficiency with respect to the strength of the static magnetic field under which the magnetic nanoparticles areto be heated by RF magnetic field. We performed nanoparticle heating experiments at the fringe field of 3T MRImagnet with applying the RF magnetic field perpendicularly to the static magnetic field. The static field strengthswere 0T, 0.1T, 0.2T, and 0.3T. To prevent the coil heat from conducting to the nanoparticle suspension, we cooledthe heating solenoid coil with temperature-controlled water with applying heat insulators between the solenoid coiland the nanoparticle container. We observed significant decrease of heat generation, up to 6% at 0.3T(100% at 0T),due to the magnetic saturation of the nanoparticles of 15 nm diameter under the static field. We think MPH is stillfeasible at low magnetic field lower than 0.3T if stronger RF magnetic field generation is permitted.
Abstract
For the combination of MRI and magnetic particle hyperthermia(MPH), we investigated the relative heatingefficiency with respect to the strength of the static magnetic field under which the magnetic nanoparticles areto be heated by RF magnetic field. We performed nanoparticle heating experiments at the fringe field of 3T MRImagnet with applying the RF magnetic field perpendicularly to the static magnetic field. The static field strengthswere 0T, 0.1T, 0.2T, and 0.3T. To prevent the coil heat from conducting to the nanoparticle suspension, we cooledthe heating solenoid coil with temperature-controlled water with applying heat insulators between the solenoid coiland the nanoparticle container. We observed significant decrease of heat generation, up to 6% at 0.3T(100% at 0T),due to the magnetic saturation of the nanoparticles of 15 nm diameter under the static field. We think MPH is stillfeasible at low magnetic field lower than 0.3T if stronger RF magnetic field generation is permitted.
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