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반복적 양측 운동학습에 따른 대뇌 및 소뇌 피질 활성화

Activations of Cerebral and Cerebellar Cortex Induced by Repetitive Bilateral Motor Exercise

송성재|김영호|태기식
대한의용생체공학회 (The Korea Society Of Medical & Biological Engineering)|2007.02|의공학회지 (Journal of biomedical Engineering Research)|제28권 제1호|pp. 139-147

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Abstract

The aim of this study was to evaluate effects of short-term repetitive-bilateral excercise on the activation of motor network using functional magnetic resonance imaging (fMRI). The training program was performed at 1 hr/day, 5 days/week during 6 weeks. Fugl-Meyer Assessments (FMA) were performed every two weeks during the training. We compared cerebral and cerebellar cortical activations in two different tasks before and after the training program: (1) the only unaffected hand movement (Task 1); and (2) passive movements of affected hand by the active movement of unaffected hand (Task 2). fMRI was performed at 3T with wrist flexion-extension movement at 1 during the motor tasks. All patients showed significant improvements of FMA scores in their paretic limbs after training. fMRI studies in Task 1 showed that cortical activations decreased in ipsilateral sensorimotor cortex but increased in contralateral sensorimotor cortex and ipsilateral cerebellum. Task 2 showed cortical reorganizations in bilateral sensorimotor cortex, premotor area, supplemetary motor area and cerebellum. Therefore, this study demonstrated that plastic changes of motor network occurred as a neural basis of the improvement subsequent to repetitive-bilateral excercise using the symmetrical upper-limb arm motion trainer.

참고문헌 (43)

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