인체 내부 환경 변화 모사에 따른 삼투압 기반 약물주입펌프의 기능 평가 연구
Studies on Osmotically Driven Drug Infusion Pump Under the Change in Body-Simulating Environment
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Various types of implantable drug delivery devices have attracted significant attention for several decades to improve drug bioavailability and reduce side effects, thus enhancing therapeutic efficacy and patients’ compliance. However, when implanted into the body, the devices may be influenced by the changes in physiological condition, such as temperature, pH or ionic concentration. Thus, the drug release rates could be also altered concurrently. Therefore, in this work, we employed an implantable ALZET® Osmotic Pump, which has been widely used to locally deliver various therapeutic agents and examined the effect of pH, temperature and ionic concentration on its drug release rate. For this, we performed in vitro cell tests to simulate the condition of local tissues influenced by the altered drug release rates, where we used diclofenac sodium as a model drug
Abstract
Various types of implantable drug delivery devices have attracted significant attention for several decades to improve drug bioavailability and reduce side effects, thus enhancing therapeutic efficacy and patients’ compliance. However, when implanted into the body, the devices may be influenced by the changes in physiological condition, such as temperature, pH or ionic concentration. Thus, the drug release rates could be also altered concurrently. Therefore, in this work, we employed an implantable ALZET® Osmotic Pump, which has been widely used to locally deliver various therapeutic agents and examined the effect of pH, temperature and ionic concentration on its drug release rate. For this, we performed in vitro cell tests to simulate the condition of local tissues influenced by the altered drug release rates, where we used diclofenac sodium as a model drug
참고문헌 (15)
- L. Allen, "Ansel’s pharmaceutical dosage forms and drug delivery systems", pp.832~ (2013), Lippincott Williams & Wilkins
- K. E. Uhrich, "Polymeric systems for controlled drug release", Chem Rev, 99(11), pp.3181~3198 (1999)
- T. M. Allen, "Drug delivery systems: entering the mainstream", Science, 303(5665), pp.1818~1822 (2004)
- A. C. Richards Grayson, "Multi-pulse drug delivery from a resorbable polymeric microchip device", Nat Mater, 2(11), pp.767~772 (2003)
- D. V. McAllister, "Microfabricated microneedles for gene and drug delivery", Annu Rev Biomed Eng, 2, pp.289~313 (2000)
- S. S. Davis, "Polymeric Microspheres as Drug Carriers", Biomaterials, 9(1), pp.111~115 (1988)
- A. Kumari, "Biodegradable polymeric nanoparticles based drug delivery systems", Colloids Surf, B, 75(1), pp.1~18 (2010)
- S. D. Allison, "Analysis of initial burst in PLGA microparticles", Expert Opin Drug Delivery, 5(6), pp.615~628 (2008)
- 여윤, "Control of Encapsulation Efficiency and Initial Burst in Polymeric Microparticle Systems", Archives of Pharmacal Research, 27(1), pp.1~10 (2004), 대한약학회
- R. K. Verma, "Osmotic pumps in drug delivery", Crit Rev Ther Drug Carrier Syst, 21(6), pp.477~520 (2004)
- P. Cuevas, "Basic fibroblast growth factor(FGF)promotes cartilage repair in vivo", Biochem Biophys Res Commun, 156(2), pp.611~618 (1988)
- L. Diaz-Rodriguez, "Effects of indomethacin, nimesulide, and diclofenac on human MG-63osteosarcoma cell line", Biol Res Nurs, 14(1), pp.98~107 (2012)
- A. Lardner, "The effects of extracellular pH on immune function", J Leukoc Biol, 69(4), pp.522~530 (2001)
- 이윤우, "초임계 PGSS 법을 이용한 Poly(lactide-co-glycolide)와단백질의 마이크로복합체 제조에 관한 연구", 청정기술, 12(2), pp.53~61 (2006), 한국청정기술학회
- G. Healing, "Handbook of pre-clinical continuous intravenous infusion", pp.265~281 (2000), Taylor & Francis