Three-Dimensional Magnetic Particle Imaging Utilizing an Open-type System: A Feasibility Study
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Localization of magnetic nanoparticles is critical for precise intravascular therapy and drug delivery. Conventional magneticparticle imaging scanners are closed bore-type structures in which the working space is limited to the inside of the coil, leadingto poor compatibility with other medical devices and limited user accessibility during operation. This paper presents an opentypemagnetic particle imaging (OMPI) scanner that can monitor magnetic particles in three-dimensional space. The deviceintegrates an asymmetric arrangement of soft-core electromagnetic coils and a single side for magnetic spectroscopy. Themonitoring capabilities of the device were designed based on magnetic particle imaging technology. It is suitable for applicationwith a concentration of magnetic particles of around 55.8 mg/mL within a region of interest of 30 × 30 × 30mm3 . The imagingfeasibility of this system was verified by in vitro experiments. The proposed system enables magnetic particle imaging to beapplied more flexibly to complex medical scenarios.
Abstract
Localization of magnetic nanoparticles is critical for precise intravascular therapy and drug delivery. Conventional magneticparticle imaging scanners are closed bore-type structures in which the working space is limited to the inside of the coil, leadingto poor compatibility with other medical devices and limited user accessibility during operation. This paper presents an opentypemagnetic particle imaging (OMPI) scanner that can monitor magnetic particles in three-dimensional space. The deviceintegrates an asymmetric arrangement of soft-core electromagnetic coils and a single side for magnetic spectroscopy. Themonitoring capabilities of the device were designed based on magnetic particle imaging technology. It is suitable for applicationwith a concentration of magnetic particles of around 55.8 mg/mL within a region of interest of 30 × 30 × 30mm3 . The imagingfeasibility of this system was verified by in vitro experiments. The proposed system enables magnetic particle imaging to beapplied more flexibly to complex medical scenarios.