기억장애성 경도인지장애 환자의 양전자방출단층촬영검사에서 아밀로이드 침착이 해마 대사량에 미치는 영향 : 예비연구
Effect of Amyloid Deposition in PET on Hippocampal Metabolism in Amnestic-Mild Cognitive Impairment : Pilot Study
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초록
Objectives：Most studies of hippocampal metabolism(HM) in amnestic mild cognitive impairment(aMCI) gave inconsistent results. Our objective was to evaluate the effect of amyloid-beta(Aβ) status on hippocampal metabolism in aMCI. Methods：Overall, 23 aMCI underwent three-dimensional magnetic resonance imaging(MRI), 18F-fluorodeoxyglucose-positron emission tomography(18FDG-PET) and 18F-Fluorbetaben amyloid positron emission tomography (amyloid-PET). According to Aβ status on amyloid PET, 23 aMCI were classified as either Aβ+aMCI(N=13) or Aβ-aMCI(N= 10). The primary outcome was HM using 18FDG-PET and we investigate the difference on HM between Aβ+aMCI and Aβ-aMCI using analysis of variance(ANOVA) model, after controlling hippocampal volume. Results：We found that HM was more decreased in Aβ+aMCI than Aβ-aMCI. This result was not changed after controlling hippocampal volume. Conclusion：Our findings suggest that Aβ+ is associated with decreased HM, regardless of hippocampal volume, in aMCI.
Abstract
Objectives：Most studies of hippocampal metabolism(HM) in amnestic mild cognitive impairment(aMCI) gave inconsistent results. Our objective was to evaluate the effect of amyloid-beta(Aβ) status on hippocampal metabolism in aMCI. Methods：Overall, 23 aMCI underwent three-dimensional magnetic resonance imaging(MRI), 18F-fluorodeoxyglucose-positron emission tomography(18FDG-PET) and 18F-Fluorbetaben amyloid positron emission tomography (amyloid-PET). According to Aβ status on amyloid PET, 23 aMCI were classified as either Aβ+aMCI(N=13) or Aβ-aMCI(N= 10). The primary outcome was HM using 18FDG-PET and we investigate the difference on HM between Aβ+aMCI and Aβ-aMCI using analysis of variance(ANOVA) model, after controlling hippocampal volume. Results：We found that HM was more decreased in Aβ+aMCI than Aβ-aMCI. This result was not changed after controlling hippocampal volume. Conclusion：Our findings suggest that Aβ+ is associated with decreased HM, regardless of hippocampal volume, in aMCI.
참고문헌 (26)
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